Zobrazeno 1 - 10
of 597
pro vyhledávání: '"L. A. Edwards"'
Publikováno v:
The Cryosphere, Vol 10, Pp 2399-2413 (2016)
Glaciers of the Bolivian Andes represent an important water resource for Andean cities and mountain communities, yet relatively little work has assessed changes in their extent over recent decades. In many mountain regions, glacier recession has b
Externí odkaz:
https://doaj.org/article/27cdca3d06404c85b6116020405144be
Autor:
Tailise Carolina de Souza-Guerreiro, Letícia Huan Bacellar, Thyerre Santana da Costa, Conor L. A. Edwards, Ljubica Tasic, Munehiro Asally
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT Membrane potential is a useful marker for antimicrobial susceptibility testing (AST) due to its fundamental roles in cell function. However, the difficulties associated with measuring the membrane potential in microbes restrict its broad app
Externí odkaz:
https://doaj.org/article/01aab40baab646199345c931e8204bd4
Autor:
Dana K Pasquale, Whitney Welsh, Keisha L Bentley-Edwards, Andrew Olson, Madelynn C Wellons, James Moody
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0303677 (2024)
Community mixing patterns by sociodemographic traits can inform the risk of epidemic spread among groups, and the balance of in- and out-group mixing affects epidemic potential. Understanding mixing patterns can provide insight about potential transm
Externí odkaz:
https://doaj.org/article/71ea303271174fe692d145b1e9165787
Autor:
Manuela Corti, Barry J. Byrne, Dominic J. Gessler, Grace Thompson, Samantha Norman, Jenna Lammers, Kirsten E. Coleman, Cristina Liberati, Melissa E. Elder, Maria L. Escolar, Ibrahim S. Tuna, Clementina Mesaros, Gary I. Kleiner, Deborah S. Barbouth, Heather L. Gray-Edwards, Nathalie Clement, Brian D. Cleaver, Guangping Gao
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 303-314 (2023)
Gene replacement therapy is a rational therapeutic strategy and clinical intervention for neurodegenerative disorders like Canavan disease, a leukodystrophy caused by biallelic mutations in the aspartoacylase (ASPA) gene. We aimed to investigate whet
Externí odkaz:
https://doaj.org/article/9c3eeeaf5a4542ada6da05e007811039
Autor:
Hector Ribeiro Benatti, Rachel D. Prestigiacomo, Toloo Taghian, Rachael Miller, Robert King, Matthew J. Gounis, Ugur Celik, Stephanie Bertrand, Susan Tuominen, Lindsey Bierfeldt, Elizabeth Parsley, Jillian Gallagher, Erin F. Hall, Abigail W. McElroy, Miguel Sena-Esteves, Anastasia Khvorova, Neil Aronin, Heather L. Gray-Edwards
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101122- (2023)
Oligonucleotide therapeutics offer great promise in the treatment of previously untreatable neurodegenerative disorders; however, there are some challenges to overcome in pre-clinical studies. (1) They carry a well-established dose-related acute neur
Externí odkaz:
https://doaj.org/article/47746a402a8d49c9b29336720b82daae
Autor:
Michaël Hocquemiller, Laura Giersch, Xin Mei, Amanda L. Gross, Ashley N. Randle, Heather L. Gray-Edwards, Judith A. Hudson, Sophia Todeasa, Lorelei Stoica, Douglas R. Martin, Miguel Sena-Esteves, Karen Aiach, Ralph Laufer
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 281-292 (2022)
GM1 gangliosidosis is a rare, inherited neurodegenerative disorder caused by mutations in the GLB1 gene, which encodes the lysosomal hydrolase acid β-galactosidase (β-gal). β-gal deficiency leads to toxic accumulation of GM1 ganglioside, predomina
Externí odkaz:
https://doaj.org/article/157bca7427c44bc4a59c76e532caa74e
Autor:
Pamela Kell, Rohini Sidhu, Mingxing Qian, Sonali Mishra, Elena-Raluca Nicoli, Precilla D'Souza, Cynthia J. Tifft, Amanda L. Gross, Heather L. Gray-Edwards, Douglas R. Martin, Miguel Sena- Esteves, Dennis J. Dietzen, Manmilan Singh, Jingqin Luo, Jean E. Schaffer, Daniel S. Ory, Xuntian Jiang
Publikováno v:
EBioMedicine, Vol 92, Iss , Pp 104627- (2023)
Summary: Background: GM1 gangliosidosis is a rare, fatal, neurodegenerative disease caused by mutations in the GLB1 gene and deficiency in β-galactosidase. Delay of symptom onset and increase in lifespan in a GM1 gangliosidosis cat model after adeno
Externí odkaz:
https://doaj.org/article/c41107db896a498c9a58d10f4784660e
Autor:
Toloo Taghian, Ana Rita Batista, Sarah Kamper, Michael Caldwell, Laura Lilley, Hao Li, Paola Rodriguez, Katerina Mesa, Shaokuan Zheng, Robert M. King, Matthew J. Gounis, Sophia Todeasa, Anne Maguire, Douglas R. Martin, Miguel Sena-Esteves, Thomas J. Meade, Heather L. Gray-Edwards
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 128-134 (2021)
Transformative results of adeno-associated virus (AAV) gene therapy in patients with spinal muscular atrophy and Leber’s congenital amaurosis led to approval of the first two AAV products in the United States to treat these diseases. These extraord
Externí odkaz:
https://doaj.org/article/c16bf88485644845ad32d3c283989ad8
Autor:
Heather L. Gray-Edwards, Anne S. Maguire, Nouha Salibi, Lauren E. Ellis, Taylor L. Voss, Elise B. Diffie, Jey Koehler, Ashley N. Randle, Amanda R. Taylor, Brandon L. Brunson, Thomas S. Denney, Ronald J. Beyers, Atoska S. Gentry, Amanda L. Gross, Ana R. Batista, Miguel Sena-Esteves, Douglas R. Martin
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 258-270 (2020)
GM1 gangliosidosis (GM1) is a fatal neurodegenerative lysosomal storage disease that occurs most commonly in young children, with no effective treatment available. Long-term follow-up of GM1 cats treated by bilateral thalamic and deep cerebellar nucl
Externí odkaz:
https://doaj.org/article/e5a002b5c4934f989fe4e2733f002031
Autor:
Emily C Graff, J Nicholas Cochran, Christopher B Kaelin, Kenneth Day, Heather L Gray-Edwards, Rie Watanabe, Jey W Koehler, Rebecca A Falgoust, Jeremy W Prokop, Richard M Myers, Nancy R Cox, Gregory S Barsh, Douglas R Martin, Lives Consortium
Publikováno v:
PLoS Genetics, Vol 16, Iss 12, p e1008671 (2020)
Cerebral cortical size and organization are critical features of neurodevelopment and human evolution, for which genetic investigation in model organisms can provide insight into developmental mechanisms and the causes of cerebral malformations. Howe
Externí odkaz:
https://doaj.org/article/f72c12a217e54356ab20a16d694c65c4