Zobrazeno 1 - 10
of 485
pro vyhledávání: '"L. Ayres"'
Autor:
Natalia Timofeeva, Mary L. Ayres, Natalia Baran, Janice M. Santiago-O’Farrill, Gamze Bildik, Zhen Lu, Marina Konopleva, Varsha Gandhi
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionChronic lymphocytic leukemia (CLL) cells are metabolically flexible and adapt to modern anticancer treatments. Bruton tyrosine kinase (BTK) and B-cell lymphoma-2 (BCL-2) inhibitors have been widely used to treat CLL, but CLL cells become
Externí odkaz:
https://doaj.org/article/5f4424f292934236ac1ccec24c8ba64a
Autor:
Burcu Aslan, Gorkem Kismali, Lakesla R. Iles, Ganiraju C. Manyam, Mary L. Ayres, Lisa S. Chen, Mihai Gagea, Maria Teresa Sabrina Bertilaccio, William G. Wierda, Varsha Gandhi
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 5, Pp 1-12 (2022)
Abstract Pirtobrutinib (LOXO-305), a reversible inhibitor of Bruton’s tyrosine kinase (BTK), was designed as an alternative strategy to treat ibrutinib-resistant disease that develops due to C481 kinase domain mutations. The clinical activity of pi
Externí odkaz:
https://doaj.org/article/8888c6f8f7de463288f684d22b1c67b9
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
B-cell receptor (BCR) signaling pathway and Bcl-2 family prosurvival proteins, specifically Bcl-2 and Mcl-1, are functional in the pathobiology of chronic lymphocytic leukemia (CLL). A pivotal and apical molecule in the BCR pathway is Bruton’s tyro
Externí odkaz:
https://doaj.org/article/c853ac29c27d400198f8b9fe0a08796c
Autor:
Jessica A. Goodheart, Sabrina Bleidißel, Dorothee Schillo, Ellen E. Strong, Daniel L. Ayres, Angelika Preisfeld, Allen G. Collins, Michael P. Cummings, Heike Wägele
Publikováno v:
Frontiers in Zoology, Vol 15, Iss 1, Pp 1-18 (2018)
Abstract Background A number of shelled and shell-less gastropods are known to use multiple defensive mechanisms, including internally generated or externally obtained biochemically active compounds and structures. Within Nudipleura, nudibranchs with
Externí odkaz:
https://doaj.org/article/a07df541ecfb4449a378bb265e9c4d27
Autor:
da Silva, Telma Erotides, Costa-Silva, Mariana, Correa, Carina G., Denardin, Giovana, Alencar, Maria L. Ayres, Coelho, Mara S. Pacheco Honório, Muraro-Wildner, Letícia, Luiza-Bazzo, Maria, González-Chica, David A., Dantas-Correa, Esther Buzaglo, Narciso-Schiavon, Janaína L., de Lucca Schiavon, Leonardo
Publikováno v:
In Annals of Hepatology March-April 2018 17(2):286-299
Autor:
Telma Erotides da Silva, Mariana Costa-Silva, Carina G. Correa, Giovana Denardin, Maria L. Ayres Alencar, Mara S. Pacheco Honório Coelho, Letícia Muraro-Wildner, Maria Luiza-Bazzo, David A. González-Chica, Esther Buzaglo Dantas-Correa, Janaína L. Narciso-Schiavon, Leonardo de Lucca Schiavon
Publikováno v:
Annals of Hepatology, Vol 17, Iss 2, Pp 286-299 (2018)
Introduction. Adiponectin and resistin levels are increased in patients with cirrhosis, but it prognostic significance is unknown. We sought to investigate the factors associated with adiponectin and resistin levels and its clinical significance in p
Externí odkaz:
https://doaj.org/article/2a19deaa459640acbae090c87ed2d7bd
Autor:
Hima V. Vangapandu, Mary L. Ayres, Christopher A. Bristow, William G. Wierda, Michael J. Keating, Kumudha Balakrishnan, Christine M. Stellrecht, Varsha Gandhi
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 10, Pp 762-771 (2017)
Peripheral blood chronic lymphocytic leukemia (CLL) cells are replicationally quiescent mature B-cells. In short-term cultures, supporting stromal cells provide a survival advantage to CLL cells by inducing transcription and translation without promo
Externí odkaz:
https://doaj.org/article/0f575792f8474370a5f9c493e6bd5062
Autor:
John V. Heymach, Varsha Gandhi, John D. Minna, Ferdinandos Skoulidis, Jing Wang, William G. Wierda, Monique Nilsson, Jayanthi Gudikote, Uma Giri, Jie Ding, Lixia Diao, Pan Tong, Youhong Fan, Mary L. Ayres, Ishita Akhter, Xiao Qu, Yu Qian, Chao Yang, Emrullah Yilmaz, Christine M. Stellrecht, Ana Galan-Cobo
Supplementary Data from Enhanced Vulnerability of LKB1-Deficient NSCLC to Disruption of ATP Pools and Redox Homeostasis by 8-Cl-Ado
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258bef6377c0c92b6a9aa53b41a98b39
https://doi.org/10.1158/1541-7786.22527521.v1
https://doi.org/10.1158/1541-7786.22527521.v1
Autor:
Varsha Gandhi, Christine M. Stellrecht, R. Eric Davis, Michael J. Keating, William G. Wierda, Kumudha Balakrishnan, Benny Abraham Kaipparettu, Mary L. Ayres, Ondrej Havranek, Hima V. Vangapandu
Peripheral blood chronic lymphocytic leukemia (CLL) cells are quiescent but have active transcription and translation processes, suggesting that these lymphocytes are metabolically active. Based on this premise, the metabolic phenotype of CLL lymphoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38046ccb772f97edfcbe3723f9b905be
https://doi.org/10.1158/1541-7786.c.6541188
https://doi.org/10.1158/1541-7786.c.6541188
Autor:
Varsha Gandhi, Christine M. Stellrecht, R. Eric Davis, Michael J. Keating, William G. Wierda, Kumudha Balakrishnan, Benny Abraham Kaipparettu, Mary L. Ayres, Ondrej Havranek, Hima V. Vangapandu
Supplemental Figure 1. Graphical representation of extracellular flux stress profiles from a CLL patient. Supplemental Figure 2. Sorting BCR knockout cells from Cas9 transfected JeKo-1 cells. Supplemental Figure 3. Sorting PIK3CD knockout cells from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90dfc1e26b1c8dcd303bc5df23531b01
https://doi.org/10.1158/1541-7786.22515804.v1
https://doi.org/10.1158/1541-7786.22515804.v1