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Modeling by disruption and a selected‐for partner for the nude locus

Autor: Anne M Whalen, Jian Li, Wenyu Fu, Lorin Weiner, Mario Clemente Estable, Laurel A. Raftery, Yun-Kyoung Lee, Janice L. Brissette, Kristin White

Publikováno v: EMBO Reports
EMBO Rep

A long‐standing problem in biology is how to dissect traits for which no tractable model exists. Here, we screen for genes like the nude locus (Foxn1)—genes central to mammalian hair and thymus development—using animals that never evolved hair,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376090632e19f08a40329361ca108d31
http://europepmc.org/articles/PMC7926259

A composite enhancer regulates p63 gene expression in epidermal morphogenesis and in keratinocyte differentiation by multiple mechanisms

Autor: Edith Aberdam, Janice L. Brissette, Sharmila Fagoonee, Dario Antonini, Fiorella Altruda, Daniel Aberdam, Anna Sirico, Raffaele Ambrosio, Caterina Missero, Carmen Campanile

Publikováno v: Nucleic acids research (Online) 43 (2015): 862–874. doi:10.1093/nar/gku1396
info:cnr-pdr/source/autori:Antonini, Dario; Sirico, Anna; Aberdam, Edith; Ambrosio, Raffaele; Campanile, Carmen; Fagoonee, Sharmila; Altruda, Fiorella; Aberdam, Daniel; Brissette, Janice L; Missero, Caterina/titolo:A composite enhancer regulates p63 gene expression in epidermal morphogenesis and in keratinocyte differentiation by multiple mechanisms./doi:10.1093%2Fnar%2Fgku1396/rivista:Nucleic acids research (Online)/anno:2015/pagina_da:862/pagina_a:874/intervallo_pagine:862–874/volume:43
Nucleic Acids Research

p63 is a crucial regulator of epidermal development, but its transcriptional control has remained elusive. Here, we report the identification of a long-range enhancer (p63LRE) that is composed of two evolutionary conserved modules (C38 and C40), acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa67679e32937a2762ca67e268703c1
https://doi.org/10.1093/nar/gku1396

A pair of transmembrane receptors essential for the retention and pigmentation of hair

Autor: Lorin Weiner, Lionel Larue, Janice L. Brissette, Hideyuki Beppu, Katia Georgopoulos, En Li, Yun-Kyoung Lee, Rong Han

Publikováno v: genesis. 50:783-800

Hair follicles are simple, accessible models for many developmental processes. Here, using mutant mice, we show that Bmpr2, a known receptor for bone morphogenetic proteins (Bmps), and Acvr2a, a known receptor for Bmps and activins, are individually

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d936c92779dce1fd448ec6cebefb07
https://doi.org/10.1002/dvg.22039

Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes

Autor: Ruzanna Atoyan, Tatyana Y. Sharova, Lorin Weiner, Vladimir A. Botchkarev, Andrey A. Sharov, Alice Tommasi di Vignano, G. Paolo Dotto, Andrei N. Mardaryev, Shi Yang, Janice L. Brissette

Publikováno v: Proceedings of the National Academy of Sciences. 103:18166-18171

Bone morphogenetic protein (BMP) signaling is involved in the regulation of a large variety of developmental programs, including those controlling organ sizes. Here, we show that transgenic (TG) mice overexpressing the BMP antagonist noggin (promoter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38306dbeaa3c18d50276f235644e1fc1
https://doi.org/10.1073/pnas.0608899103