Zobrazeno 1 - 10
of 44
pro vyhledávání: '"L. D. Bowers"'
Autor:
L. D. Bowers, Pui-Yuen Wong, T. G. Rosano, I. J. Mcgilveray, David Freeman, P. A. Keown, R. W. Yatscoff, J. R. Jeffery, Leslie M. Shaw
Publikováno v:
Clinical Chemistry. 36:1841-1846
The Bureau of Drug Research, Health Protection Branch I the Government of Canada, requested of the transplant nd clinical chemistry professional groups that a consensus leeting be held, to develop a “state-of-the-art” consensus aper on cyclosporu
Autor:
R S, Black, L D, Bowers
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 146
Autor:
D J, Borts, L D, Bowers
Publikováno v:
Journal of mass spectrometry : JMS. 35(1)
Measurement of the ratio of testosterone (T) and epitestosterone (E) in urine has been used as an indication of 'natural' steroid supplementation for a decade. The direct measurement of the glucuronide and sulfate conjugates of testosterone and epite
Autor:
L D, Bowers
Publikováno v:
Clinical chemistry. 45(2)
Autor:
L D, Bowers
Publikováno v:
Clinical chemistry. 44(2)
The practice of therapeutic drug monitoring is based on several disciplines, including pharmacokinetics, pharmacodynamics, and chemical analysis. The impact of the analysis on the determination of pharmacokinetic parameters is not well appreciated. A
Autor:
C, Liu, L D, Bowers
Publikováno v:
Clinical chemistry. 43(7)
We describe the use of an HPLC/MS technique for the characterization of nicked fragments of hCG beta-subunit. After reductive alkylation of the nicked hCG beta-subunit with vinylpyridine, endoproteinase Glu-C or trypsin was used to digest the protein
Autor:
L D, Bowers
Publikováno v:
Clinical chemistry. 43(7)
The use and abuse of performance-enhancing substances has been an issue in sports since the ancient Greeks. The availability of numerous synthetic steroids and recombinant peptide hormones has made testing an analytical challenge. Recent advances in
Autor:
L D, Bowers, D J, Borts
Publikováno v:
Clinical chemistry. 43(6 Pt 1)
Limits of detection are important issues for GC/MS screening for anabolic agents and for confirmation of various drugs of abuse. We compared a quadrupole ion trap (QIT) operated in two different selected-ion storage modes and a quadrupole mass filter
Autor:
C, Liu, L D, Bowers
Publikováno v:
Journal of mass spectrometry : JMS. 32(1)
A high-performance liquid chromatographic/electrospray mass spectrometric (HPLC/MS) technique is described for the characterization of the beta-subunit of the glycopeptide human chorionic gonadotropin (hCG). The beta-subunit of hCG was dissociated fr
Publikováno v:
Clinical transplantation. 9(1)
Despite the critical role of the liver in the metabolism of cyclosporine, only a few studies have measured hepatic levels (CSAH) in patients receiving the drug, and none has directly assayed hepatic levels of the metabolites. In this study we measure