Výsledky vyhledávání

Beta2 integrins are not required for tyrosine phosphorylation of paxillin in human neutrophils

Autor: R Fernandez, L A Boxer, S J Suchard

Publikováno v: The Journal of Immunology. 159:5568-5575

Although many of the receptors mediating neutrophil (polymorphonuclear leukocyte (PMN)) adhesion to extracellular matrix (ECM) proteins have been identified, the signal transduction pathways leading to cell spreading are not clearly defined. Studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::035c42a525dfa3f2242ef0447bca188e
https://doi.org/10.4049/jimmunol.159.11.5568

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Mitogen-activated protein kinase activation during IgG-dependent phagocytosis in human neutrophils: inhibition by ceramide

Autor: S J Suchard, P J Mansfield, L A Boxer, J A Shayman

Publikováno v: The Journal of Immunology. 158:4961-4967

In FMLP-activated polymorphonuclear leukocytes (PMNs) challenged with IgG-opsonized erythrocytes (EIgG), the termination of phagocytosis correlates with an accumulation of ceramide, a product of sphingolipid metabolism. Furthermore, the exogenous add

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::654f22de3c6450a6d6e98f1db11e1771
https://doi.org/10.4049/jimmunol.158.10.4961

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Human urokinase-type plasminogen activator primes neutrophils for superoxide anion release. Possible roles of complement receptor type 3 and calcium

Autor: D Cao, I F Mizukami, B A Garni-Wagner, A L Kindzelskii, R F Todd, L A Boxer, H R Petty

Publikováno v: The Journal of Immunology. 154:1817-1829

Urokinase-type plasminogen activator (uPA), which binds to cells via a specific receptor (uPAR), participates in pericellular proteolysis during leukocyte migration. Previous studies have indicated that uPAR is physically associated with CR3 (CD11b/C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bda6a7fdd804ef8d69ef3e743dc2b90
https://doi.org/10.4049/jimmunol.154.4.1817

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Granulocyte colony-stimulating factor (G-CSF) production and G-CSF receptor structure in patients with congenital neutropenia

Autor: S C, Guba, C A, Sartor, R, Hutchinson, L A, Boxer, S G, Emerson

Publikováno v: Blood. 83:1486-1492

Congenital neutropenia (Kostmann's syndrome [KS]) is an autosomal recessive syndrome that is characterized by profound neutropenia, resulting in major clinical infections and death. Since the neutropenia and symptoms in KS improve in response to exog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c2d2d46dedb97760faaa14d0b5586e
https://doi.org/10.1182/blood.v83.6.1486.bloodjournal8361486

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Lectin-like inhibition of immune complex receptor-mediated stimulation of neutrophils. Effects on cytosolic calcium release and superoxide production

Autor: G Sehgal, K Zhang, R F Todd, L A Boxer, H R Petty

Publikováno v: The Journal of Immunology. 150:4571-4580

We have tested the role of lectin-like interactions, with particular emphasis on CR3, in insoluble immune complex (IC)-mediated activation of human polymorphonuclear leukocytes (PMN). The ability of IC to trigger intracellular Ca2+ release and O2- pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e328422e15f6d54c30bb5a9cf76f037b
https://doi.org/10.4049/jimmunol.150.10.4571

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Purification of PKC-I, an endogenous protein kinase C inhibitor, and types II and III protein kinase C isoenzymes from human neutrophils

Autor: K J Balazovich, L A Boxer, E L McEwen, T White, M L Lutzke

Publikováno v: Biochemical Journal. 284:399-405

Human neutrophil protein kinase C (PKC) activity is inhibited by an endogenous protein found primarily in the pellet fraction from homogenized specific granules, which was both heat- and proteinase-sensitive [Balazovich, Smolen & Boxer (1986) J. Immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ab79e079fbdee4472bf36f2b75b25e
https://doi.org/10.1042/bj2840399

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Activation of human neutrophils increases thrombospondin receptor expression

Autor: S J Suchard, L A Boxer, V M Dixit

Publikováno v: The Journal of Immunology. 147:651-659

Thrombospondin (TSP), a 450-kDa extracellular matrix protein secreted by platelets may be instrumental in triggering polymorphonuclear leukocyte (PMN) activation and mediating PMN-endothelial cell interactions. TSP alone had no effect on O-2 generati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::449b2b4efd4b41ffe8cb0bea7541701e
https://doi.org/10.4049/jimmunol.147.2.651

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Human neutrophil adherence to thrombospondin occurs through a CD11/CD18-independent mechanism

Autor: S J Suchard, M J Burton, V M Dixit, L A Boxer

Publikováno v: The Journal of Immunology. 146:3945-3952

Thrombospondin (TSP), a 450-kDa trimeric glycoprotein secreted by platelets and endothelial cells at sites of tissue injury or inflammation, may play an important role in polymorphonuclear leukocyte (PMN) adherence to blood vessel walls before diaped

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e69950afc521a3e6540992e13dbea149
https://doi.org/10.4049/jimmunol.146.11.3945

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