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Autor: Andrea Di Francesco, Donald S. Backos, David Ross, Nichole Reisdorph, David Siegel, Donna L. Dehn, Kevin Quinn, Michel Bernier, Rafael de Cabo

Publikováno v: The FASEB Journal. 32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bef1ec58b67d95eb2e8e2f47acb39b71
https://doi.org/10.1096/fasebj.2018.32.1_supplement.533.93

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p16INK4a is superior to high-risk human papillomavirus testing in cervical cytology for the prediction of underlying high-grade dysplasia

Autor: Loretta Gaido, Donna L. Dehn, Petra Homer, Chesney Thompson, Kenneth R. Shroyer, Panduka Samarawardana, Kathleen C. Torkko, Meenakshi Singh, Douglas Franquemont, Vipul Nayi, Stephanie Burke, Matthew A. Titmus

Publikováno v: Cancer Cytopathology. 118:146-156

BACKGROUND The primary goal of this study was to compare the clinical performance of an optimized and rigorously controlled immunocytochemical (ICC) assay for p16INK4a to high-risk (HR) human papillomavirus (HPV) detection by polymerase chain reactio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3d116a0ed6865d4342cb7c0c3c197a
https://doi.org/10.1002/cncy.20078

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B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration

Autor: Donna L. Dehn, T. Miyatake, Barbara Tringler, Jackie Papkoff, Takayuki Enomoto, Ashanta Swisher, Shu-Hui Liu, Kathleen C. Torkko, Kenneth R. Shroyer, Wenhui Liu

Publikováno v: Gynecologic Oncology. 106:119-127

Objectives and methods B7-H4 (DD-O110), a member of the B7 family, negatively regulates T cell-mediated immune response. Previous studies have shown that B7-H4 is highly expressed in endometrioid ovarian cancers with relatively low levels of expressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9774f32264aed54f2e85d45dd74aab7f
https://doi.org/10.1016/j.ygyno.2007.03.039

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Human papillomavirus testing and molecular markers of cervical dysplasia and carcinoma

Autor: Kenneth R. Shroyer, Donna L. Dehn, Kathleen C. Torkko

Publikováno v: Cancer. 111:1-14

Cervical cancer is the second most common cancer in women worldwide. Human papillomavirus (HPV) is the etiologic agent for the vast majority of premalignant and malignant lesions, and high-risk HPV types can be detected in almost all cases of cervica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d335a65c91e5541472cd7d225275af9d
https://doi.org/10.1002/cncr.22425

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Development of a New Isogenic Cell-Xenograft System for Evaluation of NAD(P)H:Quinone Oxidoreductase-Directed Antitumor Quinones

Autor: Donna L. Dehn, David Ross, Shannon L. Winski

Publikováno v: Clinical Cancer Research. 10:3147-3155

Purpose: The purpose of our study was to develop and validate an isogenic cell line pair that differs only in the expression of NAD(P)H:quinone oxidoreductase (NQO1) that can be used to examine the in vitro and in vivo role of NQO1 in the bioactivati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc1f2397dfe3dab0f941a2858dff5a0c
https://doi.org/10.1158/1078-0432.ccr-03-0411

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NAD(P)H:Quinone Oxidoreductase 1: Role as a Superoxide Scavenger

Autor: David Siegel, Preecha Boonchoong, Lawrence J. Berliner, David Ross, Jin Yi Han, Daniel L. Gustafson, Donna L. Dehn

Publikováno v: Molecular Pharmacology. 65:1238-1247

Experiments using purified recombinant human NAD(P)H:quinone oxidoreductase 1 (NQO1) revealed that the auto-oxidation of fully reduced protein resulted in a 1:1 stoichiometry of oxygen consumption to NADH oxidation with the production of hydrogen per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a3871a9d97d6f8cf1dd723cfb1b81d
https://doi.org/10.1124/mol.65.5.1238

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Interaction of Human NAD(P)H:Quinone Oxidoreductase 1 (NQO1) with the Tumor Suppressor Protein p53 in Cells and Cell-free Systems

Autor: David Siegel, David Ross, Luo Jia Tang, Jadwiga K. Kepa, Donna L. Dehn, Adil Anwar, Jennifer A. Pietenpol

Publikováno v: Journal of Biological Chemistry. 278:10368-10373

NAD(P)H:quinone oxidoreductase 1 (NQO1) has been proposed to stabilize p53 via a redox mechanism involving oxidation of NAD(P)H as a consequence of the catalytic activity of NQO1. We report that treatment of HCT-116 human colon carcinoma cells with t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8f4a5699338fc8df09ed28d5e8fb10
https://doi.org/10.1074/jbc.m211981200

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Akademický článek

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