Zobrazeno 1 - 10
of 8 385
pro vyhledávání: '"L. De Groot"'
Publikováno v:
eLife, Vol 12 (2024)
Aquaporin-0 (AQP0) tetramers form square arrays in lens membranes through a yet unknown mechanism, but lens membranes are enriched in sphingomyelin and cholesterol. Here, we determined electron crystallographic structures of AQP0 in sphingomyelin/cho
Externí odkaz:
https://doaj.org/article/da574ef9e6f64e36b5620f82a9a767c6
Autor:
Carlyn V. Kouwenberg, Julia Spierings, Evianne L. de Groot, Joke H. de Boer, Viera Kalinina Ayuso
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 21, Iss 1, Pp 1-9 (2023)
Abstract Background Pediatric uveitis is a severe inflammatory ocular condition that can lead to sight-threatening complications and can negatively impact quality of life. The retinal microcirculation is often affected in intermediate uveitis and pan
Externí odkaz:
https://doaj.org/article/0da3e17bef124cbab2a6f01b1e336c63
Autor:
J. Harry Moore, Christian Margreitter, Jon Paul Janet, Ola Engkvist, Bert L. de Groot, Vytautas Gapsys
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract In drug discovery, computational methods are a key part of making informed design decisions and prioritising experiments. In particular, optimizing compound affinity is a central concern during the early stages of development. In the last 10
Externí odkaz:
https://doaj.org/article/e61fcb9fe4934f0ebbdda11498708408
Autor:
Ruo-Xu Gu, Bert L. de Groot
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The hydrophobic gating model, in which ion permeation is inhibited by the hydrophobicity, rather than a physical occlusion of the nanopore, functions in various ion channels including potassium channels. Available research focused on the ene
Externí odkaz:
https://doaj.org/article/33848e8d18d9497e9ca8d26c13f664c6
Autor:
Benedikt Frieg, Leif Antonschmidt, Christian Dienemann, James A. Geraets, Eszter E. Najbauer, Dirk Matthes, Bert L. de Groot, Loren B. Andreas, Stefan Becker, Christian Griesinger, Gunnar F. Schröder
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Interactions between α-synuclein fibrils and lipids have been associated with the development of Parkinson’s disease. This cryo-EM study reveals structural details of these interactions and suggests a mechanism for fibril-induced lipid extraction.
Externí odkaz:
https://doaj.org/article/370fbaf8c903466ab28670a017457f67
Autor:
Leif Antonschmidt, Dirk Matthes, Rıza Dervişoğlu, Benedikt Frieg, Christian Dienemann, Andrei Leonov, Evgeny Nimerovsky, Vrinda Sant, Sergey Ryazanov, Armin Giese, Gunnar F. Schröder, Stefan Becker, Bert L. de Groot, Christian Griesinger, Loren B. Andreas
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Understanding how small molecules bind to pathological aggregates is of importance for therapeutic and diagnostic development in diseases such as Parkinson’s Disease. Here, the authors reveal a binding site of anle138b to lipid-induced α-synuclein
Externí odkaz:
https://doaj.org/article/ed3eab20b6124a5585faf679ec466929
Autor:
Kalyan S. Chakrabarti, Simon Olsson, Supriya Pratihar, Karin Giller, Kerstin Overkamp, Ko On Lee, Vytautas Gapsys, Kyoung-Seok Ryu, Bert L. de Groot, Frank Noé, Stefan Becker, Donghan Lee, Thomas R. Weikl, Christian Griesinger
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The authors provide a litmus test for the recognition mechanism of transiently binding proteins based on nuclear magnetic resonance and find a conformational selection binding mechanism through concentration-dependent kinetics of ubiquitin and SH3.
Externí odkaz:
https://doaj.org/article/e8ba332421814557b30a7a29637552f0
Autor:
Viviane Zulian, Andrea R. Norris, Kristina L. Cockle, Alison N. Porter, Lauryn G. Do, Krista L. De Groot
Publikováno v:
Avian Conservation and Ecology, Vol 18, Iss 2, p 15 (2023)
We examined the effects of façade-level building and vegetation features on bird-window collision risk, and how these effects varied across seasons at a Pacific coastal campus with mild winters, abundant evergreen vegetation, and seasonally varied b
Externí odkaz:
https://doaj.org/article/beb7efbcfc854d6fb15deb2c4c34beda
Autor:
Jenny Kaur Singh, Rebecca Smith, Magdalena B. Rother, Anton J. L. de Groot, Wouter W. Wiegant, Kees Vreeken, Ostiane D’Augustin, Robbert Q. Kim, Haibin Qian, Przemek M. Krawczyk, Román González-Prieto, Alfred C. O. Vertegaal, Meindert Lamers, Sébastien Huet, Haico van Attikum
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Classical non-homologous end-joining (cNHEJ) is the dominant pathway used by human cells to repair DNA double-strand breaks (DSBs) and maintain genome stability. Here the authors show that PARP1-driven chromatin expansion allows the recruitment of ZN
Externí odkaz:
https://doaj.org/article/81eb6422ad4941fe875820f223a85fd7
Autor:
Vytautas Gapsys, Ahmet Yildirim, Matteo Aldeghi, Yuriy Khalak, David van der Spoel, Bert L. de Groot
Publikováno v:
Communications Chemistry, Vol 4, Iss 1, Pp 1-13 (2021)
Molecular dynamics-based approaches to calculate absolute protein–ligand binding free energy often rely on equilibrium free energy perturbation (FEP) protocols. Here, the authors study ligands binding to bromodomains and T4 lysozyme and find that b
Externí odkaz:
https://doaj.org/article/53ecbf2eedd34149bc3dad8e7658da0f