Zobrazeno 1 - 10 of 103 pro vyhledávání: '"L. D. Kohn"'
2
Epitopes for thyroid-stimulating antibodies in Graves' sera: a possible link of heterogeneity to differences in response to antithyroid drug treatment
Autor: Hong Kyu Lee, Chang Soon Koh, H Y Park, K Tahara, Bo Youn Cho, Won Bae Kim, L D Kohn
Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 81:1758-1767
To evaluate the extent and clinical relevance of epitope heterogeneity for stimulating TSH receptor antibodies (TSHRAbs), we measured the activity of IgG preparations from 66 untreated patients with Graves' disease using Chinese hamster ovary (CHO) c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd8b337b8e11e634fff7ce7e2a344fe
https://doi.org/10.1210/jcem.81.5.8626830
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3
The thyrotropin (TSH) receptor transmembrane domain mutation (Pro556-Leu) in the hypothyroid hyt/hyt mouse results in plasma membrane targeting but defective TSH binding
Autor: Guo-Guang Du, L. D. Kohn, A. Rentoumis, Peter Kopp, J L Jameson, Wen-Xia Gu, Laird D. Madison, Chris Albanese
Publikováno v: Endocrinology. 136:3146-3153
The hyt/hyt mouse is hypothyroid because of a mutation in the TSH receptor (TSH-R). In this report, we confirm the presence of a Pro to Leu mutation in amino acid 556 of the fourth transmembrane domain (TM4) of the TSH-R. This Pro is highly conserved
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ea6cf2e67ff57495ca3458b374ba13
https://doi.org/10.1210/endo.136.7.7789342
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4
Periocular inflammation in mice with experimental systemic lupus erythematosus. A new experimental blepharitis and its modulation
Autor: C C Chan, I Gery, L D Kohn, R B Nussenblatt, E Mozes, D S Singer
Publikováno v: The Journal of Immunology. 154:4830-4835
Experimental systemic lupus erythematosus (SLE) can be induced in mice by immunization with a human monoclonal anti-DNA Ab, bearing a major Id 16/6Id. Immunized mice initially produce Abs to 16/6Id, DNA and nuclear Ags, and subsequently develop vario
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11388f46290dafabe09703f016d8ae88
https://doi.org/10.4049/jimmunol.154.9.4830
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5
Methimazole prevents induction of experimental systemic lupus erythematosus in mice
Autor: D S Singer, L D Kohn, H Zinger, E Mozes
Publikováno v: The Journal of Immunology. 153:873-880
Experimental SLE can be induced in mice by immunization with a human mAb to DNA (16/6Id). Immunized mice develop Abs to the 16/6Id immunogen, DNA, and nuclear Ags. Subsequently, clinical manifestations of disease develop, including leukopenia, protei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::115edd9d8a8ef690782c17780810d0e6
https://doi.org/10.4049/jimmunol.153.2.873
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6
Peptide sequences from the hypervariable regions of two monoclonal anti-idiotypic antibodies against the thyrotropin (TSH) receptor are similar to TSH and inhibit TSH-increased cAMP production in FRTL-5 thyroid cells
Autor: B. L. Hill, Jui-Chou Hsu, Rebecca Taub, B. F. Erlanger, L. D. Kohn, V. M. Garsky
Publikováno v: Journal of Biological Chemistry. 267:5977-5984
Monoclonal antibodies, D2 and 4G11, selected by the autoantiidiotypic approach following injection of thyrotropin (TSH) into mice, mimic TSH in binding to receptors on thyroid membranes. Based on TSH receptor transfection studies, D2 and 4G11 show un
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c47f74a5bc501eaa91196db21192452f
https://doi.org/10.1016/s0021-9258(18)42651-8
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9
Hashimoto's thyroiditis with heterogeneous antithyrotropin receptor antibodies: unique epitopes may contribute to the regulation of thyroid function by the antibodies
Autor: T, Akamizu, L D, Kohn, H, Hiratani, M, Saijo, K, Tahara, K, Nakao
Publikováno v: The Journal of clinical endocrinology and metabolism. 85(6)
Blocking-type TSH-binding inhibitor Igs (TBIIs) are known to cause hypothyroidism and an atrophic thyroid gland in patients with primary myxedema. They can block the activity of thyroid-stimulating antibodies (TSAbs) in Graves' patients as well as th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62ef26cf1b961bfc81b47eef2fb3d1df
https://pubmed.ncbi.nlm.nih.gov/10852437
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10
Thymosin-alpha1 regulates MHC class I expression in FRTL-5 cells at transcriptional level
Autor: C, Giuliani, G, Napolitano, A, Mastino, S, Di Vincenzo, C, D'Agostini, S, Grelli, I, Bucci, D S, Singer, L D, Kohn, F, Monaco, E, Garaci, C, Favalli
Publikováno v: European journal of immunology. 30(3)
In this study we examined the effect of the synthetic peptide thymosin-alpha1 (T(alpha)1) on MHC class I expression in FRTL-5 cells. Treatment with T(alpha)1 increased expression of MHC class I surface molecules and mRNA, which reached its peak (153
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7958a7caa154a39468a8be5274089edf
https://pubmed.ncbi.nlm.nih.gov/10741392
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