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Publikováno v:
Regulatory toxicology and pharmacology : RTP. 137
In silico models are often built solely on publicly available data which may mean that they are less predictive for proprietary chemical space. Data sharing initiatives can improve the performance of such models, but organisations are often unable to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475a7292e4817cc2e56798489bbbbb61
https://pubmed.ncbi.nlm.nih.gov/36400282
https://pubmed.ncbi.nlm.nih.gov/36400282
Publikováno v:
Computational Toxicology. 27:100275
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b315b6f1de2759b9040a59f6909bbbba
https://doi.org/10.1016/j.comtox.2023.100275
https://doi.org/10.1016/j.comtox.2023.100275
Autor:
Amy L. Chilton
Publikováno v:
Baptist Quarterly. 52:158-171
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdf3590373ece309dae354e0b5d66b48
https://doi.org/10.1080/0005576x.2021.1947650
https://doi.org/10.1080/0005576x.2021.1947650
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 135
In June 2021 the Organisation for Economic Co-operation and Development published Guideline No. 497 on Defined Approaches for Skin Sensitisation (DASS GL). There are two DAs published, known as the 2o3 and the ITS. The 2o3 uses two concordant results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf2bf8dee2765d63d249b8b342279ac
https://pubmed.ncbi.nlm.nih.gov/36007801
https://pubmed.ncbi.nlm.nih.gov/36007801
Autor:
Robert Foster, Adrian Fowkes, Barber Christopher Gordon, Susanne A. Stalford, Emma Hill, Alex Cayley, Artur Polit, Martyn L. Chilton, Jonathan D. Vessey, Crina Heghes, Donna S. Macmillan, Steven Kane, Alun Myden, Natasha T. Hill, Daniel A. Newman, Thomas Ball
Publikováno v:
Toxicology Research
Adverse outcome pathways have shown themselves to be useful ways of understanding and expressing knowledge about sequences of events that lead to adverse outcomes (AOs) such as toxicity. In this paper we use the building blocks of adverse outcome pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5707efe23f37bec13dfed018a387218a
https://doi.org/10.1093/toxres/tfaa099
https://doi.org/10.1093/toxres/tfaa099
Autor:
Jessica C. Graham, Alejandra Trejo-Martin, Martyn L. Chilton, Jakub Kostal, Joel Bercu, Gregory L. Beutner, Uma S. Bruen, David G. Dolan, Stephen Gomez, Jedd Hillegass, John Nicolette, Matthew Schmitz
Publikováno v:
Chemical research in toxicology. 35(6)
Peptide couplers (also known as amide bond-forming reagents or coupling reagents) are broadly used in organic chemical syntheses, especially in the pharmaceutical industry. Yet, occupational health hazards associated with this chemical class are larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ea18af40f3631f3592327aa4d47482
https://pubmed.ncbi.nlm.nih.gov/35532537
https://pubmed.ncbi.nlm.nih.gov/35532537
Autor:
Martyn L. Chilton, Anne Marie Api, Robert S. Foster, G. Frank Gerberick, Maura Lavelle, Donna S. Macmillan, Mihwa Na, Devin O'Brien, Catherine O'Leary-Steele, Mukesh Patel, David J. Ponting, David W. Roberts, Robert J. Safford, Rachael E. Tennant
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 133
The Dermal Sensitisation Thresholds (DST) are Thresholds of Toxicological Concern, which can be used to justify exposure-based waiving when conducting a skin sensitisation risk assessment. This study aimed to update the published DST values by expand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d750de7d1a7ff504f5fa7748836ba6e3
https://pubmed.ncbi.nlm.nih.gov/35662638
https://pubmed.ncbi.nlm.nih.gov/35662638
Publikováno v:
The American Journal of Occupational Therapy. 76:7610505107p1-7610505107p1
Date Presented 04/02/2022 Very little research exists examining how specific education about older adult sexual health and sexual activity may improve OT practitioners’ knowledge of and attitudes toward geriatric sexuality and application to clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d398317e83c0ce857941b7864564f2e
https://doi.org/10.5014/ajot.2022.76s1-po107
https://doi.org/10.5014/ajot.2022.76s1-po107
Autor:
Warrick L Chilton, Francine Z Marques, Jenny West, George Kannourakis, Stuart P Berzins, Brendan J O'Brien, Fadi J Charchar
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e92088 (2014)
Telomeres are specialized nucleoprotein structures that protect chromosomal ends from degradation. These structures progressively shorten during cellular division and can signal replicative senescence below a critical length. Telomere length is predo
Externí odkaz:
https://doaj.org/article/fe88e93af99a4fe6bec4b81df591300d