RosettaTMH: a method for membrane protein structure elucidation combining EPR distance restraints with assembly of transmembrane helices

Autor: Andrew Leaver-Fay, Stephanie H. DeLuca, Samuel L. DeLuca, Jens Meiler

Publikováno v: AIMS Biophysics, Vol 3, Iss 1, Pp 1-26 (2015)

Membrane proteins make up approximately one third of all proteins, and they play key roles in a plethora of physiological processes. However, membrane proteins make up less than 2% of experimentally determined structures, despite significant advances

Externí odkaz: https://doaj.org/article/5029e6a8aead46259863f1fd47f3ee14

TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.

Autor: Dorothée Diogo, Lisa Bastarache, Katherine P Liao, Robert R Graham, Robert S Fulton, Jeffrey D Greenberg, Steve Eyre, John Bowes, Jing Cui, Annette Lee, Dimitrios A Pappas, Joel M Kremer, Anne Barton, Marieke J H Coenen, Barbara Franke, Lambertus A Kiemeney, Xavier Mariette, Corrine Richard-Miceli, Helena Canhão, João E Fonseca, Niek de Vries, Paul P Tak, J Bart A Crusius, Michael T Nurmohamed, Fina Kurreeman, Ted R Mikuls, Yukinori Okada, Eli A Stahl, David E Larson, Tracie L Deluca, Michelle O'Laughlin, Catrina C Fronick, Lucinda L Fulton, Roman Kosoy, Michael Ransom, Tushar R Bhangale, Ward Ortmann, Andrew Cagan, Vivian Gainer, Elizabeth W Karlson, Isaac Kohane, Shawn N Murphy, Javier Martin, Alexandra Zhernakova, Lars Klareskog, Leonid Padyukov, Jane Worthington, Elaine R Mardis, Michael F Seldin, Peter K Gregersen, Timothy Behrens, Soumya Raychaudhuri, Joshua C Denny, Robert M Plenge

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0122271 (2015)

Despite the success of genome-wide association studies (GWAS) in detecting a large number of loci for complex phenotypes such as rheumatoid arthritis (RA) susceptibility, the lack of information on the causal genes leaves important challenges to inte

Externí odkaz: https://doaj.org/article/beb6d79c3e184701a89299ca92e0df4f

Pneumothorax and pneumoperitoneum during the apnea test: how safe is this procedure? Pneumotorax y pneumoperitoneo durante el test de apnea: cuán seguro es este procedimiento?

Autor: GUSTAVO SAPOSNIK, GRACIELA RIZZO, JORGE L. DELUCA

Publikováno v: Arquivos de Neuro-Psiquiatria, Vol 58, Iss 3B, Pp 905-908 (2000)

Apnea test is a crucial requirement for determining the diagnosis of brain death (BD). There are few reports considering clinical complications during this procedure. We describe a major complication during performing the apnea test. We also analyse

Externí odkaz: https://doaj.org/article/3a31a01474f541e5832ca6fee093ff9e

Brief Report: The Role of Rare Protein‐Coding Variants in Anti–Tumor Necrosis Factor Treatment Response in Rheumatoid Arthritis

Autor: João Eurico Fonseca, Michelle O'Laughlin, Catrina Fronick, Yukinori Okada, Robert S. Fulton, Soumya Raychaudhuri, Tom W J Huizinga, Eli A. Stahl, Dimitrios A. Pappas, Robert M. Plenge, Peter K. Gregersen, Gertjan Wolbink, Joel M. Kremer, Jeff Greenberg, Corinne Miceli-Richard, David E. Larson, Niek de Vries, Dorothée Diogo, Tracie L. Deluca, Michael T. Nurmohamed, Paul P. Tak, Lucinda Fulton, Anne Barton, Fina A S Kurreeman, Elizabeth W. Karlson, Annette Lee, Helena Canhão, Marieke J H Coenen, Elaine R. Mardis, Xavier Mariette, Irene E. van der Horst-Bruinsma, Jing Cui, J. Bart A. Crusius

Publikováno v: Arthritis & rheumatology (Hoboken, N.J.), 69(4), 735-741. John Wiley and Sons Ltd
Arthritis & Rheumatology, 69, 735-741
Arthritis & Rheumatology, 69, 4, pp. 735-741

Item does not contain fulltext OBJECTIVE: In many rheumatoid arthritis (RA) patients, disease is controlled with anti-tumor necrosis factor (anti-TNF) biologic therapies. However, in a significant number of patients, the disease fails to respond to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3afec6759e5f5f9ac2e0ed1753ef28e
https://doi.org/10.1002/art.39966

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