Randomised, open-label, multicentric phase III trial to evaluate the safety and efficacy of palbociclib in combination with endocrine therapy, guided by ESR1 mutation monitoring in oestrogen receptor-positive, HER2-negative metastatic breast cancer patients: study design of PADA-1

Autor: C Cheneau, S Barthier, J Lemonnier, Fabrice Andre, C Dubot, L Teixeira, A Escande, T De La Motte Rouge, T Petit, L Arnould, Laurent Arnould, Suzette Delaloge, Jerome Lemonnier, A Marti, L Stefani, F Berger, C Levy, P Barthelemy, S Nguyen, M Gardner, A Lortholary, François-Clément Bidard, J Plaza, L Joly, Thibault de la Motte Rouge, F Andre, I Bièche, C Alleaume, R Sabatier, B Lucas, Ivan Bieche, O Derbel, L Venat-Bouvet, F Del Piano, Florian Clatot, Anne-Claire Hardy-Bessard, Frédérique Berger, Margaux Marce, Thomas Bachelot, Anne Pradines, Jean-Luc Canon, Sandrine Marques, M Achille, H Ammarguellat, O Arsene, T Bachelot, C Bernard-Marty, F-C Bidard, N Bonichon-Lamichhane, N Bonnin, R Bouaita, A Boudrant, V-A Brunel, C Chakiba, F Clatot, F Dalenc, A De Gramont, L Deiana, C Delbaldo, V Delecroix, H Desclos, V D'Hondt, N Dohollou, J-M Ferrero, C Foa, J-S Frenel, C Garnier Tixidre, D Genet, O Gisserot, M Gozy, C Greilsamer, J Grenier, F Guinet, A-C Hardy-Bessard, J-P Jacquin, E Lachaier, S Ladoire, A-P Laurenty, R Le Scodan, N Leduc, E Legouffe, C Levache, F Lorchel, N Marques, J Medioni, A Melis, D Mille, D Mollon, L Moreau, I Moullet, M-A Mouret-Reynier, A Najem, H Orfeuvre, J-F Paitel, B Pistilli, C Riedl, P Soulie, D Spaeth, F Trouboul, C Valmar, H Vegas, A Zannetti, FC Bidard, S Delaloge, A Pradines, JL Canon, S Marques

Publikováno v: BMJ Open, Vol 12, Iss 3 (2022)

Introduction The combination of a CDK4/6 inhibitor with an aromatase inhibitor (AI) has recently become the gold standard for AI-sensitive first line treatment of oestrogen receptor-positive (ER+) HER2-negative (HER2−) advanced breast cancer. Howev

Externí odkaz: https://doaj.org/article/8faf6bbc845f4ceeb90674dd08e198da

4 Organocatalytic Dynamic Kinetic Asymmetric Transformations

Autor: A. Córdova, K. Zhang, L. Deiana

Publikováno v: Dynamic Kinetic Resolution (DKR) and Dynamic Kinetic Asymmetric Transformations (DYKAT) ISBN: 9783132453777

Dynamic kinetic asymmetric transformations (DYKAT) are an important way of converting simple organic molecules into complex small molecules as single diastereo- and enantiomers. Herein we describe selected examples that are catalyzed by small organic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e33da3a0715bdce3970a1fe8e81fbcde
https://doi.org/10.1055/sos-sd-237-00049

Plasma total homocysteine and MTHFR polymorphism in young patients with myocardial infarction: [formula omitted], L. Musino 1, A. Zinellu 1, F. Galistu 1, G. Congiu 2, R. Cabiddu 2, L. Dettori 2, G. Motta 2, M.L. Stochino 2, A. Partenza 3, M. Barca 1, P.P. Bitti 4, S. Bertolini 5, L. Deiana 1, C. Carru 1, G.M. Pes 1. 1Institute of Clinical Biochemistry, University of Sassari; 2Cardiology Unit ‘Zonchello’, 3Laboratory Unit ‘Zonchello’, 4Laboratory of Tissue Typing, ASL, Nuoro; 5Department of Internal Medicine, University of Genova, Italy

Publikováno v: In Atherosclerosis (Supplements) (Component) 2002 3(2):207-207

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213MO Primary endpoint analysis of a randomized phase II of darolutamide or capecitabine in patients with triple-negative androgen receptor-positive advanced breast cancer (UCBG3-06 START trial)

Autor: M. Arnedos, A. Goncalves, M. Pulido, F. Lerebours, O. Tredan, F. Dalenc, S. Guiu, D. Mollon Grange, L. Teixeira, C. Levy, B. Verret, H.A.S. Dawood, P. Augereau, L. Deiana, S. Ladoire, E. Carola, M.A. Mouret Reynier, C. Guyonneau, G. MacGrogan, H. Bonnefoi

Publikováno v: Annals of Oncology. 33:S635

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6696e347d2f6ed1cecfc97a421f2f21c
https://doi.org/10.1016/j.annonc.2022.07.252