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Akademický článek

Recovery of a degraded area using Platycyamus regnellii (Fabaceae) saplings

Autor: L. F. Bispo, G. L. Demolin-Leite, W. M. Fagundes, A. M. S. A. Abreu, J. M. M. dos Santos, F. M. M. Oliveira, V. J. Silva, T. O. Souza, Y. O. R. Silva, F. L. Amaral

Publikováno v: Brazilian Journal of Biology, Vol 83 (2023)

Externí odkaz: https://doaj.org/article/9432b5025daf429cbb6baf4d654d52e0

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Akademický článek

Novel Organic Salts Based on Mefloquine: Synthesis, Solubility, Permeability, and In Vitro Activity against Mycobacterium tuberculosis

Autor: Dário Silva, Márcio V. C. Lopes, Željko Petrovski, Miguel M. Santos, Jussevania P. Santos, Sueli F. Yamada-Ogatta, Marcelle L. F. Bispo, Marcus V. N. de Souza, Ana Rita C. Duarte, Maria C. S. Lourenço, Raoni Schroeder B. Gonçalves, Luis C. Branco

Publikováno v: Molecules, Vol 27, Iss 16, p 5167 (2022)

The development of novel pharmaceutical tools to efficiently tackle tuberculosis is the order of the day due to the rapid development of resistant strains of Mycobacterium tuberculosis. Herein, we report novel potential formulations of a repurposed d

Externí odkaz: https://doaj.org/article/a6a4378ca57e49f6ae1230e45fe18e10

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In-vitro biological evaluation of 3,3′,5,5′-tetramethoxy-biphenyl-4,4′-diol and molecular docking studies on trypanothione reductase and Gp63 from Leishmania amazonensis demonstrated anti-leishmania potential

Autor: Jéseka G. Schirmann, Bruna T. S. Bortoleti, Manoela D. Gonçalves, Fernanda Tomiotto-Pellissier, Priscila G. Camargo, Milena M. Miranda-Sapla, Camilo H. S. Lima, Marcelle L. F. Bispo, Idessania N. Costa, Ivete Conchon-Costa, Wander R. Pavanelli, Robert F. H. Dekker, Aneli M. Barbosa-Dekker

Publikováno v: Scientific Reports. 13

Available treatments for leishmaniasis have been widely used since the 1940s but come at a high cost, variable efficacy, high toxicity, and adverse side-effects. 3,3′,5,5′-Tetramethoxy-biphenyl-4,4′-diol (TMBP) was synthesized through laccase-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86415c34e0b612e0326d75a530158e2e
https://doi.org/10.1038/s41598-023-34124-9

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Carvacrol and its Semi-synthetic Derivatives as Potential Antibacterial Agents

Autor: Isabelle H. Castro, Fabrício A. A. Oliveira, Carla C. Perez, Marcelle L. F. Bispo

Publikováno v: Revista Virtual de Química.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a395b4fc18433a8d16b77d6768f0c4b
https://doi.org/10.21577/1984-6835.20230020

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In Vitro Antimicrobial Screening of Benzoylthioureas: Synthesis, Antibacterial Activity toward Streptococcus agalactiae and Molecular Docking Study

Autor: Renata P. Biasi‐Garbin, Marciéli Fabris, Ana Elisa B. Morguette, Gabriella M. Andriani, Weslei R. C. Cabral, Patrícia M. L. Pereira, Tiago O. Brito, Fernando Macedo, Camilo H. Da Silva Lima, César A. C. Lancheros, Celso V. Nakamura, Phileno Pinge‐Filho, Eliandro R. Tavares, Lucy M. Yamauchi, Marcelle L. F. Bispo, Sueli F. Yamada‐Ogatta

Publikováno v: ChemistrySelect. 7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3efedc390156ccab2d7d49eaae6cc293
https://doi.org/10.1002/slct.202202117

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Akademický článek

Anti-Mycobacterial Evaluation of 7-Chloro-4-Aminoquinolines and Hologram Quantitative Structure–Activity Relationship (HQSAR) Modeling of Amino–Imino Tautomers

Autor: Marcelle L. F. Bispo, Camilo H. S. Lima, Laura N. F. Cardoso, André L. P. Candéa, Flávio A. F. M. Bezerra, Maria C. S. Lourenço, Maria G. M. O. Henriques, Ricardo B. Alencastro, Carlos R. Kaiser, Marcus V. N. Souza, Magaly G. Albuquerque

Publikováno v: Pharmaceuticals, Vol 10, Iss 2, p 52 (2017)

In an ongoing research program for the development of new anti-tuberculosis drugs, we synthesized three series (A, B, and C) of 7-chloro-4-aminoquinolines, which were evaluated in vitro against Mycobacterium tuberculosis (MTB). Now, we report the ant

Externí odkaz: https://doaj.org/article/1bd0b3f01c1141e3a7d926e13ac67d2d

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A Importância do Núcleo Quinolínico e seus Derivados no Desenvolvimento de Fármacos

Autor: A. C. Pinheiro, M. L. F. Bispo, M. V. N. Souza

Publikováno v: Revista Fitos. 5:53-63

No campo da descoberta de fármacos, o núcleo quinolínico é uma importante classe de compostos heterocíclicos, visto que está presente em muitos produtos naturais e sintéticos, os quais possuem um amplo espectro de atividades biológicas. Porta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2cf430078038eb15af3caf09d525f72c
https://doi.org/10.32712/2446-4775.2010.119

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Anti-tuberculosis evaluation and conformational study of N-acylhydrazones containing the thiophene nucleus

Autor: Laura N F, Cardoso, Marcelle L F, Bispo, Carlos R, Kaiser, James L, Wardell, Solange M S V, Wardell, Maria C S, Lourenço, Flávio A F M, Bezerra, Rodrigo P P, Soares, Marcele N, Rocha, Marcus V N, de Souza

Publikováno v: Archiv der Pharmazie. 347(6)

A series of N-acylhydrazonyl-thienyl derivatives (compounds 2 and 3), mainly of the type 2-(aryl-CH=N-NHCOCH2 )-thiene (2: aryl = substituted-phenyl; 3: aryl = heteroaryl) were evaluated against Mycobacterium tuberculosis. Particularly active compoun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::959c9ef32e779220098054e791e7483d
https://pubmed.ncbi.nlm.nih.gov/24616002

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Akademický článek

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