Zobrazeno 1 - 10
of 307
pro vyhledávání: '"L. A. Jacobson"'
Autor:
Jack Polmear, Lauren Hailes, Moshe Olshansky, Maureen Rischmueller, Elan L'Estrange‐Stranieri, Anne L Fletcher, Margaret L Hibbs, Vanessa L Bryant, Kim L Good‐Jacobson
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 10, Pp n/a-n/a (2023)
Abstract Objectives B cells drive the production of autoreactive antibody‐secreting cells (ASCs) in autoimmune diseases such as Systemic Lupus Erythematosus (SLE) and Sjögren's syndrome, causing long‐term organ damage. Current treatments for ant
Externí odkaz:
https://doaj.org/article/a2cc8dc41eea467d987f4c8b9f2b2986
Autor:
Deepak Bushan Raina, Yang Liu, Otto L. P. Jacobson, K Elizabeth Tanner, Magnus Tägil, Lars Lidgren
Publikováno v:
Bone & Joint Research, Vol 9, Iss 10, Pp 709-718 (2020)
Bone is a dynamic tissue with a quarter of the trabecular and a fifth of the cortical bone being replaced continuously each year in a complex process that continues throughout an individual’s lifetime. Bone has an important role in homeostasis of m
Externí odkaz:
https://doaj.org/article/a3c0b070963444a392db6474232ae725
Autor:
Kylie M. Quinn, Tabinda Hussain, Felix Kraus, Luke E. Formosa, Wai K. Lam, Michael J. Dagley, Eleanor C. Saunders, Lisa M. Assmus, Erica Wynne-Jones, Liyen Loh, Carolien E. van de Sandt, Lucy Cooper, Kim L. Good-Jacobson, Katherine Kedzierska, Laura K. Mackay, Malcolm J. McConville, Georg Ramm, Michael T. Ryan, Nicole L. La Gruta
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Fatty acid oxidation (FAO) is thought to contribute to high spare respiratory capacity (SRC), which in turn affects CD8+ T cell function. Here, the authors show that ex vivo virtual memory T cells (and not antigen experienced memory T cells) have hig
Externí odkaz:
https://doaj.org/article/6da73ceced984a059e48b4f7619a183a
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 5, p e0009340 (2021)
The current approaches to reduce the burden of chronic helminth infections in endemic areas are adequate sanitation and periodic administration of deworming drugs. Yet, resistance against some deworming drugs and reinfection can still rapidly occur e
Externí odkaz:
https://doaj.org/article/af0853be025b41d1829541c9c44a78f9
Autor:
Liam Kealy, Andrea Di Pietro, Lauren Hailes, Sebastian Scheer, Lennard Dalit, Joanna R. Groom, Colby Zaph, Kim L. Good-Jacobson
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108504- (2020)
Summary: Histone modifiers are essential for the ability of immune cells to reprogram their gene expression during differentiation. The recruitment of the histone methyltransferase DOT1L (disruptor of telomeric silencing 1-like) induces oncogenic gen
Externí odkaz:
https://doaj.org/article/b1306c7f292b4b7d8367714d8c0cab9c
Autor:
Dana Piovesan, Jessica Tempany, Andrea Di Pietro, Inge Baas, Callisthenis Yiannis, Kristy O’Donnell, Yunshun Chen, Victor Peperzak, Gabrielle T. Belz, Charles R. Mackay, Gordon K. Smyth, Joanna R. Groom, David M. Tarlinton, Kim L. Good-Jacobson
Publikováno v:
Cell Reports, Vol 19, Iss 3, Pp 461-470 (2017)
Summary: Humoral immune responses are tailored to the invading pathogen through regulation of key transcription factors and their networks. This is critical to establishing effective antibody-mediated responses, yet it is unknown how B cells integrat
Externí odkaz:
https://doaj.org/article/3c81bb09b0d54bd388012d93887c7861
Autor:
Ann Ly, Yang Liao, Halina Pietrzak, Lisa J. Ioannidis, Tom Sidwell, Renee Gloury, Marcel Doerflinger, Tony Triglia, Raymond Z. Qin, Joanna R. Groom, Gabrielle T. Belz, Kim L. Good-Jacobson, Wei Shi, Axel Kallies, Diana S. Hansen
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2257-2269.e6 (2019)
Summary: Despite the key role that antibodies play in protection, the cellular processes mediating the acquisition of humoral immunity against malaria are not fully understood. Using an infection model of severe malaria, we find that germinal center
Externí odkaz:
https://doaj.org/article/6f67331c6da645a1a983b3853dcaa0bf
Autor:
Amania A. Sheikh, Lucy Cooper, Meiqi Feng, Fernando Souza-Fonseca-Guimaraes, Fanny Lafouresse, Brigette C. Duckworth, Nicholas D. Huntington, James J. Moon, Marc Pellegrini, Stephen L. Nutt, Gabrielle T. Belz, Kim L. Good-Jacobson, Joanna R. Groom
Publikováno v:
Cell Reports, Vol 28, Iss 7, Pp 1758-1772.e4 (2019)
Summary: Following infection, inflammatory cues upregulate core transcriptional programs to establish pathogen-specific protection. In viral infections, T follicular helper (TFH) cells express the prototypical T helper 1 transcription factor T-bet. S
Externí odkaz:
https://doaj.org/article/cd5c2f99504b4133b0cdd744e3118bd0
Autor:
Liam Kealy, Kim L Good‐Jacobson
Publikováno v:
Immunology & Cell Biology. 100:308-311
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4652bc2a160fa09c602ff3e1c28f3902
https://doi.org/10.1111/imcb.12548
https://doi.org/10.1111/imcb.12548
Autor:
Lucy Cooper, Hui Xu, Jack Polmear, Christopher Szeto, Ee Shan Pang, Mansi Gupta, Justin J Taylor, Katherine J L Jackson, Angela Nguyen, Nicole La Gruta, Luciano Martelotto, Ian A Parish, Meredith O’Keeffe, Christopher D Scharer, Stephanie Gras, Kim L Good-Jacobson
SUMMARYMemory B cells are key providers of long-lived immunity against infectious disease, yet in chronic viral infection they do not produce effective protection. How chronic viral infection disrupts memory B cell development, and whether such chang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df4e7f1c5877d06f2c60bb5334baf402
https://doi.org/10.1101/2023.03.02.530850
https://doi.org/10.1101/2023.03.02.530850
