Zobrazeno 1 - 10
of 167
pro vyhledávání: '"L. A. H. Borg"'
Publikováno v:
Journal of Endocrinology. 185:291-299
The pancreatic B-cell GLUT2 transporter and glucose metabolism were examined in isolated rat islets subjected to treatments affecting insulin secretion. Diazoxide was used to inhibit, while glipizide or depolarization of the plasma membrane with a hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b9a05635dbda31d96427f27b6b20a2
https://doi.org/10.1677/joe.1.05701
https://doi.org/10.1677/joe.1.05701
Publikováno v:
Endocrinology. 140:3422-3428
The aim of the present investigation was to study whether prolonged exposure of isolated rat islets to the long chain fatty acid sodium palmitate leads to uncoupling of respiration. It was found that culture of islets in the presence of palmitate abo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dd6cb6df6f26fbddb871c36c313b539
https://doi.org/10.1210/endo.140.8.6908
https://doi.org/10.1210/endo.140.8.6908
Publikováno v:
Life Sciences. 62:293-300
Hyperketonemia has been identified as an important factor in diabetic pregnancy affecting growth and development of the offspring. In order to assess the immediate metabolic alterations in embryos caused by excess ketone bodies, we studied rat embryo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da218b2dbd76ae6327f21bcdb602b0b7
https://doi.org/10.1016/s0024-3205(97)01110-7
https://doi.org/10.1016/s0024-3205(97)01110-7
Altered metabolism and superoxide generation in neural tissue of rat embryos exposed to high glucose
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 272:E173-E180
Oxygen uptake and glucose utilization of embryonic and fetal neural tissue of normal and diabetic rat pregnancy were studied. Exposure to 50 mM glucose inhibited oxygen uptake of embryonic neural tissue of normal rats by 28% at gestational day 9 (P <
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ac7c3747f511a7b688056fd15a2023
https://doi.org/10.1152/ajpendo.1997.272.1.e173
https://doi.org/10.1152/ajpendo.1997.272.1.e173
Autor:
L. A. H. Borg, Marie-Hélène Giroix, C. Saulnier, Patricia Serradas, Bernard Portha, Marie-Noëlle Gangnerau, Michael Welsh, N. Welsh
Publikováno v:
Endocrinology. 136:5623-5631
Considerable interest has recently been focused on the putative role of mutations in the mitochondrial genome for the development of noninsulin-dependent diabetes. The Goto-Kakizaki (GK) rat, a genetic model of defective insulin secretion and hypergl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2112c1af65b86bb3873cfd2ad01a6cd8
https://doi.org/10.1210/endo.136.12.7588317
https://doi.org/10.1210/endo.136.12.7588317
Autor:
Claes Hellerström, H Jernberg Wiklund, L A H Borg, M A Mello, Arne Andersson, Decio L. Eizirik, Johan Saldeen, Daniel Pipeleers, B Margulis, Nils Welsh, Malin Flodström
Publikováno v:
Molecular Medicine. 1:806-820
Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: Implications for the pathogenesis of insulin-dependent diabetes mellitus.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbb6af72d4f6706d760363832bb9fc25
https://doi.org/10.1007/bf03401895
https://doi.org/10.1007/bf03401895
Autor:
Leif Jansson, L A H Borg, Claes Hellerström, Daniel Pipeleers, Decio L. Eizirik, Agneta Andersson
Publikováno v:
Journal of Clinical Investigation. 96:721-726
Hyperglycemia-induced beta-cell dysfunction may be an important component in the pathogenesis of non-insulin-dependent diabetes mellitus. However, most available data in this field were obtained from rodent islets. To investigate the relevance of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce038f85afac61100922005cfde3ce4a
https://doi.org/10.1172/jci118115
https://doi.org/10.1172/jci118115
Publikováno v:
The Anatomical Record. 241:255-267
Background: Previous studies in vivo and in vitro have suggeted that the oxidative metabolism of the embryo may have a role in the treatogenicity of diabetic pregnancy. In particular, the production of reactive oxygen species by the embroyonic mitoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f584e208058773e2314d36f776a98c13
https://doi.org/10.1002/ar.1092410212
https://doi.org/10.1002/ar.1092410212
Publikováno v:
Diabetologia. 35:939-945
Kwashiorkor, the human disease of protein-energy malnutrition, has been implicated in the aetiology of malnutrition-related diabetes mellitus, a form of diabetes not uncommon in developing countries. We have previously demonstrated that temporary pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667d3153bd7e599da749b4108f3feb4d
https://doi.org/10.1007/bf00401422
https://doi.org/10.1007/bf00401422
Publikováno v:
Endocrinology. 130:2851-2857
The suppressive effects of interleukin-1 beta (IL-1 beta) on the function of pancreatic islets may be related to induction of gene transcription and protein synthesis. Presently, the effects of human recombinant IL-1 beta (rIL-1 beta) on the activiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7009a747fa11940e9641ed0769b233
https://doi.org/10.1210/endo.130.5.1533363
https://doi.org/10.1210/endo.130.5.1533363