Zobrazeno 1 - 10
of 389
pro vyhledávání: '"L. Aron"'
Publikováno v:
Cureus.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6b338d2d257a906831071275a991e88
https://doi.org/10.7759/cureus.28590
https://doi.org/10.7759/cureus.28590
BackgroundThe search for a single, pathogenic genetic variant in a patient suspected to have a monogenic inborn error of immunity (IEI) often reveals a multitude of rare variants of unknown significance (VUS). Distinguishing which VUS is disease-caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::117dedbf07d2e1ce4263b4e373391172
https://doi.org/10.1101/2022.06.20.496920
https://doi.org/10.1101/2022.06.20.496920
Publikováno v:
Metabolites, Vol 11, Iss 823, p 823 (2021)
Metabolites
Metabolites; Volume 11; Issue 12; Pages: 823
Metabolites
Metabolites; Volume 11; Issue 12; Pages: 823
Much progress has been made in improving the viable cell density of bioreactor cultures in monoclonal antibody production from Chinese hamster ovary (CHO) cells; however, specific productivity (qP) has not been increased to the same degree. In this w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b312a78b8f6111c30954b21a29cdde24
https://www.mdpi.com/2218-1989/11/12/823
https://www.mdpi.com/2218-1989/11/12/823
Akademický článek
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Autor:
Jianjie Ma, Hua Zhu, Naresh Kumar, Lisa E. Dorn, Federica Accornero, Adam D. Kenney, Jeffrey Kawahara, Adrian Eddy, Ashley Zani, Jacob S. Yount, Parker J. Denz, Murugesan V. S. Rajaram, Stephanie L. Aron, Peng Chen, Samuel Speaks, Clara Gilbert, Ryan A. Langlois, Chuanxi Cai, Lizhi Zhang, Nahara Vargas-Maldonado
Cardiac dysfunction is a common extrapulmonary complication of severe influenza virus infection. Prevailing models propose that influenza-associated heart dysfunction is indirectly triggered by cytokine mediated cardiotoxicity downstream of the infla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7a56afbc5db6e47c42290f82105ddd
https://doi.org/10.1101/2021.10.27.466128
https://doi.org/10.1101/2021.10.27.466128
Autor:
Xuankuo Xu, Anthony J. Cura, Seo-Young Park, Susan Egan, Sanchayita Ghose, Kyongbum Lee, Zheng Jian Li, Michael C. Borys, Mengyuan Zheng, Kathryn L. Aron
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Monoclonal antibody (mAb) interchain disulfide bond reduction can cause a loss of function and negatively impact the therapeutic’s efficacy and safety. Disulfide bond reduction has been observed at various stages during the manufacturing process, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18682e308bebfc430ff2a3cd021ea6f
https://pubmed.ncbi.nlm.nih.gov/34424810
https://pubmed.ncbi.nlm.nih.gov/34424810
Publikováno v:
Journal of Virology
Influenza A virus (IAV) is a respiratory pathogen that has caused significant mortality throughout history and remains a global threat to human health. Although much is known about IAV replication, the regulation of IAV replication dynamics is not co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad496a30f93677d38b8069dead477ea
https://pubmed.ncbi.nlm.nih.gov/33658346
https://pubmed.ncbi.nlm.nih.gov/33658346
Autor:
Eric S, Hall, Robert K, Hall, Sherman, Swanson, Wilson, Yee, Don, Kozlowski, Michael J, Philbin, Daniel T, Heggem, John, Lin, Joan L, Aron, Robin J, Schafer, David, Guiliano, Eric, Wilson
Publikováno v:
American journal of environmental engineering
Effective stream and wetland Best Management Practices (BMPs) restore the physical processes associated with ecological functions to their Proper Functioning Condition (PFC, i.e., the highest attainable ecological status of a riparian area without co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1153bd317d9e0591f825a889e4605c8e
https://pubmed.ncbi.nlm.nih.gov/32704436
https://pubmed.ncbi.nlm.nih.gov/32704436
Autor:
Lauren Jenkins, Anthony J. Cura, Sanchayita Ghose, Kathryn L. Aron, Yunping Huang, Tyler Hageman, Srinivas Chollangi, Xuankuo Xu, Michael C. Borys, Susan Egan, Zheng Jian Li
Publikováno v:
Applied microbiology and biotechnology. 104(22)
The disulfide reduction of intact monoclonal antibodies (mAbs) and subsequent formation of low molecular weight (LMW) species pose a direct risk to product stability, potency, and patient safety. Although enzymatic mechanisms of reduction are well es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6078e5efebd9cd854220d071d92488ee
https://pubmed.ncbi.nlm.nih.gov/32997205
https://pubmed.ncbi.nlm.nih.gov/32997205
Autor:
Matthew W. Markman, Marissa Macchietto, Katharina Esser-Nobis, Steven S. Shen, Ryan A. Langlois, Elizabeth J. Fay, Stephanie L. Aron, Michael Gale
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 8, p e1008760 (2020)
PLoS Pathogens, Vol 16, Iss 8, p e1008760 (2020)
Influenza A viruses (IAVs) remain a significant global health burden. Activation of the innate immune response is important for controlling early virus replication and spread. It is unclear how early IAV replication events contribute to immune detect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605158eb8649317399efc6f1837009ce
https://pubmed.ncbi.nlm.nih.gov/32790753
https://pubmed.ncbi.nlm.nih.gov/32790753