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Cytokines induce urokinase-dependent adhesion of human myeloid cells. A regulatory role for plasminogen activator inhibitors

Autor: L. Z. Sailor, D A Waltz, Harold A. Chapman

Publikováno v: Journal of Clinical Investigation. 91:1541-1552

Differentiation of monocytic precursors often results in adhesive properties thought to be important in migration. In this study, the influence of cytokines, known to induce macrophage differentiation, on the adhesiveness of the monocytic cell line U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597e3e5d1da766cdbddfea1ff24a2e19
https://doi.org/10.1172/jci116360

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Cigarette smoking induces an elastolytic cysteine proteinase in macrophages distinct from cathepsin L

Autor: R W Mason, P Chen, L. Z. Sailor, Harold A. Chapman, D. Wilcox, John J. Reilly

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 261:L41-L48

Degradation of the interstitium of the lung by elastolytic enzymes is thought to be a critical component of the pathogenesis of emphysema. Alveolar macrophages are increased in numbers in cigarette smokers and contain the elastolytic cysteine protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9978bb4e8393813ab6787e99a3acae2d
https://doi.org/10.1152/ajplung.1991.261.2.l41

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Developmental expression of plasminogen activator inhibitor type 1 by human alveolar macrophages. Possible role in lung injury

Autor: H A Chapman, X L Yang, L Z Sailor, D J Sugarbaker

Publikováno v: The Journal of Immunology. 145:3398-3405

Urokinase activity is regulated by the specific endogenous plasminogen activator inhibitors type 1 (PAI-1) and type 2 (PAI-2). One of these inhibitors, PAI-1, has been directly implicated in connective tissue metabolism by virtue of its ability to bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc77b2d51488408631cc37e23ecefb02
https://doi.org/10.4049/jimmunol.145.10.3398

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Alveolar macrophage urokinase receptors localize enzyme activity to the cell surface

Autor: A. R. Nusrat, Harold A. Chapman, L. Z. Sailor, Paul Bertozzi

Publikováno v: The American journal of physiology. 259(6 Pt 1)

Human alveolar macrophages are known to synthesize urokinase (uPA) and a specific plasminogen activator inhibitor, PAI-2. In this study we have identified a uPA receptor expressed by these cells and defined the influence of PAI-2 on the interaction o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c93e59418c6420f930334c660a41b6
https://pubmed.ncbi.nlm.nih.gov/2175557

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Developmental expression of plasminogen activator inhibitor type 1 by human alveolar macrophages. Possible role in lung injury

Autor: H A, Chapman, X L, Yang, L Z, Sailor, D J, Sugarbaker

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 145(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c989215cb0cee4c33455534b1180d102
https://pubmed.ncbi.nlm.nih.gov/2230126

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Uptake of extracellular enzyme by a novel pathway is a major determinant of cathepsin L levels in human macrophages

Autor: L. Z. Sailor, Harold A. Chapman, John J. Reilly, P Chen, R W Mason

Publikováno v: The Journal of clinical investigation. 86(1)

The phorbol myristate acetate (PMA)-differentiated myelomonocytic cell line, THP-1, and human alveolar macrophages contain the cysteine proteinase cathepsin L. This enzyme is synthesized as a 43-kD proenzyme and processed to the active 25-kD form. Di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3503177d6987a0f8fb19d6dcc581873d
https://pubmed.ncbi.nlm.nih.gov/2365815

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