Výsledky vyhledávání

Identifying dysregulated immune cell subsets following critical volumetric muscle loss with pseudo-time trajectories

Autor: Hong Seo Lim, Nick J. Willett, Shannon E. Anderson, Edward A. Botchwey, L. A. Hymel, Peng Qiu, William Y. York, Young C. Jang, Thomas C. Turner

Volumetric muscle loss (VML) results in permanent functional deficits and remains a substantial regenerative medicine challenge. A coordinated immune response is crucial for timely myofiber regeneration, however the immune response following VML has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57377f7b5cd301971ce2959ecf74fcd2
https://doi.org/10.1101/2021.05.25.445480

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Harnessing lipid signaling pathways to target specialized pro-angiogenic neutrophil subsets for regenerative immunotherapy

Autor: Gabriel A. Kwong, Hong Seo Lim, F. S. Pittman, Thomas C. Turner, Edward A. Botchwey, Quoc D. Mac, William Y. York, Peng Qiu, Mary Caitlin P. Sok, L. A. Hymel, S. Vyshnya

Publikováno v: Science Advances

Local delivery of a pro-resolving lipid mediator leads to a shift in the immune microenvironment and improves wound healing.
To gain insights into neutrophil heterogeneity dynamics in the context of sterile inflammation and wound healing, we per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052347bd70bc4d4549f089c887785765
http://europepmc.org/articles/PMC7608810

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Local delivery of FTY720 induces neutrophil activation through chemokine signaling in an oronasal fistula model

Autor: Archana Kamalakar, Samir A. Ballestas, Edward A. Botchwey, R Johnston, J Randall, L. A. Hymel, Angélica M. Amanso, Nick J. Willett, Thomas C. Turner, RA Arthur, Steve Goudy

Publikováno v: Regenerative Engineering and Translational Medicine

Purpose Cleft palate repair surgeries lack a regenerative reconstructive option and, in many cases, develop complications including oronasal fistula (ONF). Our group has developed a novel murine phenocopy of ONF to study the oral cavity wound healing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb1dc9f00702f93694a9555fceda20c
https://pubmed.ncbi.nlm.nih.gov/34722855

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Modulating local S1P receptor signaling as a regenerative immunotherapy after volumetric muscle loss injury

Autor: Shannon E. Anderson, Claire E. Olingy, Edward A. Botchwey, Alan Y. Liu, L. A. Hymel, Hong Seo Lim, Sraeyes Sridhar, Cheryl L. San Emeterio, Young C. Jang, Thomas C. Turner, William Y. York, Todd Sulchek, Nick J. Willett, Molly E. Ogle, Peng Qiu

Publikováno v: J Biomed Mater Res A

Regeneration of skeletal muscle after volumetric injury is thought to be impaired by a dysregulated immune microenvironment that hinders endogenous repair mechanisms. Such defects result in fatty infiltration, tissue scarring, chronic inflammation, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d9b9def10124659d9e0948750d5e4a
https://pubmed.ncbi.nlm.nih.gov/32608188

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Dual delivery of IL-10 and AT-RvD1 from PEG hydrogels polarize immune cells towards pro-regenerative phenotypes

Autor: Edward A. Botchwey, Joshua I. Palacios, Andrés J. García, Mary Caitlin P. Sok, Hong Seo Lim, José R. García, Claire McClain, Peng Qiu, Molly E. Ogle, Claire E. Olingy, Nusaiba Baker, Thomas C. Turner, Krithik Srithar, L. A. Hymel

Publikováno v: Biomaterials. 268

Inflammation after traumatic injury or surgical intervention is both a protective tissue response leading to regeneration and a potential cause of wound complications. One potentially successful strategy to harness to pro-regenerative roles of host i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7414f1ddd18a062c0f1092bed14dfaea
https://pubmed.ncbi.nlm.nih.gov/33321293

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Isolation and characterization of membrane potential changes associated with release of calcium from intracellular stores in rat thymic lymphocytes

Autor: M. P. Mahaut-Smith, O. I. Wilson, I. Marriott, Michael J. Mason, L. J. Hymel

Publikováno v: The Journal of Membrane Biology. 137

Membrane potential changes accompanying Ca2+ influx stimulated by release of Ca2+ from intracellular stores (store-regulated Ca2+ uptake) were monitored in BAPTA-loaded rat thymic lymphocytes using the fluorescent indicator bis(1,3-diethylthiobarbitu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b327f4e186a04c0dd0f80e2116796d8b
https://doi.org/10.1007/bf00233485

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