Zobrazeno 1 - 10
of 931
pro vyhledávání: '"L. De Jager"'
Autor:
Kwangsik Nho, Shannon L. Risacher, Liana G. Apostolova, Paula J. Bice, Jared R. Brosch, Rachael Deardorff, Kelley Faber, Martin R. Farlow, Tatiana Foroud, Sujuan Gao, Thea Rosewood, Jun Pyo Kim, Kelly Nudelman, Meichen Yu, Paul Aisen, Reisa Sperling, Basavaraj Hooli, Sergey Shcherbinin, Diana Svaldi, Clifford R. Jack, William J. Jagust, Susan Landau, Aparna Vasanthakumar, Jeffrey F. Waring, Vincent Doré, Simon M. Laws, Colin L. Masters, Tenielle Porter, Christopher C. Rowe, Victor L. Villemagne, Logan Dumitrescu, Timothy J. Hohman, Julia B. Libby, Elizabeth Mormino, Rachel F. Buckley, Keith Johnson, Hyun-Sik Yang, Ronald C. Petersen, Vijay K. Ramanan, Nilüfer Ertekin-Taner, Prashanthi Vemuri, Ann D. Cohen, Kang-Hsien Fan, M. Ilyas Kamboh, Oscar L. Lopez, David A. Bennett, Muhammad Ali, Tammie Benzinger, Carlos Cruchaga, Diana Hobbs, Philip L. De Jager, Masashi Fujita, Vaishnavi Jadhav, Bruce T. Lamb, Andy P. Tsai, Isabel Castanho, Jonathan Mill, Michael W. Weiner, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI), the Department of Defense Alzheimer’s Disease Neuroimaging Initiative (DoD-ADNI), the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Study (A4 Study) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN), the Australian Imaging, Biomarker & Lifestyle Study (AIBL), Andrew J. Saykin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Determining the genetic architecture of Alzheimer’s disease pathologies can enhance mechanistic understanding and inform precision medicine strategies. Here, we perform a genome-wide association study of cortical tau quantified by positron
Externí odkaz:
https://doaj.org/article/534dba93d5bf4620975ce9a0f564baf7
Autor:
Qiang Chen, Luis Aguirre, Guoming Liang, Huanhuan Zhao, Tao Dong, Felix Borrego, Itziar de Rojas, Qichan Hu, Christopher Reyes, Ling-Yan Su, Bao Zhang, James D. Lechleiter, Harald H. H. Göring, Philip L. De Jager, Joel E. Kleinman, Thomas M. Hyde, Pan P. Li, Agustín Ruiz, Daniel R. Weinberger, Sudha Seshadri, Liang Ma
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-18 (2024)
Abstract Background The APOE gene is the strongest genetic risk factor for late-onset Alzheimer’s Disease (LOAD). However, the gene regulatory mechanisms at this locus remain incompletely characterized. Methods To identify novel AD-linked functiona
Externí odkaz:
https://doaj.org/article/5374844758ed40dc95d178d7f3ae89ee
Autor:
Randy L. Parrish, Aron S. Buchman, Shinya Tasaki, Yanling Wang, Denis Avey, Jishu Xu, Philip L. De Jager, David A. Bennett, Michael P. Epstein, Jingjing Yang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Multiple reference panels of a given tissue or multiple tissues often exist, and multiple regression methods could be used for training gene expression imputation models for transcriptome-wide association studies (TWAS). To leverage expressi
Externí odkaz:
https://doaj.org/article/e1438fafdf334bde867c5aecd9114757
Single cell transcriptomes and multiscale networks from persons with and without Alzheimer’s disease
Autor:
Qi Wang, Jerry Antone, Eric Alsop, Rebecca Reiman, Cory Funk, Jaroslav Bendl, Joel T. Dudley, Winnie S. Liang, Timothy L. Karr, Panos Roussos, David A. Bennett, Philip L. De Jager, Geidy E. Serrano, Thomas G. Beach, Kendall Van Keuren-Jensen, Diego Mastroeni, Eric M. Reiman, Benjamin P. Readhead
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The emergence of single nucleus RNA sequencing (snRNA-seq) offers to revolutionize the study of Alzheimer’s disease (AD). Integration with complementary multiomics data such as genetics, proteomics and clinical data provides powerful oppor
Externí odkaz:
https://doaj.org/article/583e7a46c0434985a97259a70db5d4e3
Autor:
Francine Grodstein, Bernardo Lemos, Jingyun Yang, Katia de Paiva Lopes, Ricardo A. Vialle, Nicholas Seyfried, Yanling Wang, Gemma Shireby, Eilis Hannon, Alan Thomas, Keeley Brookes, Jonathan Mill, Philip L. De Jager, David A. Bennett
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
The cortical epigenetic clock was developed in brain tissue as a biomarker of brain aging. As one way to identify mechanisms underlying aging, we conducted a GWAS of cortical age. We leveraged postmortem cortex tissue and genotyping array data from 6
Externí odkaz:
https://doaj.org/article/3bd3ed164ebf4211abfa1877dd14702f
Autor:
Shahram Oveisgharan, Lei Yu, Katia de Paiva Lopes, Vladislav A. Petyuk, Shinya Tasaki, Ricardo Vialle, Vilas Menon, Yanling Wang, Philip L. De Jager, Julie A. Schneider, David A. Bennett
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Accumulation of amyloid-β (Aβ) and tau tangles are hallmarks of Alzheimer’s disease. Aβ is extracellular while tau tangles are typically intracellular, and it is unknown how these two proteinopathies are connected. Here, we use data of
Externí odkaz:
https://doaj.org/article/db373cb64bd548c290a7761d99ec2353
Autor:
Weichen Zhou, Kalpita R Karan, Wenjin Gu, Hans-Ulrich Klein, Gabriel Sturm, Philip L De Jager, David A Bennett, Michio Hirano, Martin Picard, Ryan E Mills
Publikováno v:
PLoS Biology, Vol 22, Iss 8, p e3002723 (2024)
The transfer of mitochondrial DNA into the nuclear genomes of eukaryotes (Numts) has been linked to lifespan in nonhuman species and recently demonstrated to occur in rare instances from one human generation to the next. Here, we investigated numtoge
Externí odkaz:
https://doaj.org/article/eea7e63066f54cc38b1e1e976ca6657e
Autor:
Jonas Rybnicek, Yuxiao Chen, Milos Milic, Earvin S. Tio, JoAnne McLaurin, Timothy J. Hohman, Philip L. De Jager, Julie A. Schneider, Yanling Wang, David A. Bennett, Shreejoy Tripathy, Daniel Felsky, Evelyn K. Lambe
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Changes in high-affinity nicotinic acetylcholine receptors are intricately connected to neuropathology in Alzheimer’s Disease (AD). Protective and cognitive-enhancing roles for the nicotinic α5 subunit have been identified, but this gene
Externí odkaz:
https://doaj.org/article/f374cbbc47054ea0a3ea6f1c0e8deae1
Autor:
Vicky Chou, Richard V. Pearse, Aimee J. Aylward, Nancy Ashour, Mariko Taga, Gizem Terzioglu, Masashi Fujita, Seeley B. Fancher, Alina Sigalov, Courtney R. Benoit, Hyo Lee, Matti Lam, Nicholas T. Seyfried, David A. Bennett, Philip L. De Jager, Vilas Menon, Tracy L. Young-Pearse
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Microglia and neuroinflammation play an important role in the development and progression of Alzheimer’s disease (AD). Inositol polyphosphate-5-phosphatase D (INPP5D/SHIP1) is a myeloid-expressed gene genetically-associated with AD. Throug
Externí odkaz:
https://doaj.org/article/9e3d8cd8d32347f6b00af0ac1594f3b7
Autor:
Hyun-Sik Yang, Ling Teng, Daniel Kang, Vilas Menon, Tian Ge, Hilary K. Finucane, Aaron P. Schultz, Michael Properzi, Hans-Ulrich Klein, Lori B. Chibnik, Julie A. Schneider, David A. Bennett, Timothy J. Hohman, Richard P. Mayeux, Keith A. Johnson, Philip L. De Jager, Reisa A. Sperling
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Many of the Alzheimer’s disease (AD) risk genes are specifically expressed in microglia and astrocytes, but how and when the genetic risk localizing to these cell types contributes to AD pathophysiology remains unclear. Here, we derive cel
Externí odkaz:
https://doaj.org/article/0e512e3890b148e388c778ba58f1e579