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The Sodium–Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model

Autor: Benoît Jagu, Jocelyne Magré, L. Dollet, Bertrand Cariou, Xavier Prieur, Xavier Marechal, David Montaigne, Michael Joubert, Cédric Le May, Audrey Ayer, Gilles Toumaniantz, Flavien Charpentier, Angela Tesse, Alain Manrique, Bart Staels

Publikováno v: Diabetes
Diabetes, American Diabetes Association, 2017, 66 (4), pp.1030-1040. ⟨10.2337/db16-0733⟩
Diabetes, 2017, Equipe IIa Equipe III Equipe IV, 66 (4), pp.1030--1040. ⟨10.2337/db16-0733⟩

International audience; Type 2 diabetes mellitus (T2DM) is a well-recognized independent risk factor for heart failure. T2DM is associated with altered cardiac energy metabolism, leading to ectopic lipid accumulation and glucose overload, the exact c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3b3d9448d4ca9711f0c8887a03e244
https://hal.archives-ouvertes.fr/hal-03013302

Seipin deficiency alters brown adipose tissue thermogenesis and insulin sensitivity in a non-cell autonomous mode

Autor: C. Le May, Claire Pecqueur, L. Dollet, M. Joubert, Jocelyne Magré, Bertrand Cariou, Audrey Ayer, L. Arnaud, V. Blouin, Xavier Prieur

Publikováno v: Scientific Reports
Scientific Reports, 2016, 6, pp.35487-35487. ⟨10.1038/srep35487⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.35487-35487. ⟨10.1038/srep35487⟩
Scientific Reports, Nature Publishing Group, 2016, 6 (1), ⟨10.1038/srep35487⟩

International audience; Loss-of-function mutations in BSCL2 are responsible for Berardinelli-Seip congenital lipodystrophy, a rare disorder characterized by near absence of adipose tissue associated with insulin resistance. Seipin-deficient (Bscl2 �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114877f70caaecc0bafed69a5587efd0

CO-20: Caractérisation de la cardiomyopathie associée à la lipodystrophie congénitale généralisée de Berardinelli-Seip

Autor: Bertrand Cariou, Michael Joubert, David Montaigne, Xavier Marechal, Xavier Prieur, Jocelyne Magré, B. Jagu, Gilles Toumaniantz, Bart Staels, Angela Tesse, C. Le May, L. Dollet

Publikováno v: Diabetes & Metabolism. 42:A6-A7

Introduction La lipodystrophie congenitale de Berardinelli-Seip (BSCL) est un syndrome rare caracterise par une absence generalisee de tissu adipeux, une insulino-resistance severe et une atteinte cardiaque encore mal caracterisee. Une des deux forme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::efffdf63a61e9d1cc6389f2f115bed30
https://doi.org/10.1016/s1262-3636(16)30038-6