Nanofluidic qPCR unable to detect and serotype Streptococcus pneumoniae in urine samples of hospitalized South African patients with community-acquired pneumonia

Autor: Courtney P. Olwagen, Tariro R. Jeche, Lara Van Der Merwe, Marta C. Nunes, Shabir A. Madhi, Vicky L. Baillie

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-6 (2023)

Abstract Pneumonia is a major cause of death among adults living with HIV in South Africa, but the etiology of many cases remains unknown. This study evaluated the utility of a nanofluidic qPCR assay to detect and serotype Streptococcus pneumoniae in

Externí odkaz: https://doaj.org/article/41ddbe90c6734502b40db6189c61b11a

Factors predicting mortality in hospitalised HIV-negative children with lower-chest-wall indrawing pneumonia and implications for management.

Autor: Katherine E Gallagher, Juliet O Awori, Maria D Knoll, Julia Rhodes, Melissa M Higdon, Laura L Hammitt, Christine Prosperi, Henry C Baggett, W Abdullah Brooks, Nicholas Fancourt, Daniel R Feikin, Stephen R C Howie, Karen L Kotloff, Milagritos D Tapia, Orin S Levine, Shabir A Madhi, David R Murdoch, Katherine L O'Brien, Donald M Thea, Vicky L Baillie, Bernard E Ebruke, Alice Kamau, David P Moore, Lawrence Mwananyanda, Emmanuel O Olutunde, Phil Seidenberg, Samba O Sow, Somsak Thamthitiwat, J Anthony G Scott, PERCH Study Group

Publikováno v: PLoS ONE, Vol 19, Iss 3, p e0297159 (2024)

IntroductionIn 2012, the World Health Organization revised treatment guidelines for childhood pneumonia with lower chest wall indrawing (LCWI) but no 'danger signs', to recommend home-based treatment. We analysed data from children hospitalized with

Externí odkaz: https://doaj.org/article/826fb1c750b543528c052395d8cfd435

Clinical characteristics and histopathology of COVID-19 related deaths in South African adults.

Autor: Marta C Nunes, Martin J Hale, Sana Mahtab, Fikile C Mabena, Noluthando Dludlu, Vicky L Baillie, Bukiwe N Thwala, Toyah Els, Jeanine du Plessis, Marius Laubscher, Shakeel Mckenzie, Sihle Mtshali, Colin Menezes, Natali Serafin, Sarah van Blydenstein, Merika Tsitsi, Brian Dulisse, Shabir A Madhi

Publikováno v: PLoS ONE, Vol 17, Iss 1, p e0262179 (2022)

Comparisons of histopathological features and microbiological findings between decedents with respiratory symptoms due to SARS-CoV-2 infection or other causes, in settings with high prevalence of HIV and Mycobacterium tuberculosis (MTB) infections ha

Externí odkaz: https://doaj.org/article/c68e0d70e3724e2db5a72e5dd99941b1

Mesophyll porosity is modulated by the presence of functional stomata

Autor: Marjorie R. Lundgren, Andrew Mathers, Alice L. Baillie, Jessica Dunn, Matthew J. Wilson, Lee Hunt, Radoslaw Pajor, Marc Fradera-Soler, Stephen Rolfe, Colin P. Osborne, Craig J. Sturrock, Julie E. Gray, Sacha J. Mooney, Andrew J. Fleming

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)

Gas exchange for photosynthesis occurs via stomata on the leaf surface and the airspace in the underlying mesophyll tissue. Here, the authors show that stomatal function modulates mesophyll airspace formation and that their coordinated development in

Externí odkaz: https://doaj.org/article/569b851c35a849ea9b0e515f862ac06e

Global burden of acute lower respiratory infection associated with human metapneumovirus in children under 5 years in 2018: a systematic review and modelling study

Autor: Xin Wang, PhD, You Li, PhD, Maria Deloria-Knoll, PhD, Shabir A Madhi, ProfPhD, Cheryl Cohen, MD, Asad Ali, MD, Sudha Basnet, ProfMD, Quique Bassat, ProfMD, W Abdullah Brooks, MD, Malinee Chittaganpitch, MSc, Marcela Echavarria, PhD, Rodrigo A Fasce, BSc, Doli Goswami, MSc, Siddhivinayak Hirve, PhD, Nusrat Homaira, PhD, Stephen R C Howie, PhD, Karen L Kotloff, ProfMD, Najwa Khuri-Bulos, ProfMD, Anand Krishnan, ProfMD, Marilla G Lucero, MD, Socorro Lupisan, MD, Ainara Mira-Iglesias, MSc, David P Moore, PhD, Cinta Moraleda, PhD, Marta Nunes, PhD, Histoshi Oshitani, ProfMD, Betty E Owor, PhD, Fernando P Polack, ProfMD, Katherine L O'Brien, ProfMD, Zeba A Rasmussen, MD, Barbara A Rath, ProfMD, Vahid Salimi, PhD, J Anthony G Scott, ProfFRCP, Eric A F Simões, ProfMD, Tor A Strand, ProfPhD, Donald M Thea, ProfMD, Florette K Treurnicht, PhD, Linda C Vaccari, MbChB, Lay-Myint Yoshida, ProfPhD, Heather J Zar, ProfPhD, Harry Campbell, ProfMD, Harish Nair, ProfPhD, Romina Libster, Grieven Otieno, Imane Joundi, Shobha Broor, Mark Nicol, Ritvik Amarchand, Ting Shi, F. Xavier López-Labrador, Julia M. Baker, Alexandra Jamison, Avinash Choudekar, Sanjay Juvekar, Patrick Obermeier, Brunhilde Schweiger, Lola Madrid, Elizabeth Thomas, Miguel Lanaspa, Hanna Nohynek, James Nokes, Marta Werner, Anh Danhg, Mandeep Chadha, Joan Puig-Barberà, Mauricio T. Caballero, Maria Mathisen, Sibongile Walaza, Orienka Hellferscee, Matt Laubscher, Melissa M. Higdon, Meredith Haddix, Pongpun Sawatwong, Henry C. Baggett, Phil Seidenberg, Lawrence Mwanayanda, Martin Antonio, Bernard E. Ebruke, Tanja Adams, Mustafizur Rahman, Mohammed Ziaur Rahman, Samboa O. Sow, Vicky L. Baillie, Lesley Workman, Michiko Toizumi, Milagritos D. Tapia, Thi hien anh Nguyen, Susan Morpeth

Publikováno v: The Lancet Global Health, Vol 9, Iss 1, Pp e33-e43 (2021)

Summary: Background: Human metapneumovirus is a common virus associated with acute lower respiratory infections (ALRIs) in children. No global burden estimates are available for ALRIs associated with human metapneumovirus in children, and no licensed

Externí odkaz: https://doaj.org/article/4527be1f507e45a8aef2522ddddee038