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GWAS for executive function and processing speed suggests involvement of the CADM2 gene

Autor: Igor Rudan, Daniel I. Chasman, Helena Schmidt, Stefan Herms, Sharon L.R. Kardia, Oliver Stegle, Alison Pattie, Jenna Price, Gerardo Heiss, Karen A. Mather, L. J. Launer, Johan G. Eriksson, Christopher Oldmeadow, Ian Ford, Saira Saeed Mirza, Alan F. Wright, Ozren Polasek, Joshua M. Shulman, Maria K. Jonsdottir, André G. Uitterlinden, Rodney J. Scott, Kurt Lohman, Anita L. DeStefano, Peter W. Schofield, Perminder S. Sachdev, Stefania Bandinelli, Johan Wouter Jukema, John M. Starr, Rudolf S N Fehrmann, Y. C. Hsieh, William M. Meeks, Paul M. Ridker, R.G.J. Westendorp, Le Yu, J. C. van Swieten, Vilmundur Gudnason, Myriam Fornage, Melissa Garcia, Carla A. Ibrahim-Verbaas, James F. Wilson, Jean-Charles Lambert, Qiong Yang, Laura H. Coker, Stella Trompet, Lina Zgaga, Jennifer A. Smith, David J. Llewellyn, Nicole A. Kochan, Ben A. Oostra, Katja Petrovic, Peter Hoffmann, Qi Sun, James T. Becker, Najaf Amin, Vincent Chouraki, Brendan M. Buckley, D C Liewald, Jun Ding, Christiane Wolf, P. L. DeJager, Reinhold Schmidt, Chloe Fawns-Ritchie, Stéphanie Debette, Jing Wang, J. C. Bis, Nicola J. Armstrong, David J. Stott, Albert Hofman, Nazanin Karbalai, G. Eiriksdottir, Luke C. Pilling, D. S. Knopman, Maaike Schuur, Alexa S. Beiser, Annette L. Fitzpatrick, David A. Bennett, Aarno Palotie, Lude Franke, Sven Cichon, Mirna Kirin, Markus M. Nöthen, Thomas H. Mosley, Lynda M. Rose, Alan J. Gow, Caroline Hayward, Lori B. Chibnik, Ian J. Deary, Albert V. Smith, Jan Bressler, T.B. Harris, Stephen T. Turner, David J. Porteous, C M van Duijn, M. A. Ikram, Elizabeth G. Holliday, Mike A. Nalls, Luigi Ferrucci, Sudha Seshadri, Francine Grodstein, Marlene C. W. Stewart, Philip A. Wolf, Alexander Teumer, P.E. Slagboom, Jerome I. Rotter, Blair H. Smith, Juha Karjalainen, Susan M. Resnick, A.J.M. de Craen, Toshiko Tanaka, Alan D. Penman, Hans-Jörgen Grabe, Gary Davies, Oscar L. Lopez, Yongmei Liu, Kristine Yaffe, Veronique Vitart, Stela McLachlan, Katri Räikkönen, Rebecca F. Gottesman, Rhoda Au, Lynne J. Hocking, Carsten Oliver Schmidt, John Attia, Bruce M. Psaty, Wei Zhao, Jari Lahti

Publikováno v: Molecular Psychiatry, 21(2), 189-197. Nature Publishing Group
Molecular Psychiatry, 21(2), 189-197
Ibrahim-Verbaas, C A, Bressler, J, Debette, S, Schuur, M, Smith, A V, Bis, J C, Davies, G, Trompet, S, Smith, J A, Wolf, C, Chibnik, L B, Liu, Y, Vitart, V, Kirin, M, Petrovic, K, Polasek, O, Zgaga, L, Fawns-Ritchie, C, Hoffmann, P, Karjalainen, J, Lahti, J, Llewellyn, D J, Schmidt, C O, Mather, K A, Chouraki, V, Sun, Q, Resnick, S M, Rose, L M, Oldmeadow, C, Stewart, M, Smith, B H, Gudnason, V, Yang, Q, Mirza, S S, Jukema, J W, deJager, P L, Harris, T B, Liewald, D, Amin, N, Gow, A J, Pattie, A, Starr, J M, McLachlan, S, Porteous, D J, Price, J F, Rudan, I, Hayward, C, Wright, A F & Wilson, J F & Deary, I 2016, ' GWAS for executive function and processing speed suggests involvement of the CADM2 gene ', Molecular Psychiatry, vol. 21, pp. 189-197 . https://doi.org/10.1038/mp.2015.37
Ibrahim-Verbaas, CA; Bressler, J; Debette, S; Schuur, M; Smith, AV; Bis, JC; et al.(2016). GWAS for executive function and processing speed suggests involvement of the CADM2 gene. MOLECULAR PSYCHIATRY, 21(2), 189-197. doi: 10.1038/mp.2015.37. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7d8152n1
Molecular psychiatry 21(2), 189-197 (2015). doi:10.1038/mp.2015.37
Neurology Working Group of the CHARGE Consortium 2016, ' GWAS for executive function and processing speed suggests involvement of the CADM2 gene ', Molecular Psychiatry, vol. 21, no. 2, pp. 189-197 . https://doi.org/10.1038/mp.2015.37
Molecular psychiatry 21, 189–197 (2016). doi:10.1038/mp.2015.37

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access. To identify common variants contributing to n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf11a1a3e166a98f0a244478f602cbf
https://hdl.handle.net/11370/3faba094-c578-4ed8-8cab-cb46bcdc7740

Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer’s Disease Risk Factors in Yeast

Autor: Chee Yeun Chung, Antonio R. Parrado, David A. Bennett, Sebastian Treusch, Guy A. Caldwell, Anders Olofsson, Joshua M. Shulman, Eric M. Reiman, Rudolph E. Tanzi, Denis A. Evans, Haesun Han, Susan Lindquist, Julie S. Valastyan, Valeriya Baru, Philip L. DeJager, Kent E. S. Matlack, Kim A. Caldwell, Shusei Hamamichi, Jessica L. Goodman, Brooke J. Bevis, Malin Lindhagen-Persson

Publikováno v: Science. 334:1241-1245

Aβ (beta-amyloid peptide) is an important contributor to Alzheimer's disease (AD). We modeled Aβ toxicity in yeast by directing the peptide to the secretory pathway. A genome-wide screen for toxicity modifiers identified the yeast homolog of phosph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594848704371a403f8184ef52b262667
https://doi.org/10.1126/science.1213210

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A Novel Protein Complex Linking the δ2 Glutamate Receptor and Autophagy

Autor: Monica Bravin, Philip L. DeJager, Antony Horton, Fekrije Selimi, Nathaniel Heintz, Zhenyu Yue

Publikováno v: Neuron. 35(5):921-933

Autophagy is a pathway for bulk degradation of subcellular constituents that is hyperactivated in many neurodegenerative conditions. It has been considered a second form of programmed cell death. Death of cerebellar Purkinje cells in lurcher animals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a089483cc08806e3c06dd9981d32e2ab