Zobrazeno 1 - 10
of 1 315
pro vyhledávání: '"L. Aravind"'
Autor:
Janani Ravi, Vivek Anantharaman, Samuel Zorn Chen, Evan Pierce Brenner, Pratik Datta, L. Aravind, Maria Laura Gennaro
Publikováno v:
mSystems, Vol 9, Iss 6 (2024)
ABSTRACT Bacterial phage shock protein (PSP) systems stabilize the bacterial cell membrane and protect against envelope stress. These systems have been associated with virulence, but despite their critical roles, PSP components are not well character
Externí odkaz:
https://doaj.org/article/53c2a124eac14d109b362da4b8a83293
Autor:
Taylor M. Gerson, Audrey M. Ott, Monika M. A. Karney, Jillian N. Socea, Daren R. Ginete, Lakshminarayan M. Iyer, L. Aravind, Ronald K. Gary, Helen J. Wing
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT The VirB protein, encoded by the large virulence plasmid of Shigella spp., is a key transcriptional regulator of virulence genes. Without virB, Shigella cells are avirulent. On the virulence plasmid, VirB functions to offset transcriptional
Externí odkaz:
https://doaj.org/article/fc3cc248550549869b8473588cb9be2a
Autor:
Pratik Rajendra Patil, A. Maxwell Burroughs, Mohit Misra, Federico Cerullo, Carlos Costas Insua, Hao-Chih Hung, Ivan Dikic, L. Aravind, Claudio A.P. Joazeiro
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113100- (2023)
Summary: In ribosome-associated quality control (RQC), nascent polypeptides produced by interrupted translation are modified with C-terminal polyalanine tails (“Ala-tails”) that function outside ribosomes to induce ubiquitylation by E3 ligases Pi
Externí odkaz:
https://doaj.org/article/9f8d3f9ceb3e41d9920d13ffab44615f
Autor:
Andrew J. Smith, Jayshree Advani, Daniel C. Brock, Jacob Nellissery, Jessica Gumerson, Lijin Dong, L. Aravind, Breandán Kennedy, Anand Swaroop
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-20 (2022)
Abstract Background Functional complexity of the eukaryotic mitochondrial proteome is augmented by independent gene acquisition from bacteria since its endosymbiotic origins. Mammalian homologs of many ancestral mitochondrial proteins have uncharacte
Externí odkaz:
https://doaj.org/article/abca2390cef14d15a89a878365c6270a
Autor:
Nitin Verma, Ankit Puri, Edward Essuman, Richard Skelton, Vivek Anantharaman, Hong Zheng, Siera White, Karthigayan Gunalan, Kazuyo Takeda, Surabhi Bajpai, Timothy J. Lepore, Peter J. Krause, L. Aravind, Sanjai Kumar
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract Babesia microti is an intraerythrocytic parasite and the primary causative agent of human babesiosis. It is transmitted by Ixodes ticks, transfusion of blood and blood products, organ donation, and perinatally. Despite its global public heal
Externí odkaz:
https://doaj.org/article/d8b8d02928364355960511831323b8a1
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
More than 100 Babesia spp. tick-borne parasites are known to infect mammalian and avian hosts. Babesia belong to Order Piroplasmid ranked in the Phylum Apicomplexa. Recent phylogenetic studies have revealed that of the three genera that constitute Pi
Externí odkaz:
https://doaj.org/article/dcd5eaee9d884155bcfe43b5235a25d7
Publikováno v:
Viruses, Vol 14, Iss 9, p 1977 (2022)
NAD+ and ADP-ribose (ADPr)-containing molecules are at the interface of virus–host conflicts across life encompassing RNA processing, restriction, lysogeny/dormancy and functional hijacking. We objectively defined the central components of the NAD+
Externí odkaz:
https://doaj.org/article/88c3f7e83c424f6c8aa83d93f521896c
Autor:
Samuel H. Becker, Kathrin Ulrich, Avantika Dhabaria, Beatrix Ueberheide, William Beavers, Eric P. Skaar, Lakshminarayan M. Iyer, L. Aravind, Ursula Jakob, K. Heran Darwin
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT The bacterial pathogen Mycobacterium tuberculosis is the leading cause of death by an infectious disease among humans. Here, we describe a previously uncharacterized M. tuberculosis protein, Rv0991c, as a molecular chaperone that is activate
Externí odkaz:
https://doaj.org/article/f5ea186d359e44bc9800d53283f1b1a1
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was recently identified as the causative agent for the coronavirus disease 2019 (COVID-19) outbreak that has generated a global health crisis. We use a combin
Externí odkaz:
https://doaj.org/article/3ca7adc8ad3644a1bc69e15825036095
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
The origin of eukaryotes was marked by the emergence of several novel subcellular systems. One such is the calcium (Ca2+)-stores system of the endoplasmic reticulum, which profoundly influences diverse aspects of cellular function including signal tr
Externí odkaz:
https://doaj.org/article/8740205a119049539d304753d89460d9