Zobrazeno 1 - 10 of 13 pro vyhledávání: '"L. D. Hawkins"'
1
Anti-endotoxin activity of a novel synthetic lipid A analog
Autor: T, Kawata, J R, Bristol, J R, Rose, D P, Rossignol, W J, Christ, O, Asano, G R, Dubuc, W E, Gavin, L D, Hawkins, Y, Kishi
Publikováno v: Progress in clinical and biological research. 392
Lipid As from non-toxic bacteria such as Rhodobacter capsulatus and Rhodobacter sphaeroides have been shown to antagonize the immunostimulatory effects of lipid A and LPS from pathogenic bacteria. We have biologically characterized a series of synthe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::53d7c4abd31729a7d7272fb26eb61010
https://pubmed.ncbi.nlm.nih.gov/8524958
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2
Coupling of the C5a receptor to Gi in U-937 cells and in cells transfected with C5a receptor cDNA
Autor: M, Vanek, L D, Hawkins, F, Gusovsky
Publikováno v: Molecular pharmacology. 46(5)
The signaling properties of the receptor for the chemoattractant C5a (C5aR) were investigated in differentiated U-937 cells and in NIH/3T3 cells transfected with the C5aR. In both U-937 cells and transfected cells (2A3 cells), C5a induced the mobiliz
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::95b9b4bec3e03321c4f4505e77538ca9
https://pubmed.ncbi.nlm.nih.gov/7969069
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5
Inhibitors of Adenosine Deaminase: Synthesis of Coformycin and 3′-Deoxycoformycin
Autor: David C. Baker, J. C. Hanvey, L. D. Hawkins, F. L. Boyd, H. D. Hollis Showalter
Publikováno v: Nucleosides and Nucleotides. 2:479-494
Glycosylation of the heterocycle, 6,7-dihydro-imidazo [4,5-d] [1,3] diazepin-8(3H)-one, with suitably protected sugars under the influence of Lewis acid catalysts gave the β-D-ribo- and 3′-deoxy-β-D-erythropento-furanosyl nucleosides. Deprotectio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc5667c94526b401d448c3ab01b50deb
https://doi.org/10.1080/07328318308079413
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6
Total synthesis of palytoxin carboxylic acid and palytoxin amide
Autor: Robert W. Armstrong, L. D. Hawkins, Haolun Jin, Hiromichi Fujioka, Sung Ho Kang, W. J. Christ, Seung Hoon Cheon, Jean Marie Beau, Won Hun Ham
Publikováno v: Journal of the American Chemical Society. 111:7530-7533
The total synthesis of palytoxin carboxylic acid and palytoxin amide was achieved from the fully protected palytoxin carboxylic acid. The fully protected palytoxin carboxylic acid 1 contains eight different and 42 total protecting groups. All these p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::709476758a484c5e2895534a67f448d3
https://doi.org/10.1021/ja00201a038
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7
A practical synthesis of trans-iodoolefins
Autor: Seung Hoon Cheon, Yoshito Kishi, Mikio Taniguchi, William J. Christ, L. D. Hawkins, Haolun Jin
Publikováno v: Tetrahedron Letters. 27:4759-4762
Trimethylsilyl iodide was found to react smoothly with the acetylenic ketones 3 and 6 to yield the trans-β-iodovinyl ketones 4 and 7 , respectively. Hydride reduction of 4 and 7 gave the trans-iodoolefins 5 and 8 , which correspond to the C.19–C.2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfa462e38eb0af101192cb33d605b0e0
https://doi.org/10.1016/s0040-4039(00)85058-3
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9
Total synthesis of a fully protected palytoxin carboxylic acid
Autor: M. Yonaga, Sung Ho Kang, F. X. Talamas, W. W. McWhorter Jr., K. Ueda, Won-Hun Ham, Masaya Nakata, Seung Hoon Cheon, H. Fujioka, J.-M. Beau, M. Mizuno, J. A. Tino, L. D. Hawkins, Yoshito Kishi, M. J. Martinelli, W. J. Christ, M. Taniguchi, J. B. White, Haolun Jin, J. Uenishi, R. W. Armstrong, Arnold E. Stütz
Publikováno v: Journal of the American Chemical Society. 111:7525-7530
The total synthesis of a fully protected palytoxin carboxylic acid was achieved from eight building blocks. The C.22-C.23 and C.37-C.38 bonds were formed via Wittig olefination, followed by hydrogenation. The Ni(II)/Cr(II)-mediated coupling reaction
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80027d86579d1666dd3567ada102d285
https://doi.org/10.1021/ja00201a037
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10
A series of (2S)-2-O-protected-2-hydroxypropanals (L-lactaldehydes) suitable for use as optically active intermediates
Autor: Suhail K. Massad, L. D. Hawkins, David C. Baker
Publikováno v: The Journal of Organic Chemistry. 48:5180-5182
Preparation de (t-butyl dimethyl siloxy)-2, (t-butyl diphenyl siloxy)-2, (methoxy-2' ethoxymethoxy)-2 propanals. Determination de la purete optique du L-lactate de methyle par spectrometrie RMN 1 H
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac0fac09a1981ee3abb2beb1d4033ae3
https://doi.org/10.1021/jo00174a006
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