Výsledky vyhledávání - "L. B. CIESLINSKI"

Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+T-Lymphocytes

Autor: Andrew G. Nicholson, Susan J. Smith, Louise E. Donnelly, Peter Fenwick, Robert Newton, Mark A. Giembycz, Mary S. Barnette, Peter J. Barnes, L. B. Cieslinski

Publikováno v: Molecular Pharmacology. 66:1679-1689

The biochemical and pharmacological characteristics in human proinflammatory cells of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a novel and selective inhibitor of phosphodiesterase (PDE) 7, are described. BRL 50481 inhibited the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::289242c44d2fd352fe9d0d54a7489afa
https://doi.org/10.1124/mol.104.002246

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Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B

Autor: Miriam Burman, M Grous, Mary S. Barnette, Carol D. Manning, David M Essayan, Siegfried B. Christensen, L. B. Cieslinski, Theodore J. Torphy

Publikováno v: British Journal of Pharmacology. 128:1393-1398

1. Of the four major phosphodiesterase 4 (PDE4) subtypes, PDE4A, PDE4B and PDE4D are widely expressed in human inflammatory cells, including monocytes and T lymphocytes. We explored the functional role of these subtypes using ten subtype-selective PD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51a6d705c94ad234a80956c8fada41a2
https://doi.org/10.1038/sj.bjp.0702911

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Association of the anti-inflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [3H]rolipram binding

Autor: Rush Ja, Esser Km, L. B. Cieslinski, M S Barnette, T J Torphy, Burman M, Siegfried B. Christensen, Prabhakar Us, Bartus Jo

Publikováno v: Biochemical Pharmacology. 51:949-956

Phosphodiesterase 4 (PDE4) inhibitors are novel anti-inflammatory compounds. Unfortunately, the archetypal PDE4 inhibitor rolipram produces central nervous system and gastrointestinal side-effects. To exploit these agents, we need to identify PDE4 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2dd37212797c4643cdca190be92a344
https://doi.org/10.1016/0006-2952(96)00053-6

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Characterization of two human cAMP-specific phosphodiesterase subtypes expressed in baculovirus-infected insect cells

Autor: Charles R. Hanning, Megan M. McLaughlin, George P. Livi, Bernard Y. Amegadzie, L. B. Cieslinski, Miriam Burman, Theodore J. Torphy

Publikováno v: Cell Biology International. 19:477-484

Recombinant baculoviruses were constructed to express cDNAs encoding two distinct subtypes of human cAMP-specific phosphodiesterase (hPDE4A and hPDE4B). Infection of Spodoptera frugiperda insect cells with the appropriate recombinant baculoviruses re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53ff31d3c29c1444a98f960967b8b18
https://doi.org/10.1006/cbir.1995.1091

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A Candida albicans cyclic nucleotide phosphodiesterase: cloning and expression in Saccharomyces cerevisiae and biochemical characterization of the recombinant enzyme

Autor: G. P. Livi, A. R. Shatzman, L B Cieslinski, Lois L. Hoyer, M. M. Mclaughlin, T J Torphy

Publikováno v: Microbiology. 140:1533-1542

We have cloned a Candida albicans gene, which encodes a cyclic nucleotide phosphodiesterase (PDEase), by complementation in a Saccharomyces cerevisiae PDEase-deficient mutant. The deduced amino acid sequence is similar to that of the low-affinity PDE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a1bc6a4426db2ce024961ab0b481c4
https://doi.org/10.1099/13500872-140-7-1533

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Crystal structure, absolute configuration, and phosphodiesterase inhibitory activity of (+)-1-(4-bromobenzyl)-4-[(3-cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone

Autor: Paul W. Baures, L. B. Cieslinski, Karl F. Erhard, Siegfried B. Christensen, Drake S. Eggleston, Theodore J. Torphy

Publikováno v: Journal of Medicinal Chemistry. 36:3274-3277

Chiral HPLC resolution of the phosphodiesterase IV (PDE IV) inhibitor rolipram (1) provided (-)-1, and this enantiomer was converted into its 1-(4-bromobenzyl) derivative, (+)-2. X-ray structural analysis of (+)-2 established the absolute configurati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b665fd5d4e98c7b97b77f997512ae52
https://doi.org/10.1021/jm00074a007

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A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA

Autor: M Burman, L B Cieslinski, George P. Livi, Megan M. McLaughlin, T J Torphy

Publikováno v: Journal of Biological Chemistry. 268:6470-6476

We have isolated cDNA clones from human frontal cortex cDNA libraries that encode a unique subtype of the low-Km, cAMP-specific phosphodiesterases (PDEs IV). The 564-amino acid sequence of the protein (human brain PDE IV (hPDE IVB)) shows significant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1530e105122a0f3d04c116f0d44a5f62
https://doi.org/10.1016/s0021-9258(18)53275-0

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Preliminary identification and role of phosphodiesterase isozymes in human basophils

Autor: P T Peachell, B J Undem, R P Schleimer, D W MacGlashan, L M Lichtenstein, L B Cieslinski, T J Torphy

Publikováno v: The Journal of Immunology. 148:2503-2510

We attempted to identify and establish the role of cyclic nucleotide phosphodiesterase (PDE) isozymes in human basophils by using standard biochemical techniques as well as describing the effects of isozyme-selective and nonselective inhibitors of PD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::633ba8a89d8d16cfd324e1fff2f41a2e
https://doi.org/10.4049/jimmunol.148.8.2503

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Cytokines modulate cilomilast response in lung fibroblasts

Autor: Mary S. Barnette, Fu Qiang Wen, Stephen I. Rennard, L. B. Cieslinski, Tadashi Kohyama, Tetsu Kobayashi, Shinji Abe, Qiuhong Fang, Xiangde Liu

Publikováno v: Clinical immunology (Orlando, Fla.). 111(3)

Fibroblasts, as a major source of extracellular interstitial connective tissue matrix, play an important role in wound healing and the development of fibrosis. The phosphodiesterase (PDE) 4 inhibitor cilomilast inhibits fibroblast chemotaxis and fibr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970aa6dbb3617253437caa28192d64c8
https://pubmed.ncbi.nlm.nih.gov/15183150

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Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B

Autor: C D, Manning, M, Burman, S B, Christensen, L B, Cieslinski, D M, Essayan, M, Grous, T J, Torphy, M S, Barnette

Publikováno v: British journal of pharmacology. 128(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c69566b42dceab27980c7f852f155e0
https://pubmed.ncbi.nlm.nih.gov/10602317

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