Zobrazeno 1 - 10
of 21
pro vyhledávání: '"L. Dee Nord"'
Publikováno v:
Biochemical Pharmacology. 50:1943-1948
DNA-damaging agents, e.g. Adriamycin ® (ADR), are reported to cause tumor regression by induction of apoptosis. A reduction in the intracellular content of ATP is part of the biochemical cascade of events that ultimately results in programmed death
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::423e7a9112d9e81ac0832c689641abac
https://doi.org/10.1016/0006-2952(95)02094-2
https://doi.org/10.1016/0006-2952(95)02094-2
A novel non-radioactive method for detection of nucleoside analog phosphorylation by 5′-nucleotidase
Publikováno v:
Journal of Biochemical and Biophysical Methods. 25:1-10
Cytosolic 5′-nucleotidase has been implicated in the phosphorylation of certain nucleosides of therapeutic interest. In vitro, IMP and GMP serve as the optimal phosphate donors for this nucleoside phosphotransferase reaction. Existing assays for nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c714348198d002221cfdc5e54a4dc59c
https://doi.org/10.1016/0165-022x(92)90030-e
https://doi.org/10.1016/0165-022x(92)90030-e
Autor:
L. Dee Nord, Steven B. Larson, Jack D. Anderson, G. R. Revankar, Roland K. Robins, Howard B. Cottam
Publikováno v:
Journal of Heterocyclic Chemistry. 27:439-453
Synthesis of the pyrazolo[3,4-d]pyrimidin-3-one congeners of guanosine, adenosine and inosine is described. Glycosylation of 3-methoxy-6-methylthio-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (13) with 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose (16) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64273eb39a71a51ec83733d40750e636
https://doi.org/10.1002/jhet.5570270262
https://doi.org/10.1002/jhet.5570270262
Publikováno v:
Biochemical pharmacology. 51(5)
Treatment with a combination (PMA) of (N-phosphonacetyl)-L-aspartic acid (PALA), methylmercaptopurine riboside (MMPR), and 6-aminonicotinamide (6AN) induced partial regressions of CD8F1 murine mammary tumors and provided for tumor growth inhibition w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981ef07fcba2278a13237e9c081985df
https://pubmed.ncbi.nlm.nih.gov/8615898
https://pubmed.ncbi.nlm.nih.gov/8615898
Publikováno v:
Cancer investigation. 12(3)
A quadruple drug combination--consisting of a triple-drug combination of N-(phosphonacetyl)-L-aspartate (PALA) + 6-methylmercaptopurine riboside (MMPR) + 6-amino-nicotinamide (6-AN), designed to primarily deplete cellular energy in tumor cells, + Adr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f125c60424e1685dfeefc41fb60cdd2e
https://pubmed.ncbi.nlm.nih.gov/8187007
https://pubmed.ncbi.nlm.nih.gov/8187007
Autor:
Daniel S. Martin, L. Dee Nord
Publikováno v:
Biochemical pharmacology. 42(12)
The effects of 5-fluorouracil (FUra) treatment on thymidine kinase (TKase) activity were examined in vivo in CD8F1 mice bearing first generation CD8F1 mouse mammary tumors. TKase activity was not affected by low dose FUra25 (25 mg/kg), a dose which s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59057f829a424a332aef4f59b66714ad
https://pubmed.ncbi.nlm.nih.gov/1722409
https://pubmed.ncbi.nlm.nih.gov/1722409
Autor:
Ganapathi R. Revankar, L. Dee Nord, Timothy A. Riley, Donald F. Smee, Roland K. Robins, Randall C. Willis
Publikováno v:
Biochemical Pharmacology. 37:4697-4705
The nucleoside allopurinol riboside-3-thiocarboxamide (APR-TC; 4-(5 H )oxo-1-β- d -ribo-furanosylpyrazolo[3,4,d]pyrimidine-3-thiocarboxamide) demonstrates potent in vitro antiviral activity against various DNA and RNA viruses and cytostatic activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db22d20fc618ea62a5511825e07bb8ae
https://doi.org/10.1016/0006-2952(88)90340-1
https://doi.org/10.1016/0006-2952(88)90340-1
Autor:
Yogesh S. Sanghvi, Ganapathi R. Revankar, Thomas L. Avery, Timothy S. Breen, Roland K. Robins, Randall C. Willis, L. Dee Nord, Rick Avery Finch
Publikováno v:
Biochemical Pharmacology. 38:3543-3549
The basis for the antitumor activities of the exocyclic amino nucleosides 4-amino-(ARPP) and 4-methoxy-8-(D-ribofuranosylamino)pyrimido[5,4-d]pyrimidine (MRPP) was investigated. The primary target of these nucleosides appeared to be 5-phospho-alpha-D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fe0e9aa8550aff4a156cedced2ea1b
https://doi.org/10.1016/0006-2952(89)90126-3
https://doi.org/10.1016/0006-2952(89)90126-3
Autor:
Randall C. Willis, Thomas L. Avery, Yogesh S. Sanghvi, Steven S. Matsumoto, Steven B. Larson, Ganapathi R. Revankar, Roland K. Robins, Donald F. Smee, L. Dee Nord
Publikováno v:
Journal of medicinal chemistry. 32(3)
A novel and direct synthesis of the antiviral and antitumor agent 4-amino-8-(beta-D-ribofuranosylamino)pyrimido[5,4-d]pyrimidine (ARPP, 8) and its alpha-anomer (11) has been developed. Treatment of 2,4,6,8-tetrachloropyrimido[5,4-d]pyrimidine (1) wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171361fb9dda6fcb63b8804827309ffe
https://pubmed.ncbi.nlm.nih.gov/2918511
https://pubmed.ncbi.nlm.nih.gov/2918511
Autor:
Roland K. Robins, Emmanuel Ojo-Amaize, Zahra Parandoosh, Howard B. Cottam, Steven S. Matsumoto, Ganapathi R. Revankar, Donald F. Smee, James M. Fujitaki, Randall C. Willis, Boanerges Rubalcava, L. Dee Nord, Weldon B. Jolley
Publikováno v:
Advances in enzyme regulation. 29
Unlike conventional enzymes, receptors that activate G proteins do not catalyze the direct formation or cleavage of covalent bonds but act instead as a catalyst for the exchange of GTP vs GDP, which results in major conformational changes in the alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf968def23719280857f9ff7b8899b6
https://pubmed.ncbi.nlm.nih.gov/2517379
https://pubmed.ncbi.nlm.nih.gov/2517379