Recruitment of α4β7 monocytes and neutrophils to the brain in experimental colitis is associated with elevated cytokines and anxiety-like behavior

Autor: Nina L. Cluny, Kewir D. Nyuyki, Wagdi Almishri, Lateece Griffin, Benjamin H. Lee, Simon A. Hirota, Quentin J. Pittman, Mark G. Swain, Keith A. Sharkey

Publikováno v: Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)

Abstract Background Behavioral comorbidities, such as anxiety and depression, are a prominent feature of IBD. The signals from the inflamed gut that cause changes in the brain leading to these behavioral comorbidities remain to be fully elucidated. W

Externí odkaz: https://doaj.org/article/ef43bce9d5ca482a970897fdee876d16

Colitis-Induced Microbial Perturbation Promotes Postinflammatory Visceral Hypersensitivity

Autor: Nicolas Esquerre, Dominique Bihan, Alana Schick, Yasmin Nasser, Manon Defaye, Fernando A. Vicentini, Lilian Basso, Keith A. Sharkey, Christophe Altier, Simon A. Hirota, Ian A. Lewis, Nina L. Cluny, Humberto Jijon, Markus B. Geuking

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 225-244 (2020)

Background & Aims Despite achieving endoscopic remission, more than 20% of inflammatory bowel disease patients experience chronic abdominal pain. These patients have increased rectal transient receptor potential vanilloid-1 receptor (TRPV1) expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1dcda8afaf3b78c0b7073da88d285f
http://europepmc.org/articles/PMC7301239

Leukocyte - Cerebral Endothelial Cell Interactions in the Brain Lead to Anxiety-like Behaviour in Experimental Colitis

Autor: Nina L. Cluny, Kewir D. Nyuyki, Wagdi Almishri, Lateece Griffin, Benjamin H. Lee, Simon A. Hirota, Quentin J. Pittman, Mark G. Swain, Keith A. Sharkey

BACKGROUNDBehavioral comorbidities, such as anxiety and depression, are a prominent feature of IBD. The signals from the inflamed gut that cause changes in the brain leading to these behavioral comorbidities remain to be fully elucidated. We tested t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc83bb8dbe2d8a6c745b210236546ee8
https://doi.org/10.21203/rs.3.rs-1132827/v1

Brain TNF drives post-inflammation depression-like behavior and persistent pain in experimental arthritis

Autor: Mark G. Swain, William Antonio Gonçalves, Derek M. McKay, Wagdi Almishri, Lateece Griffin, Keith A. Sharkey, Simon A. Hirota, Alexander J. Mathews, Nina L. Cluny, Benjamin H. Lee, Fernando Lopes, Vanessa Pinho, Fernando A. Vicentini, Quentin J. Pittman

Publikováno v: Brain, behavior, and immunity. 89

Patients with rheumatoid arthritis experience chronic pain, depression and fatigue, even when inflammation of the joints is well controlled. To study the relationship between arthritis, depression, and sustained pain when articular inflammation is no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32bc14d47426526409b803e8300204fa
https://pubmed.ncbi.nlm.nih.gov/32592863

A52 ANTIBIOTICS WORSEN VISCERAL BUT NOT SOMATIC HYPERALGESIA IN A MOUSE MODEL OF POST-INFLAMMATORY EXPERIMENTAL COLITIS

Autor: N Esquerre, L Basso, F Vicentini, N L Cluny, I Lewis, K A Sharkey, C Altier, Y Nasser

BACKGROUND: Over 20% of inflammatory bowel disease (IBD) patients in endoscopic remission experience chronic abdominal pain. Studies also show widespread somatic pain in the absence of inflammation, suggesting altered central pain neurotransmission.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8808440e400d1a40fd9f5eddc1664a
https://europepmc.org/articles/PMC6512509/