Zobrazeno 1 - 2
of 2
pro vyhledávání: '"L. B. Zeiger"'
Autor:
K. A. Pickering, K. Gilroy, J. W. Cassidy, S. K. Fey, A. K. Najumudeen, L. B. Zeiger, D. F. Vincent, D. M. Gay, J. Johansson, R. P. Fordham, B. Miller, W. Clark, A. Hedley, E. B. Unal, C. Kiel, E. McGhee, L. M. Machesky, C. Nixon, A. E. Johnsson, M. Bain, D. Strathdee, S. R. van Hoof, J. P. Medema, K. I. Anderson, S. M. Brachmann, V. M. Stucke, A. Malliri, M. Drysdale, M. Turner, L. Serrano, K. Myant, A. D. Campbell, O. J. Sansom
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Loss of small GTPase RAC1 suppresses intestinal tumorigenesis caused by APC loss, but impacts normal intestinal homeostasis. Here, the authors provide an alternative method of reducing RAC1 activity by the combined targeting of three RAC-GEFs and sho
Externí odkaz:
https://doaj.org/article/93c813a5931245bf853878d1057ebcd6
Autor:
D. J. Huels, L. Bruens, M. C. Hodder, P. Cammareri, A. D. Campbell, R. A. Ridgway, D. M. Gay, M. Solar-Abboud, W. J. Faller, C. Nixon, L. B. Zeiger, M. E. McLaughlin, E. Morrissey, D. J. Winton, H. J. Snippert, J. van Rheenen, O. J. Sansom
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Wnt ligands are essential for intestinal homoeostasis and stem cell maintenance. Here, the authors show that reduction in Wnt secretion reduces the number of intestinal stem cells; this results in rapid fixation of mutated stem cells and accelerated
Externí odkaz:
https://doaj.org/article/1a2839335a8e4193bb5d85dedd7c98ab