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Akademický článek

Effects of ENSO events on the intensity, seasonality, and diversity of reproductive phenology of Miconia (Melastomataceae) species in tropical rainforest

Autor: A. G. Barros, J. S. Costa, M. R. O. Lima, I. P. Souza, L. A. P. Miranda, A. P. L. Couto-Santos, L. S. Funch

Publikováno v: Brazilian Journal of Biology, Vol 83 (2023)

Abstract We evaluated the phenology and reproductive phenological diversity of three sympatric species of Miconia in a gallery forest in the Chapada Diamantina mountains, Bahia, Brazil. The reproductive phenophases (bud, flower, immature fruit, and m

Externí odkaz: https://doaj.org/article/2d71e3dc117e46039fd6416296969c1a

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Akademický článek

Potential role of vacuum-assisted procedures in resecting breast cancers and highlighting selection criteria to support future trials

Autor: C. N. Valadares, H. L. Couto, A. N. Soares, P. H. Toppa, B. P. Ricardo, S. A. McIntosh, N. Sharma, V. Resende

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

PurposeThe purpose of this study was to evaluate the role of vacuum-assisted biopsy (VAB) in resecting breast cancers.MethodsRetrospective database analysis of 116 cancers [both invasive breast cancers (IC) and ductal carcinoma in situ (DCIS)] diagno

Externí odkaz: https://doaj.org/article/79c01b968ad3410580430186f08e0673

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Akademický článek

Insights into the Lysine Acetylome of the Haloarchaeon Haloferax volcanii during Oxidative Stress by Quantitative SILAC-Based Proteomics

Autor: Ricardo L. Couto-Rodríguez, Jin Koh, Sixue Chen, Julie A. Maupin-Furlow

Publikováno v: Antioxidants, Vol 12, Iss 6, p 1203 (2023)

Oxidative stress adaptation strategies are important to cell function and are linked to cardiac, neurodegenerative disease, and cancer. Representatives of the Archaea domain are used as model organisms based on their extreme tolerance to oxidants and

Externí odkaz: https://doaj.org/article/013a4c10fa1c40b1a9393363756b6da5

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Akademický článek

TrmB Family Transcription Factor as a Thiol-Based Regulator of Oxidative Stress Response

Autor: Paula Mondragon, Sungmin Hwang, Lakshmi Kasirajan, Rebecca Oyetoro, Angelina Nasthas, Emily Winters, Ricardo L. Couto-Rodriguez, Amy Schmid, Julie A. Maupin-Furlow

Publikováno v: mBio, Vol 13, Iss 4 (2022)

ABSTRACT Oxidative stress causes cellular damage, including DNA mutations, protein dysfunction, and loss of membrane integrity. Here, we discovered that a TrmB (transcription regulator of mal operon) family protein (Pfam PF01978) composed of a single

Externí odkaz: https://doaj.org/article/1b774026c613423b913c5773f40cbcbe

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Akademický článek

RUNX1 Is Regulated by Androgen Receptor to Promote Cancer Stem Markers and Chemotherapy Resistance in Triple Negative Breast Cancer

Autor: Natalia B. Fernández, Sofía M. Sosa, Justin T. Roberts, María S. Recouvreux, Luciana Rocha-Viegas, Jessica L. Christenson, Nicole S. Spoelstra, Facundo L. Couto, Ana R. Raimondi, Jennifer K. Richer, Natalia Rubinstein

Publikováno v: Cells, Vol 12, Iss 3, p 444 (2023)

Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype for which no effective targeted therapies are available. Growing evidence suggests that chemotherapy-resistant cancer cells with stem-like properties (CSC) may repopulate the

Externí odkaz: https://doaj.org/article/82ee5a10864e493fb5f423a04c49e88e

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Akademický článek

Ultrasound-mediated radical cascade reactions: Fast synthesis of functionalized indolines from 2-(((N-aryl)amino)methyl)acrylates

Autor: Milene M. Hornink, Vinicius R. Nascimento, Julia L. Couto, Caroline S. Santos, Leandro H. Andrade

Publikováno v: Ultrasonics Sonochemistry, Vol 79, Iss , Pp 105778- (2021)

Novel functionalized indolines were synthesized from 2-(((N-aryl)amino)methyl)acrylates and formamides under ultrasonic irradiation for the first time. Aiming to develop a straightforward and easy-to-implement methodology for the synthesis of indolin

Externí odkaz: https://doaj.org/article/0a4a267930184fde8ca4d443d73a4310

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Akademický článek

Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons

Autor: Isadora C. Furigo, Pryscila D. S. Teixeira, Gabriel O. de Souza, Gisele C. L. Couto, Guadalupe García Romero, Mario Perelló, Renata Frazão, Lucila L. Elias, Martin Metzger, Edward O. List, John J. Kopchick, J. Donato

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Reduction in food intake elicits neuroendocrine adaptations to counterregulate the negative energy balance, e.g. via reduction in leptin levels. Here, the authors identify an additional starvation signal, growth hormone (GH). Blocking GH receptor att

Externí odkaz: https://doaj.org/article/d4067e42ca514c9c9b243f9101c626a6

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Akademický článek

Bacterial‐like nitric oxide synthase in the haloalkaliphilic archaeon Natronomonas pharaonis

Autor: Silvia S. Orsini, Kimberly L. James, Destiny J. Reyes, Ricardo L. Couto‐Rodriguez, Miriam K. Gulko, Angela Witte, Ronan K. Carroll, Kelly C. Rice

Publikováno v: MicrobiologyOpen, Vol 9, Iss 11, Pp n/a-n/a (2020)

Abstract Bacterial nitric oxide (NO) synthases (bNOS) play diverse and important roles in microbial physiology, stress resistance, and virulence. Although bacterial and mammalian NOS enzymes have been well‐characterized, comparatively little is kno

Externí odkaz: https://doaj.org/article/658c504dd34f439c921acb47f42e2dd7

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