Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells.

Autor: Huang Y; Department of Physiology, School of Medicine, Jinan University, Guangzhou, China., Mo H; Department of Physiology, School of Medicine, Jinan University, Guangzhou, China., Yang J; Department of Pathology, School of Basic Medicine, Guangzhou Medical University, Guangdong, China., Gao L; Department of Physiology, School of Medicine, Jinan University, Guangzhou, China., Tao T; Department of Physiology, School of Medicine, Jinan University, Guangzhou, China., Shu Q; Department of Physiology, School of Medicine, Jinan University, Guangzhou, China., Guo W; Department of Physiology, School of Medicine, Jinan University, Guangzhou, China., Zhao Y; Department of Physiology, School of Medicine, Jinan University, Guangzhou, China., Lyu J; Department of Physiology, School of Medicine, Jinan University, Guangzhou, China., Wang Q; Biotherapy Center, Cell-gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Guo J; School of Medicine, The Chinese University of Hong Kong, Shenzhen, China., Zhai H; Endoscopy Center, The First Affiliated Hospital of Jinan University, Guangzhou, China., Zhu L; Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, China., Chen H; Biotherapy Center, Cell-gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Xu G; Department of Physiology, School of Medicine, Jinan University, Guangzhou, China.; Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, China.

Publikováno v: ELife [Elife] 2024 Nov 07; Vol. 13. Date of Electronic Publication: 2024 Nov 07.

The release of GLP-1 from gut L cells is inhibited by low extracellular pH.

Autor: Garbutt P; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Cyranka M; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Michl J; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Maejima Y; Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan., Vedovato N; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Shimomura K; Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan., Swietach P; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., de Wet H; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

Publikováno v: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2024 Oct; Vol. 32 (10), pp. 1819-1824. Date of Electronic Publication: 2024 Sep 05.

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Heterologous expression of P9 from Akkermansia muciniphila increases the GLP-1 secretion of intestinal L cells.

Autor: Di W; College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China., Zhang Y; College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China., Zhang X; Department of Food Science, Beijing University of Agriculture, Beijing, China., Han L; College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China., Zhao L; College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.; Food Laboratory of Zhongyuan, Luohe, Henan, 462300, China., Hao Y; Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100093, China.; Food Laboratory of Zhongyuan, Luohe, Henan, 462300, China., Zhai Z; College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China. zhaizy@cau.edu.cn.; Food Laboratory of Zhongyuan, Luohe, Henan, 462300, China. zhaizy@cau.edu.cn.

Publikováno v: World journal of microbiology & biotechnology [World J Microbiol Biotechnol] 2024 May 10; Vol. 40 (7), pp. 199. Date of Electronic Publication: 2024 May 10.

Common food additive carrageenan inhibits proglucagon expression and GLP-1 secretion by human enteroendocrine L-cells

Autor: Sumit Bhattacharyya, Alip Borthakur, Joanne K. Tobacman

Publikováno v: Nutrition & Diabetes, Vol 14, Iss 1, Pp 1-4 (2024)

Abstract Proglucagon mRNA expression and GLP-1 secretion by cultured human L-cells (NCI-H716) were inhibited following exposure to λ-carrageenan, a commonly used additive in processed foods. Carrageenan is composed of sulfated or unsulfated galactos

Externí odkaz: https://doaj.org/article/b79378c588164a67b7a958128d947dca