Zobrazeno 1 - 10
of 33
pro vyhledávání: '"L. A. O'Toole"'
Publikováno v:
Psychopharmacology. 157:96-104
Rationale: At high doses, methamphetamine produces repetitive stereotypic behaviors, and the degree to which this occurs is heritable. Objectives: Mice of a B6D2F2 genetic background were selectively bred for four generations for high (HMA) and low (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7742b2673a4182645ee9fb2319487269
https://doi.org/10.1007/s002130100774
https://doi.org/10.1007/s002130100774
Autor:
John K. Belknap, L. A. O'Toole, Melinda L. Helms, Mark W. Jarvis, Susan E. Bergeson, Jeffrey S. Mogil, Heather S. Hain
Publikováno v:
Mammalian Genome. 12:546-553
Analgesia (pain reduction, or antinociception) is a classical and clinically important effect of morphine administration, and in rodent models sensitivity to morphine has been shown to be strongly influenced by genotype. For example, several studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95131b5db16d8e1ba1ea7765fd8d3baf
https://doi.org/10.1007/s003350020022
https://doi.org/10.1007/s003350020022
Autor:
Benjamin Kest, Steve R. Mitchell, John K. Belknap, L. A. O'Toole, Melinda L. Helms, S. P. Richards, Jeffrey S. Mogil
Publikováno v:
The Journal of Neuroscience. 17:7995-8002
It is increasingly appreciated that the sexes differ in their perception of noxious stimuli and in their responsivity to exogenous and endogenous analgesic manipulations. We previously reported the existence of qualitative sex differences in the neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a707c3344bcc4b9e4df96fbed45e5331
https://doi.org/10.1523/jneurosci.17-20-07995.1997
https://doi.org/10.1523/jneurosci.17-20-07995.1997
Autor:
John K. Belknap, L. A. O'Toole, Judith E. Grisel, Charlotte D. Wenger, Melinda L. Helms, John C. Crabbe
Publikováno v:
The Journal of Neuroscience. 17:745-754
Individual differences in most behavioral and pharmacological responses to abused drugs are dependent on both genetic and environmental factors. The genetic influences on the complex phenotypes related to drug abuse have been difficult to study using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3738ccbdb2a9d48b071b35c72e8710
https://doi.org/10.1523/jneurosci.17-02-00745.1997
https://doi.org/10.1523/jneurosci.17-02-00745.1997
Publikováno v:
Behavior Genetics. 27:55-66
Short-term selective breeding starting from an F2 intercross of two inbred strains is a largely unexploited but potentially useful tool for quantitative trait locus (QTL) mapping. The selection lines can also serve as a valuable confirmation test of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ec2b86890a635cf51c24eef51a41769
https://doi.org/10.1023/a:1025615409383
https://doi.org/10.1023/a:1025615409383
Publikováno v:
Behavior Genetics. 26:149-160
Effective mapping strategies for quantitative traits must allow for the detection of the more important quantitative trait loci (QTLs) while minimizing false positives. Type I (false-positive) and Type II (false-negative) error rates were estimated f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7bb0b9a3e17ad22691ea7f421b8536a
https://doi.org/10.1007/bf02359892
https://doi.org/10.1007/bf02359892
Autor:
K.J. Buck, Melinda L. Helms, S.E. Bergeson, L. A. O'Toole, S. P. Richards, John K. Belknap, Jeffrey S. Mogil
Publikováno v:
Life Sciences. 57:PL117-PL124
A quantitative trait locus (QTL) was detected and mapped to proximal chromosome 10 near the markers Mpmv5 and D10Mit51 with a strong influence on morphine-induced analgesia in the BXD recombinant inbred (Rl) strains and in an F2 cross (B6D2F2) betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a21dece9e7e6b13d0f01e2d85aef0f8
https://doi.org/10.1016/0024-3205(95)02040-p
https://doi.org/10.1016/0024-3205(95)02040-p
μ-Opiate receptor binding is up-regulated in mice selectively bred for high stress-induced analgesia
Autor:
Bogdan Sadowski, John C. Liebeskind, John K. Belknap, Jeffrey S. Mogil, Przemyslaw Marek, Melinda L. Helms, L. A. O'Toole
Publikováno v:
Brain Research. 653:16-22
Pain perception and sensitivity to opiate analgesics strongly depend on genotype. Mice selectively bred for high (HA) and low (LA) swim stress-induced analgesia display markedly divergent morphine analgesia, a difference that appears to be determined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffdfe2124b5afd0c88bb95db9cf5098e
https://doi.org/10.1016/0006-8993(94)90366-2
https://doi.org/10.1016/0006-8993(94)90366-2
Publikováno v:
Psychopharmacology. 112:352-358
To determine genetic differences in voluntary morphine consumption, 15 commonly used inbred strains of mice were given ad libitum two-bottle choice between saccharin alone or saccharin/morphine in one bottle and water in the other bottle. Subsequentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edea03210367d51071d5116dcfa344d9
https://doi.org/10.1007/bf02244932
https://doi.org/10.1007/bf02244932
Publikováno v:
Journal of Endocrinology. 138:275-282
The putative osmoregulatory role of the unique elasmobranch corticosteroid, 1α-hydroxycorticosterone (1α-OH-B), was investigated using dietary protein restriction as a means of limiting urea biosynthetic ability. Groups of dogfish (Scyliorhinus can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de2d278c4c076f4fb5b9c4594879c01
https://doi.org/10.1677/joe.0.1380275
https://doi.org/10.1677/joe.0.1380275