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Marble Burying in NMRI Male Mice Is Preferentially Sensitive to Pre- Versus Postsynaptic 5-HT1A Receptor Biased Agonists

Autor: Laurent Bardin, Agnès L. Auclair, Liesbeth A. Bruins Slot, Adrian Newman-Tancredi, Ronan Depoortère

Publikováno v: Pharmacology. 106:114-118

Obsessive compulsive disorder (OCD) is a psychiatric disorder characterized by excessive and repetitive thoughts and gestures, mainly treated pharmacologically with selective serotonin reuptake inhibitors (SSRIs). The marble burying test in mice is c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f61fc1abc6e1525a5240d694a34aefef
https://doi.org/10.1159/000509729

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NLX-101, a highly selective 5-HT

Autor: R, Depoortère, A L, Auclair, A, Newman-Tancredi

Publikováno v: Behavioural brain research. 401

NLX-101 (also known as F15599) exhibits nanomolar affinity, exceptional selectivity and biased agonist activation of serotonin 5-HT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30c1bc7d28f09444115c04aca8d7e9ab
https://pubmed.ncbi.nlm.nih.gov/33358917

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Pharmacology profile of F17464, a dopamine D

Autor: Cristina, Cosi, Jean-Claude, Martel, Agnès L, Auclair, Ginetta, Collo, Laura, Cavalleri, Peter, Heusler, Ludovic, Leriche, Florence, Gaudoux, Pierre, Sokoloff, Paul C, Moser, Silvia, Gatti-McArthur

Publikováno v: European journal of pharmacology. 890

F17464 (N-(3-{4-[4-(8-Oxo-8H-[1,3]-dioxolo-[4,5-g]-chromen-7-yl)-butyl]-piperazin-1-yl}-phenyl)-methanesulfonamide, hydrochloride) is a new potential antipsychotic with a unique profile. The compound exhibits high affinity for the human dopamine rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b579498fc9f91e8cb99dd31e6d42ed6
https://pubmed.ncbi.nlm.nih.gov/33065094

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NLX-112, a highly selective 5-HT 1A receptor agonist, mediates analgesia and antidepressant-like activity in rats via spinal cord and prefrontal cortex 5-HT 1A receptors, respectively

Autor: Laurent Bardin, Mark A. Varney, Adrian Newman-Tancredi, Ronan Depoortère, Agnès L. Auclair, Francis Colpaert

Publikováno v: Brain Research. 1688:1-7

NLX-112 (a.k.a. F13640 or befiradol) possesses marked activity in a variety of animal models of pain and of neuropsychiatric disorders; it exhibits nanomolar affinity, exceptional selectivity and high agonist efficacy at 5-hydroxytryptamine1A (5–HT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e773d9670a44338ee6d398bf7b085574
https://doi.org/10.1016/j.brainres.2018.03.016

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NLX-101, a cortical 5-HT1A receptor biased agonist, reverses scopolamine-induced deficit in the delayed non-matching to position model of cognition

Autor: Adrian Newman-Tancredi, Ronan Depoortère, Agnès L. Auclair

Publikováno v: Brain Research. 1765:147493

NLX-101 is a selective, high efficacy, biased agonist at post-synaptic cortical 5-HT1A receptors. We have previously shown that it opposes deficits produced by blockade of NMDA receptors and has pro-cognitive activity of its own. Based on the strong

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::678fd9107e42029ad6f645c86ddb0806
https://doi.org/10.1016/j.brainres.2021.147493

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Akademický článek

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NLX-101, a highly selective 5-HT1A receptor biased agonist, mediates antidepressant-like activity in rats via prefrontal cortex 5-HT1A receptors

Autor: Ronan Depoortère, Agnès L. Auclair, Adrian Newman-Tancredi

Publikováno v: Behavioural Brain Research. 401:113082

NLX-101 (also known as F15599) exhibits nanomolar affinity, exceptional selectivity and biased agonist activation of serotonin 5-HT1A receptors. Given systemically, it displays antidepressant-like activity in the rat forced swim test (FST), and prefe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::efa5b6842291ff971c9fa6abd206a921
https://doi.org/10.1016/j.bbr.2020.113082

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Differences among conventional, atypical and novel putative D2/5-HT1A antipsychotics on catalepsy-associated behaviour in cynomolgus monkeys

Autor: Ronan Depoortère, Adrian Newman-Tancredi, Catherine Barret-Grévoz, Mark S. Kleven, Agnès L. Auclair, Martine Barreto

Publikováno v: Behavioural Brain Research. 203:288-295

Typical antipsychotics such as haloperidol exert their therapeutic effects via blockade of dopamine (DA) D 2 receptors, leading to extrapyramidal symptoms (EPS) in humans and catalepsy in rodents. In contrast, atypical antipsychotics and new generati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d60a2f3e157e41b1fb53c0b265d3c9
https://doi.org/10.1016/j.bbr.2009.05.015

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The five choice serial reaction time task: Comparison between Sprague–Dawley and Long–Evans rats on acquisition of task, and sensitivity to phencyclidine

Autor: Adrian Newman-Tancredi, Ronan Depoortère, Joël Besnard, Agnès L. Auclair

Publikováno v: Pharmacology Biochemistry and Behavior. 92:363-369

The 5-choice serial reaction time task (5-CSRTT) allows examination of multiple aspects of cognition/executive functions (attention/impulsivity/ perseveration). Most 5-CSRTT studies are performed with pigmented (i.e. Long-Evans: LE) rats; however, al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a0fdf6f2f9870293ffd13fe4b81bea
https://doi.org/10.1016/j.pbb.2009.01.005

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