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Autor:
V. M.G. DeBenedetti, S. C. Chia, Judith A. Welsh, William P. Bennett, N. V. Bergasa, H. Cawley, Ylermi Soini, John D. Groopman, L. E. Munoz Espinosa, A. M. DiBisceglie, C. Hansen, E. A. Jones, Catherine Sandoval, I. E. Calderon, Curtis C. Harris, Jia-Sheng Wang, G. E. Trivers
Publikováno v:
Carcinogenesis. 17(5)
The p53 tumor suppressor gene is commonly mutated in human hepatocellular carcinoma (HCC). The most frequent mutation in HCC in populations exposed to a high dietary intake of aflatoxin B1 (AFB1) is an AGGarg-->AGTser missense mutation in codon 249 o