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Lack of effect of pantoprazole on the pharmacodynamics and pharmacokinetics of warfarin [see comments]

Autor: G. Groenewoud, H. Bliesath, Robert Schall, F. O. Müller, V. W. Steinijans, H. K. L. Hundt, L. Duursema, M. V. Middle

Publikováno v: British Journal of Clinical Pharmacology. 39:700-703

Twenty-six healthy males took part in this double-blind, randomised, placebo-controlled, two-period, cross-over study. Pantoprazole (40 mg) (test) or placebo (reference) were administered once daily, for 8 days, with a 3 week washout period. A single

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c54f17c3fa1840ef7fcd9f79d0b96b69
https://doi.org/10.1111/j.1365-2125.1995.tb05732.x

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Model to Detect Warfarin-Drug Interactions in Man

Autor: F. O. Müller, B. H. Meyer, A. du P. Heyns, H. G. Luus, L. Duursema, H. K. L. Hundt

Publikováno v: Drug Investigation. 4:395-402

The aim of this study was to develop and validate a safe and sensitive in vivo model for the detection of potential warfarin-drug interactions in man. A single 25mg dose of racemic warfarin was administered to 18 consenting healthy male volunteers on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24305122f0840d3411e394e9160dde69
https://doi.org/10.1007/bf03258417

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Bioavailability of two selegiline hydrochloride tablet products

Autor: F O, Müller, R, Schall, H K, Hundt, A, Joubert, M V, Middle, A R, Muir, L, Duursema, G, Groenewoud, K J, Swart

Publikováno v: Arzneimittel-Forschung. 46(11)

The bioavailability of two selegiline HCl (CAS 14611-52-0) tablet products was compared in a single-blind, single-dose, randomised, two-way, cross-over study with 25 healthy volunteers. A test preparation of selegiline HCl (4 x 5 mg tablets) was comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7224aa545be4a4d5fd212b76eddd4d8d
https://pubmed.ncbi.nlm.nih.gov/8955861

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Study of the effect of miglitol on the pharmacokinetics and pharmacodynamics of warfarin in healthy males

Autor: R, Schall, F O, Müller, H K, Hundt, L, Duursema, G, Groenewoud, M V, Middle

Publikováno v: Arzneimittel-Forschung. 46(1)

This was a double-blind, randomised, placebo-controlled, cross-over study to determine the possible pharmacodynamic and pharmacokinetic interaction of miglitol (CAS 72432-03-2, Bay m 1099) and warfarin sodium (CAS 129-06-6) in healthy volunteers. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::675c804baa5e3d28727c11dac87af13a
https://pubmed.ncbi.nlm.nih.gov/8821516

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Relative bioavailability of rifampicin, isoniazid and ethambutol from a combination tablet vs. concomitant administration of a capsule containing rifampicin and a tablet containing isoniazid and ethambutol

Autor: R, Schall, F O, Müller, L, Duursema, G, Groenewoud, H K, Hundt, M V, Middle, E M, Mogilnicka, K J, Swart

Publikováno v: Arzneimittel-Forschung. 45(11)

Twenty male volunteers who were slow metabolisers of isoniazid, completed this single-blind, single-dose, randomised, cross-over study to compare the bioavailability of rifampicin (CAS 13292-46-1), isoniazid (CAS 54-85-3) and ethambutol (CAS 1070-11-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d6d6a15c577f60ac3db7ce185a64b0c
https://pubmed.ncbi.nlm.nih.gov/8929247

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Lack of effect of pantoprazole on the pharmacodynamics and pharmacokinetics of warfarin

Autor: L, Duursema, F O, Müller, R, Schall, M V, Middle, H K, Hundt, G, Groenewoud, V W, Steinijans, H, Bliesath

Publikováno v: British journal of clinical pharmacology. 39(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::351b9f13f73165bad2a25e003ef5cf56
https://pubmed.ncbi.nlm.nih.gov/7654493

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Relative bioavailability of four controlled-release nifedipine products

Autor: F. O. Müller, A. M. C. van Schalkwyk, H. K. L. Hundt, L. Duursema, Robert Schall, M.S. van Dyk, G. Groenewoud

Publikováno v: Biopharmaceuticsdrug disposition. 15(6)

Four controlled-release nifedipine products were investigated in two clinical studies. In study 1, 22 healthy male volunteers took part in an open, multiple-dose, randomized, crossover study to determine the relative bioavailability of two 10 mg cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22b1669745441e33476ec4e9d3b9e1b
https://pubmed.ncbi.nlm.nih.gov/7993987

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