Zobrazeno 1 - 10
of 480
pro vyhledávání: '"L. Bogorad"'
Autor:
Lidia Avalle, Francesca Marino, Annalisa Camporeale, Chiara Guglielmi, Daniele Viavattene, Silvio Bandini, Laura Conti, James Cimino, Marco Forni, Cristina Zanini, Alessandra Ghigo, Roman L. Bogorad, Federica Cavallo, Paolo Provero, Victor Koteliansky, Valeria Poli
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 62-72 (2020)
Myocarditis can lead to autoimmune disease, dilated cardiomyopathy, and heart failure, which is modeled in the mouse by cardiac myosin immunization (experimental autoimmune myocarditis [EAM]). Signal transducer and activator of transcription 3 (STAT3
Externí odkaz:
https://doaj.org/article/c6c3628a9cb8444685166b33699a3952
Autor:
Hernán Morales-Navarrete, Hidenori Nonaka, André Scholich, Fabián Segovia-Miranda, Walter de Back, Kirstin Meyer, Roman L Bogorad, Victor Koteliansky, Lutz Brusch, Yannis Kalaidzidis, Frank Jülicher, Benjamin M Friedrich, Marino Zerial
Publikováno v:
eLife, Vol 8 (2019)
Functional tissue architecture originates by self-assembly of distinct cell types, following tissue-specific rules of cell-cell interactions. In the liver, a structural model of the lobule was pioneered by Elias in 1949. This model, however, is in co
Externí odkaz:
https://doaj.org/article/33e29e9f287b4b73becdf7cfdc1d6f67
Autor:
Anja Zeigerer, Roman L. Bogorad, Kirti Sharma, Jerome Gilleron, Sarah Seifert, Susanne Sales, Nikolaus Berndt, Sascha Bulik, Giovanni Marsico, Rochelle C.J. D’Souza, Naharajan Lakshmanaperumal, Kesavan Meganathan, Karthick Natarajan, Agapios Sachinidis, Andreas Dahl, Hermann-Georg Holzhütter, Andrej Shevchenko, Matthias Mann, Victor Koteliansky, Marino Zerial
Publikováno v:
Cell Reports, Vol 11, Iss 6, Pp 884-892 (2015)
The liver maintains glucose and lipid homeostasis by adapting its metabolic activity to the energy needs of the organism. Communication between hepatocytes and extracellular environment via endocytosis is key to such homeostasis. Here, we addressed t
Externí odkaz:
https://doaj.org/article/baacc26e5eff48688b9e18a1e0dc126a
Autor:
James Cimino, Silvio Bandini, Annalisa Camporeale, Alessandra Ghigo, Lidia Avalle, Roman L. Bogorad, Paolo Provero, Laura Conti, Marco Forni, Cristina Zanini, Chiara Guglielmi, Valeria Poli, Daniele Viavattene, Federica Cavallo, Victor Koteliansky, Francesca Marino
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 62-72 (2020)
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 62-72 (2020)
Myocarditis can lead to autoimmune disease, dilated cardiomyopathy, and heart failure, which is modeled in the mouse by cardiac myosin immunization (experimental autoimmune myocarditis [EAM]). Signal transducer and activator of transcription 3 (STAT3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ece6a75934d9e0add208822c762a6f
https://doi.org/10.1016/j.omtm.2020.05.023
https://doi.org/10.1016/j.omtm.2020.05.023
Autor:
Patrick B F O'Connor, Victor Koteliansky, Robert Langer, Timofei S. Zatsepin, Pavel V. Baranov, Daniel G. Anderson, Maxim V. Gerashchenko, Kevin J. Kauffman, Vadim N. Gladyshev, Anna S. Fefilova, Charles A. Whittaker, Elena M. Smekalova, Roman L. Bogorad
Publikováno v:
Elsevier
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
© 2019 Translation is an essential biological process, and dysregulation is associated with a range of diseases including ribosomopathies, diabetes, and cancer. Here, we examine translation dysregulation in vivo using RNAi to knock down the m-subuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3707e1b6cc7fc1075d06f75056c18207
https://doi.org/10.1016/j.omtn.2019.11.009
https://doi.org/10.1016/j.omtn.2019.11.009
Autor:
Vera M Ruda, Rohit Chandwani, Alfica Sehgal, Roman L Bogorad, Akin Akinc, Klaus Charisse, Alexander Tarakhovsky, Tatiana I Novobrantseva, Victor Koteliansky
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101749 (2014)
Argonaute 2 (Ago2) is the only mammalian Ago protein capable of mRNA cleavage. It has been reported that the activity of the short interfering RNA targeting coding sequence (CDS), but not 3' untranslated region (3'UTR) of an mRNA, is solely dependent
Externí odkaz:
https://doaj.org/article/944eb249cdc14faba263d18f526c0dbb
Autor:
Molly Plovanich, Roman L Bogorad, Yasemin Sancak, Kimberli J Kamer, Laura Strittmatter, Andrew A Li, Hany S Girgis, Satya Kuchimanchi, Jack De Groot, Lauren Speciner, Nathan Taneja, Jonathan Oshea, Victor Koteliansky, Vamsi K Mootha
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55785 (2013)
Mitochondrial calcium uptake is present in nearly all vertebrate tissues and is believed to be critical in shaping calcium signaling, regulating ATP synthesis and controlling cell death. Calcium uptake occurs through a channel called the uniporter th
Externí odkaz:
https://doaj.org/article/a7337a4d9d914019b479cff21e32b7e5
Autor:
Sergey E. Dmitriev, Vadim N. Gladyshev, Maxim V. Gerashchenko, Mikhail V. Nesterchuk, Timofei S. Zatsepin, Victor Koteliansky, Elena M. Smekalova, Joao A. Paulo, Piotr S. Kowalski, Daniel G. Anderson, Roman L. Bogorad, Kseniya A. Akulich, Steven P. Gygi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Due to breakthroughs in RNAi and genome editing methods in the past decade, it is now easier than ever to study fine details of protein synthesis in animal models. However, most of our understanding of translation comes from unicellular organisms and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c4fce07712951c093cc9f0ba048696
https://doi.org/10.1038/s41598-020-72399-4
https://doi.org/10.1038/s41598-020-72399-4
Autor:
Daniel G. Anderson, Charles A. Whittaker, Vikash P. Chauhan, Victor Koteliansky, Yulia Rybakova, John T. Gonzalez, Yize L. Dong, Roman L. Bogorad
Genomic studies have significantly improved our understanding of hepatocellular carcinoma (HCC) biology and have led to the discovery of multiple protein-coding genes driving hepatocarcinogenesis. In addition, these studies have identified thousands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::762c06ad3d85735c827105f929bb3faa
https://doi.org/10.1101/2020.07.01.181693
https://doi.org/10.1101/2020.07.01.181693
Autor:
Tatiana I Novobrantseva, Anna Borodovsky, Jamie Wong, Boris Klebanov, Mohammad Zafari, Kristina Yucius, William Querbes, Pei Ge, Vera M Ruda, Stuart Milstein, Lauren Speciner, Rick Duncan, Scott Barros, Genc Basha, Pieter Cullis, Akin Akinc, Jessica S Donahoe, K Narayanannair Jayaprakash, Muthusamy Jayaraman, Roman L Bogorad, Kevin Love, Katie Whitehead, Chris Levins, Muthiah Manoharan, Filip K Swirski, Ralph Weissleder, Robert Langer, Daniel G Anderson, Antonin de Fougerolles, Matthias Nahrendorf, Victor Koteliansky
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
Leukocytes are central regulators of inflammation and the target cells of therapies for key diseases, including autoimmune, cardiovascular, and malignant disorders. Efficient in vivo delivery of small interfering RNA (siRNA) to immune cells could thu
Externí odkaz:
https://doaj.org/article/31889f2554494de9a6c937025cd1946a