Zobrazeno 1 - 10
of 33
pro vyhledávání: '"L. E. Rinkema"'
Autor:
David K. Herron, Bollinger Ng, Baldwin Rf, Jason Scott Sawyer, Carlos R. Roman, Richard Waltz Harper, L E Rinkema, Jerome H. Fleisch
Publikováno v:
Journal of Medicinal Chemistry. 35:1191-1200
A hypothetical model for receptor binding of leukotriene D4 (LTD4) was deduced from conformational analysis of LTD4 and from the structure-activity relationships (SAR) of known LTD4 receptor antagonists. A new structural series of LTD4 receptor antag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2faf4ca01a4db7df10dcbd6ff2b70b58
https://doi.org/10.1021/jm00085a004
https://doi.org/10.1021/jm00085a004
Autor:
David P. Henry, Weihua L. Russell, Stephen M. Spaethe, Carlos R. Roman, Kerry G. Bemis, Jerome H. Fleisch, L E Rinkema, Winston Stanley Marshall
Publikováno v:
Journal of Pharmacy and Pharmacology. 42:620-625
LY171883, (1-[2-hydroxy-3-propyl-4-((4(1H-tetrazol-5-yl)butoxy)phenyl]ethanone), a leukotriene (LT) D4/E4 receptor antagonist, was assessed in comparison with two well known phosphodiesterase inhibitors, isobutylmethyl-xanthine (IBMX) and theophyllin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b388635fe39b95366f3797f98abce7
https://doi.org/10.1111/j.2042-7158.1990.tb06619.x
https://doi.org/10.1111/j.2042-7158.1990.tb06619.x
Publikováno v:
Journal of veterinary pharmacology and therapeutics. 19(3)
Tilmicosin(TM), a macrolide antibiotic and active ingredient in formulated Micotil 300 (Eli Lilly and Co., Indianapolis, IN, USA), is the active ingredient in a formulated animal product used for the treatment of respiratory tract infections in cattl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e099e25ceb0767b68396f519f88e4e2
https://pubmed.ncbi.nlm.nih.gov/8803881
https://pubmed.ncbi.nlm.nih.gov/8803881
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 348
Guinea pig inferior vena cava contracted in response to leukotriene (LT)C4, LTD4, LTE4 U46619, phenylephrine, histamine, and KCl. Although LTC4, LTD4, and U46619 were the most potent agonists, active tension generated by these eicosanoids was only ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6d1378d00dbd0fb427797333624702
https://doi.org/10.1007/bf00173213
https://doi.org/10.1007/bf00173213
Autor:
G P, Dubé, D E, Mais, J A, Jakubowski, K A, Brune, B G, Utterback, T A, True, L E, Rinkema, W L, Kurtz
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 262(2)
The stereoisomers of S-145, a novel thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor ligand, were compared to TXA2/PGH2 receptor antagonists, SQ29548 and BM13505 in guinea pig platelets, aortas and trachea. Equilibrium binding assays in platelets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c25aca2ddc6af31778defc60720948d
https://pubmed.ncbi.nlm.nih.gov/1386888
https://pubmed.ncbi.nlm.nih.gov/1386888
Publikováno v:
Journal of medicinal chemistry. 35(7)
This report describes the development of a series of highly potent quinoline-based leukotriene D4 (LTD4) receptor antagonists containing an N-benzyl-substituted phenyltetrazole moiety. They were designed to provide both the correct positioning of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b84996c66f03b2c9e9e64576f82eb3e
https://pubmed.ncbi.nlm.nih.gov/1313877
https://pubmed.ncbi.nlm.nih.gov/1313877
Autor:
R A, Hahn, B R, MacDonald, E, Morgan, B D, Potts, C J, Parli, L E, Rinkema, C A, Whitesitt, W S, Marshall
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 260(3)
In vitro studies have shown LY203647 to be a selective antagonist of contractile responses to leukotriene (LT) D4 and LTE4 in guinea pig ileum, trachea and lung parenchyma. In pithed rat, i.v. injection of LTD4 produced pressor responses that were se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::45cffe9c0184d6ecc8bbb6f352affe2a
https://pubmed.ncbi.nlm.nih.gov/1312172
https://pubmed.ncbi.nlm.nih.gov/1312172
Autor:
L E Rinkema, Jerome H. Fleisch, R. A. Hahn, Carlos R. Roman, Robert D. Dillard, McCullough D, Francis Patrick Carr
Publikováno v:
Journal of medicinal chemistry. 34(9)
Two series of (phenylmethoxy)phenyl compounds derived from the structure of LY163443 were synthesized and evaluated as leukotriene D4 receptor antagonists. In the omega-[(phenylmethoxy)phenyl]-omega-oxoalkanoic acid series, 5-[4-[(4-acetyl-2-ethyl-3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4976a4b55b155eb81d60cc4d773da491
https://pubmed.ncbi.nlm.nih.gov/1654427
https://pubmed.ncbi.nlm.nih.gov/1654427
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 244:H607-H613
Total denervation of the canine heart consisted of intrapericardial neural dissection of the left atrium, left superior pulmonary vein, and main pulmonary artery and cutting of the ventrolateral cardiac nerve (stage I). The fat pad and all nerves wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e1b90cad57146354d4482e2837daa4
https://doi.org/10.1152/ajpheart.1983.244.4.h607
https://doi.org/10.1152/ajpheart.1983.244.4.h607
Publikováno v:
Biochemical Pharmacology. 33:3919-3922
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b36894f9ac46e2de6dec978d8344ff0f
https://doi.org/10.1016/0006-2952(84)90001-7
https://doi.org/10.1016/0006-2952(84)90001-7