Výsledky vyhledávání

Nicotinic receptors, smoking and schizophrenia

Autor: S, Leonard, J, Gault, C, Adams, C R, Breese, Y, Rollins, L E, Adler, A, Olincy, R, Freedman

Publikováno v: Restorative neurology and neuroscience. 12(2-3)

Neuronal nicotinic acetylcholine receptor expression was examined in schizophrenia. The incidence of smoking in schizophrenia is remarkably high and nicotine has been found to normalize an auditory evoked potential deficit seen in most subjects who s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0b87205ebac42e445c4851dbef13f65
https://pubmed.ncbi.nlm.nih.gov/12671315

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Inhibitory neurophysiological deficit as a phenotype for genetic investigation of schizophrenia

Autor: R, Freedman, C E, Adams, L E, Adler, P C, Bickford, J, Gault, J G, Harris, H T, Nagamoto, A, Olincy, R G, Ross, K E, Stevens, M, Waldo, S, Leonard

Publikováno v: American journal of medical genetics. 97(1)

Many investigators have proposed that biological endophenotypes might facilitate the genetic analysis of schizophrenia. A deficit in the inhibition of the P50 evoked response to repeated auditory stimuli has been characterized as a neurobiological de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a0be2a2f18437df9a8033d33a37235d
https://pubmed.ncbi.nlm.nih.gov/10813805

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Evidence for bilineal inheritance of physiological indicators of risk in childhood-onset schizophrenia

Autor: R G, Ross, A, Olincy, J G, Harris, A, Radant, M, Hawkins, L E, Adler, R, Freedman

Publikováno v: American journal of medical genetics. 88(2)

Childhood-onset schizophrenia is proposed to be associated with increased genetic loading compared with adult-onset schizophrenia because of its earlier age of onset and generally greater severity of symptoms. Diminished suppression of P50 auditory e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6f486aae6031f101dec8f2a746ec9665
https://pubmed.ncbi.nlm.nih.gov/10206241

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Selection of digital filtering parameters and P50 amplitude

Autor: R, Freedman, L E, Adler, H T, Nagamoto, M C, Waldo

Publikováno v: Biological psychiatry. 43(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0fe5475075ee1ba0c4fc6bd58122aa2
https://pubmed.ncbi.nlm.nih.gov/9627749

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Nicotinic Receptors and the Pathophysiology of Schizophrenia

Autor: S. Leonard, Paula C. Bickford, G. Rose, H. Nagamoto, Marina Myles-Worsley, William Byerley, Robert Freedman, Merilyne Waldo, L. E. Adler, C. Miller, V. Luntz-Leybman, Hilary Coon, K. Stevens

Publikováno v: Effects of Nicotine on Biological Systems II ISBN: 9783034874472

Nicotine normalizes several physiological abnormalities found in schizophrenia, including a deficit in the inhibitory gating of the P50 evoked response to repeated auditory stimuli. Animal models suggest the involvement of α7 nicotinic receptor subu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e14459c8ba1d3b1d86239ec01441bf22
https://doi.org/10.1007/978-3-0348-7445-8_40

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Receptor regulation

Publikováno v: Experientia Supplementum ISBN: 9783764350871

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a777a6b53d8e7ae8b73c8481eee7afa0
https://doi.org/10.1007/978-3-0348-7416-8_12

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Concurrent medical illness in the schizophrenic patient. Epidemiology, diagnosis, and management

Autor: L E, Adler, J M, Griffith

Publikováno v: Schizophrenia research. 4(2)

The management of the medically ill schizophrenic patient presents a dual dilemma for the physician. The patient may have a serious medical illness that must be diagnosed and effectively treated, yet the patient's psychiatric disorder may interfere w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c731fe18717463fc2d3697d10772959f
https://pubmed.ncbi.nlm.nih.gov/1674884

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Gating of auditory response in schizophrenics and normal controls. Effects of recording site and stimulation interval on the P50 wave

Autor: H T, Nagamoto, L E, Adler, M C, Waldo, J, Griffith, R, Freedman

Publikováno v: Schizophrenia research. 4(1)

Auditory evoked potentials were recorded using a paired stimulus, conditioning-testing paradigm from 14 schizophrenic patients and 13 normal subjects with no family history of psychotic disorder. Previous studies of the vertex P50 wave using this par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e6d5d1886e463d9039043bed9ef6d7bc
https://pubmed.ncbi.nlm.nih.gov/1848997

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