In vitro biological activity of Salvia fruticosa Mill. infusion against amyloid β-peptide-induced toxicity and inhibition of GSK-3β, CK-1δ, and BACE-1 enzymes relevant to Alzheimer's disease

Autor: Perihan Gürbüz, Alim Hüseyin Dokumacı, Miyase Gözde Gündüz, Concepcion Perez, Fatih Göger, Mehmet Yavuz Paksoy, Mükerrem Betül Yerer, L. Ömür Demirezer

Publikováno v: Saudi Pharmaceutical Journal, Vol 29, Iss 3, Pp 236-243 (2021)

Salvia species have been traditionally used to improve cognition and have been proved to be a potential natural treatment for Alzheimer’s disease. Salvia fruticosa Mill. (Turkish sage or Greek sage) demonstrated to have anticholinergic effects in v

Externí odkaz: https://doaj.org/article/0ab11c468ca8424e9e0d31159b65ab19

Development of a new validated HPLC method for the chemical specification of Rosa damascena petals

Autor: Osman Tuncay Agar, L. Ömür Demirezer

Publikováno v: Journal of Liquid Chromatography & Related Technologies. 44:320-328

Economical and fast analytical methods are required to determine the content of herbs and herbal medicine. With the increasing interest in rose tea and products prepared from rose flower extracts, it has emerged that products prepared from dried rose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19da882d5b30c6251cb0553c4eb6071b
https://doi.org/10.1080/10826076.2021.1930041

In vitro biological activity of Salvia fruticosa Mill. infusion against amyloid β-peptide-induced toxicity and inhibition of GSK-3β, CK-1δ, and BACE-1 enzymes relevant to Alzheimer's disease

Autor: Miyase Gözde Gündüz, L. Ömür Demirezer, Concepción Pérez, Alim Hüseyin Dokumaci, Mükerrem Betül Yerer, Mehmet Yavuz Paksoy, Perihan Gürbüz, Fatih Göger

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Saudi Pharmaceutical Journal, Vol 29, Iss 3, Pp 236-243 (2021)
Saudi Pharmaceutical Journal : SPJ

The authors would like to thank Dr. Ana Martinez (CSIC-CIB) for her kind and valuable support concerning the enzyme assays. Also many thanks to Dr. Ahmet Cumaog ̆lu for processing and arranging the Western blotting figures for the manuscript. MGG wo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18aa0572e2a2ad718908193b436814b
http://hdl.handle.net/10261/266194

Metabolomics Studies on Asteraceae Family Plants to Find Cytotoxic Drug Candidates

Autor: Engin Koçak, Ekrem Murat Gonulalan, Omer Bayazeid, Funda Nuray Yalçin, L. Ömür Demirezer, Emirhan Nemutlu

Publikováno v: Proceedings, Vol 40, Iss 1, p 36 (2019)

Cancer is one of the major causes of death globally, which involves uncontrollable growth and spread of abnormal cells. Cytotoxic plant extracts may act on various cancer cells. In this study cytotoxicity of five cultivated Asteraceae plant extracts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db555d1ebc60b45bbe4c14ff95f0b71e
https://doi.org/10.3390/proceedings2019040036

The discovery of potential anticholinesterase compounds from Achillea millefolium L

Autor: Zühal Güvenalp, Hafize Yuca, L. Ömür Demirezer, Handan G. Sevindik, Kadir Ozden Yerdelen

Publikováno v: Industrial Crops and Products. 76:873-879

Luteolin ( 1 ), apigenin-7- O -β-D-glucoside ( 2 ), luteolin 7- O -β-D-glucoside ( 3 ), 6-OH-luteolin 7- O -β-D-glucoside ( 4 ) were isolated from Achillea millefolium L. These flavonoids and different polarity fractions of methanol extract from a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0ca62b64a00daf270b799e36c6f8daa
https://doi.org/10.1016/j.indcrop.2015.05.088