Zobrazeno 1 - 10
of 640
pro vyhledávání: '"L. Darryl"'
Osteocalcin binds to a GPRC6A Venus fly trap allosteric site to positively modulate GPRC6A signaling
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 9, Pp 365-376 (2024)
Abstract GPRC6A, a member of the Family C G‐protein coupled receptors, regulates energy metabolism and sex hormone production and is activated by diverse ligands, including cations, L‐amino acids, the osteocalcin (Ocn) peptide and the steroid hor
Externí odkaz:
https://doaj.org/article/6595614307174a96a72a2183c31401dd
Autor:
Min Pi, Fuyi Xu, Ruisong Ye, Satoru K. Nishimoto, Robert A. Kesterson, Robert W. Williams, Lu Lu, L. Darryl Quarles
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract GPRC6A is proposed to regulate energy metabolism in mice, but in humans a KGKY polymorphism in the third intracellular loop (ICL3) is proposed to result in intracellular retention and loss-of-function. To test physiological importance of thi
Externí odkaz:
https://doaj.org/article/3ed251cfeccd48bdb84fed80a49a4f2a
Autor:
J. Pinthus, B. Shayegan, L. Klotz, R. Siemens, P. Luke, T. Niazi, V. Fradet, Y. Fradet, E. Duceppe, L. Lavallee, N. Mousavi, R. Hamilton, I. Brown, D. Gopaul, P. Violette, M. Davis, R. Mian, S. Karampatos, L. Darryl
Publikováno v:
European Urology Open Science, Vol 19, Iss , Pp e2106- (2020)
Externí odkaz:
https://doaj.org/article/9d0cfcc7f0b54369bd90c35d40f1b7e5
Autor:
Csaba P. Kovesdy, Jun Ling Lu, Barry M. Wall, Geeta Gyamlani, Adnan Naseer, Angela Wallick, Zhongji Han, Fridtjof Thomas, L. Darryl Quarles, Nabil Jarmukli
Publikováno v:
Kidney International Reports, Vol 3, Iss 4, Pp 897-904 (2018)
Introduction: Abnormal phosphorus homeostasis develops early in chronic kidney disease (CKD). It is unclear if its correction results in improved clinical outcomes in non–dialysis dependent CKD. Methods: We conducted a randomized controlled, parall
Externí odkaz:
https://doaj.org/article/48f2df5ac81046e4a64e43dd02de4159
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 36, Iss 1, Pp 1-13 (2017)
Abstract Background GPRC6A is implicated in the pathogenesis of prostate cancer, but its role remains uncertain because of a purported tolerant gene variant created by substitution of a K..Y polymorphism in the 3rd intracellular loop (IL) that evolve
Externí odkaz:
https://doaj.org/article/7b36bab953df4ababec9f201e7142b93
Publikováno v:
Molecular Metabolism, Vol 6, Iss 2, Pp 185-193 (2017)
Background: GPRC6A, a widely expressed G-protein coupled receptor, is proposed to be a master regulator of complex endocrine networks and metabolic processes. GPRC6A is activated by multiple ligands, including osteocalcin (Ocn), testosterone (T), bas
Externí odkaz:
https://doaj.org/article/f354a9fb1b724a8b80e2870fc0fbd895
Autor:
Xusheng Wang, Ashutosh K. Pandey, Megan K. Mulligan, Evan G. Williams, Khyobeni Mozhui, Zhengsheng Li, Virginija Jovaisaite, L. Darryl Quarles, Zhousheng Xiao, Jinsong Huang, John A. Capra, Zugen Chen, William L. Taylor, Lisa Bastarache, Xinnan Niu, Katherine S. Pollard, Daniel C. Ciobanu, Alexander O. Reznik, Artem V. Tishkov, Igor B. Zhulin, Junmin Peng, Stanley F. Nelson, Joshua C. Denny, Johan Auwerx, Lu Lu, Robert W. Williams
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Phenome-wide association is a novel method that links sequence variants to a spectrum of phenotypes and diseases. Here the authors generate detailed mouse genetic and phenome data which links their phenome-wide association study (PheWAS) of mouse to
Externí odkaz:
https://doaj.org/article/cfc59303336541d2b8ee796f1a6ebb5b
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Fibroblast growth factor-23 (FGF-23) is a bone-derived hormone that activates FGFR/α-Klotho binary complexes in the kidney renal tubules to regulate phosphate reabsorption and vitamin D metabolism. The objective of this review is to discuss the emer
Externí odkaz:
https://doaj.org/article/d92db2faec69428a8932927b277d5376
Autor:
Zhongji Han, Zhousheng Xiao, Kamyar Kalantar-Zadeh, Hamid Moradi, Tariq Shafi, Sushrut S. Waikar, L. Darryl Quarles, Zhi Yu, Adrienne Tin, Josef Coresh, Csaba P. Kovesdy
Publikováno v:
Diagnostics, Vol 8, Iss 4, p 71 (2018)
End stage renal disease (ESRD) is characterized by complex metabolic abnormalities, yet the clinical relevance of specific biomarkers remains unclear. The development of multiplex diagnostic platforms is creating opportunities to develop novel diagno
Externí odkaz:
https://doaj.org/article/72d86e86273043ae854dacd87e041868
Publikováno v:
In Trends in Pharmacological Sciences December 2023 44(12):862-864