Zobrazeno 1 - 10
of 13
pro vyhledávání: '"L. A. Kohlstaedt"'
Autor:
Thomas A. Steitz, Jonathan M. Friedman, Jianbin Wang, Phoebe A. Rice, L. A. Kohlstaedt, Stephen J. Smerdon, J. Jäger
The reverse transcriptase from human immunodeficiency virus type 1 is a heterodimer consisting of one 66-kDa and one 51-kDa subunit. The p66 subunit contains both a polymerase and an RNase H domain; proteolytic cleavage of p66 removes the RNase H dom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce62468710472dd74598877d3eca057
https://doi.org/10.1142/9789811215865_0031
https://doi.org/10.1142/9789811215865_0031
Autor:
M. J. Radeke, A. M. Giannetti, M. F. Chau, G. Lindwall, Stuart C. Feinstein, L. A. Kohlstaedt
Publikováno v:
Protein Science. 9:2427-2435
We have used X-ray fiber diffraction to probe the structure of fibers of tau and tau fragments. Fibers of fragments from the microtubule binding domain had a cross beta-structure that closely resembles that reported both for neurofibrillary tangles f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12350b47516e189aff0c84f0628630b4
https://doi.org/10.1110/ps.9.12.2427
https://doi.org/10.1110/ps.9.12.2427
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
The interaction between tubulin subunits and microtubule-associated proteins (MAPs) such as tau is fundamental for microtubule structure and function. Previous work has suggested that the 'microtubule biding domain' of tau (composed of three or four
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4078ffb9c6564b438331a18b852ee01
https://doi.org/10.1021/bi9812118
https://doi.org/10.1021/bi9812118
Publikováno v:
Journal of molecular biology. 291(3)
We have identified an additional dimerization linkage structure in the genome of Moloney murine leukemia virus (MoMLV). Retroviral genomes have long been known to be linked at their 5' ends to form dimers. In MoMLV, a hairpin loop functioning as a di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::01c2e30161744e0a6837bed7e59421be
https://pubmed.ncbi.nlm.nih.gov/10448040
https://pubmed.ncbi.nlm.nih.gov/10448040
Autor:
Thomas A. Steitz, Jonathan M. Friedman, Stephen J. Smerdon, J. Jäger, Jui H. Wang, A J Chirino, L. A. Kohlstaedt, Phoebe A. Rice
The dipyridodiazepinone Nevirapine is a potent and highly specific inhibitor of the reverse transcriptase (RT) from human immunodeficiency virus type 1 (HIV-1). It is a member of an important class of nonnucleoside drugs that appear to share part or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0726abecf457e652e9253e6c7393131
https://europepmc.org/articles/PMC43692/
https://europepmc.org/articles/PMC43692/
Autor:
Thomas A. Steitz, Jui H. Wang, Phoebe A. Rice, L. A. Kohlstaedt, Jonathan M. Friedman, D. Boisvert
Publikováno v:
Protein Engineering, Design and Selection.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97343757c328193421a1106cdfd25359
https://doi.org/10.1093/protein/6.supplement.108
https://doi.org/10.1093/protein/6.supplement.108
Autor:
L. A. Kohlstaedt, Thomas A. Steitz
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 89(20)
Although the reverse transcriptase (RT) of human immunodeficiency virus (HIV) uses human tRNA(3Lys) as a primer of viral genome DNA synthesis in vivo, HIV RT binds Escherichia coli glutamine tRNA and in vitro-made human lysine tRNA with nearly equiva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6899c89f97776f2fe4f2b671efbcb058
https://pubmed.ncbi.nlm.nih.gov/1384059
https://pubmed.ncbi.nlm.nih.gov/1384059
Publikováno v:
Science (New York, N.Y.). 256(5065)
A 3.5 angstrom resolution electron density map of the HIV-1 reverse transcriptase heterodimer complexed with nevirapine, a drug with potential for treatment of AIDS, reveals an asymmetric dimer. The polymerase (pol) domain of the 66-kilodalton subuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be949d704b496905010d67c9b76b399
https://pubmed.ncbi.nlm.nih.gov/1377403
https://pubmed.ncbi.nlm.nih.gov/1377403