Randomised, open-label, multicentric phase III trial to evaluate the safety and efficacy of palbociclib in combination with endocrine therapy, guided by ESR1 mutation monitoring in oestrogen receptor-positive, HER2-negative metastatic breast cancer patients: study design of PADA-1

Autor: C Cheneau, S Barthier, J Lemonnier, Fabrice Andre, C Dubot, L Teixeira, A Escande, T De La Motte Rouge, T Petit, L Arnould, Laurent Arnould, Suzette Delaloge, Jerome Lemonnier, A Marti, L Stefani, F Berger, C Levy, P Barthelemy, S Nguyen, M Gardner, A Lortholary, François-Clément Bidard, J Plaza, L Joly, Thibault de la Motte Rouge, F Andre, I Bièche, C Alleaume, R Sabatier, B Lucas, Ivan Bieche, O Derbel, L Venat-Bouvet, F Del Piano, Florian Clatot, Anne-Claire Hardy-Bessard, Frédérique Berger, Margaux Marce, Thomas Bachelot, Anne Pradines, Jean-Luc Canon, Sandrine Marques, M Achille, H Ammarguellat, O Arsene, T Bachelot, C Bernard-Marty, F-C Bidard, N Bonichon-Lamichhane, N Bonnin, R Bouaita, A Boudrant, V-A Brunel, C Chakiba, F Clatot, F Dalenc, A De Gramont, L Deiana, C Delbaldo, V Delecroix, H Desclos, V D'Hondt, N Dohollou, J-M Ferrero, C Foa, J-S Frenel, C Garnier Tixidre, D Genet, O Gisserot, M Gozy, C Greilsamer, J Grenier, F Guinet, A-C Hardy-Bessard, J-P Jacquin, E Lachaier, S Ladoire, A-P Laurenty, R Le Scodan, N Leduc, E Legouffe, C Levache, F Lorchel, N Marques, J Medioni, A Melis, D Mille, D Mollon, L Moreau, I Moullet, M-A Mouret-Reynier, A Najem, H Orfeuvre, J-F Paitel, B Pistilli, C Riedl, P Soulie, D Spaeth, F Trouboul, C Valmar, H Vegas, A Zannetti, FC Bidard, S Delaloge, A Pradines, JL Canon, S Marques

Publikováno v: BMJ Open, Vol 12, Iss 3 (2022)

Introduction The combination of a CDK4/6 inhibitor with an aromatase inhibitor (AI) has recently become the gold standard for AI-sensitive first line treatment of oestrogen receptor-positive (ER+) HER2-negative (HER2−) advanced breast cancer. Howev

Externí odkaz: https://doaj.org/article/8faf6bbc845f4ceeb90674dd08e198da

4 Organocatalytic Dynamic Kinetic Asymmetric Transformations

Autor: A. Córdova, K. Zhang, L. Deiana

Publikováno v: Dynamic Kinetic Resolution (DKR) and Dynamic Kinetic Asymmetric Transformations (DYKAT) ISBN: 9783132453777

Dynamic kinetic asymmetric transformations (DYKAT) are an important way of converting simple organic molecules into complex small molecules as single diastereo- and enantiomers. Herein we describe selected examples that are catalyzed by small organic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e33da3a0715bdce3970a1fe8e81fbcde
https://doi.org/10.1055/sos-sd-237-00049

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213MO Primary endpoint analysis of a randomized phase II of darolutamide or capecitabine in patients with triple-negative androgen receptor-positive advanced breast cancer (UCBG3-06 START trial)

Autor: M. Arnedos, A. Goncalves, M. Pulido, F. Lerebours, O. Tredan, F. Dalenc, S. Guiu, D. Mollon Grange, L. Teixeira, C. Levy, B. Verret, H.A.S. Dawood, P. Augereau, L. Deiana, S. Ladoire, E. Carola, M.A. Mouret Reynier, C. Guyonneau, G. MacGrogan, H. Bonnefoi

Publikováno v: Annals of Oncology. 33:S635

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6696e347d2f6ed1cecfc97a421f2f21c
https://doi.org/10.1016/j.annonc.2022.07.252

167MO Association between ER, PR and HER2 levels and outcome under palbociclib (Pal) + aromatase inhibitors (AIs) as first-line therapy for ER+ HER2- metastatic breast cancer (MBC): An exploratory analysis of the PADA-1 trial

Autor: T. De La Motte Rouge, J-S. Frenel, A-C. Hardy-Bessard, T. Bachelot, B. Pistilli, S. Delaloge, L. Deiana, F. Del Piano, D. Genet, M. Gardner, E. Legouffe, C.B. Levache, H. Orfeuvre, C. Valmar, L. Venat, A. Zannetti, R. Le Scodan, F. Dalenc, D. Berger, F.C. Bidard

Publikováno v: Annals of Oncology. 33:S200

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ab144518741305b113bb1a837adcc60
https://doi.org/10.1016/j.annonc.2022.03.186