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Akademický článek

Inhibition of antiapoptotic BCL-2 proteins with ABT-263 induces fibroblast apoptosis, reversing persistent pulmonary fibrosis

Autor: Joseph C. Cooley, Nomin Javkhlan, Jasmine A. Wilson, Daniel G. Foster, Benjamin L. Edelman, Luis A. Ortiz, David A. Schwartz, David W.H. Riches, Elizabeth F. Redente

Publikováno v: JCI Insight, Vol 8, Iss 3 (2023)

Patients with progressive fibrosing interstitial lung diseases (PF-ILDs) carry a poor prognosis and have limited therapeutic options. A hallmark feature is fibroblast resistance to apoptosis, leading to their persistence, accumulation, and excessive

Externí odkaz: https://doaj.org/article/96e206f68f934c4eb1c69abb77fc06c1

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Akademický článek

449 Progression of silica-induced pulmonary fibrosis is arrested after selective ablation of Col1a1+ fibroblasts

Autor: Daniel G Foster, Nomin Javkhlan, Jasmine Wilson, Benjamin L. Edelman, David W. H. Riches, Elizabeth F. Redente

Publikováno v: Journal of Clinical and Translational Science, Vol 7, Pp 133-134 (2023)

OBJECTIVES/GOALS: Silicosis is a highly fatal progressive fibrotic disease of the lungs characterized by accumulation and persistence of fibroblasts that excessively deposit Collagen1a1. We sought to eliminate Collagen1a1-expressing fibroblasts throu

Externí odkaz: https://doaj.org/article/5fc1681d4c9945b19ea82670e716be67

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Akademický článek

Loss of Fas signaling in fibroblasts impairs homeostatic fibrosis resolution and promotes persistent pulmonary fibrosis

Autor: Elizabeth F. Redente, Sangeeta Chakraborty, Satria Sajuthi, Bart P. Black, Ben L. Edelman, Max A. Seibold, David W.H. Riches

Publikováno v: JCI Insight, Vol 6, Iss 1 (2021)

Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible fibrotic disease of the distal lung alveoli that culminates in respiratory failure and reduced lifespan. Unlike normal lung repair in response to injury, IPF is associated with the ac

Externí odkaz: https://doaj.org/article/8c0212f0ed444e41b6c75c79e4418af3

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Akademický článek

[18F]FDG, [11C]PiB, and [18F]AV-1451 PET Imaging of Neurodegeneration in Two Subjects With a History of Repetitive Trauma and Cognitive Decline

Autor: David O. Okonkwo, Ross C. Puffer, Davneet S. Minhas, Sue R. Beers, Kathryn L. Edelman, Jane Sharpless, Charles M. Laymon, Brian J. Lopresti, Steven Benso, Ava M. Puccio, Sudhir Pathak, Milos D. Ikonomovic, Joseph M. Mettenburg, Walter Schneider, Chester A. Mathis, James M. Mountz

Publikováno v: Frontiers in Neurology, Vol 10 (2019)

Background: Trauma-related neurodegeneration can be difficult to differentiate from multifactorial neurodegenerative syndromes, both clinically and radiographically. We have initiated a protocol for in vivo imaging of patients with suspected TBI-rela

Externí odkaz: https://doaj.org/article/3480f8d71f454129a8f9bd8538521328

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Akademický článek

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Akademický článek

Myeloid sarcoma of the periprostatic tissue and prostate: Case report and review of literature

Autor: Shalini Koppisetty, Brain L Edelman, Atul Rajpurkar

Publikováno v: Urology Annals, Vol 8, Iss 3, Pp 348-354 (2016)

Myeloid sarcoma (MS) is a rare extramedullary tumor composed of immature cells of myeloid lineage that destroy the original tissue architecture in which it is found. It is most commonly identified in patients with acute myelogenous leukemia, and less

Externí odkaz: https://doaj.org/article/20206b999ac44c3e92fbfbf403cb7f99

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Akademický článek

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Akademický článek

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Mental Well-Being and Sexual Intimacy among Men and Gender Diverse People Who Have Sex with Men during the First UK COVID-19 Lockdown: A Mixed-Methods Study

Autor: Natalie L. Edelman, T. Charles Witzel, Phil Samba, Will Nutland, Tom Nadarzynski

Publikováno v: International Journal of Environmental Research and Public Health; Volume 19; Issue 12; Pages: 6985

This mixed-methods study aimed to explore mental well-being, circumstances and strategies around managing sexual intimacy and risk during the first UK COVID-19 lockdown (Spring 2020) among men and gender diverse people who have sex with men (MGDPSM),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b659fc20334094557f47780ed809533d
https://pubmed.ncbi.nlm.nih.gov/35742234

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