In vitro and in vivo experimental hepatotoxic models in liver research: applications to the assessment of potential hepatoprotective drugs

Autor: M Kgalalelo Kemelo, L Wojnarová, N Kutinová Canová, H Farghali

Publikováno v: Scopus-Elsevier

This mini-review highlights our and others’ experience about in vitro and in vivo models that are being used to follow up events of liver injuries under various hepatotoxic agents and potential hepatoprotective drugs. Due to limitations of the outc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9033a2e498093a97a73407e9f673735f
https://pubmed.ncbi.nlm.nih.gov/28006924

D-galactosamine/lipopolysaccharide-induced hepatotoxicity downregulates sirtuin 1 in rat liver: Role of sirtuin 1 modulation in hepatoprotection

Autor: M. K. Kemelo, Hassan Farghali, N Kutinová Canová, L Wojnarová

Publikováno v: Scopus-Elsevier
ResearcherID
Europe PubMed Central

D-Galactosamine/Lipopolysaccharide (D-GalN/LPS) is a well known model of hepatotoxicity that closely resembles acute liver failure (ALF) seen clinically. The role of sirtuin 1 in this model has not yet been documented. However, there have been a numb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7500cb3646239b9d09bdb4ea6faae39a
http://www.scopus.com/inward/record.url?eid=2-s2.0-84920008183&partnerID=MN8TOARS

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Noncanonical Wnt5a/JNK Signaling Contributes to the Development of D-Gal/LPS-Induced Acute Liver Failure.

Autor: Ji XF; Department of Hepatology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, 266035, China., Fan YC; Department of Hepatology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.; Institute of Hepatology, Shandong University, Jinan, 250012, China., Sun F; Department of Hepatology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, 266035, China., Wang JW; Department of Hepatology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, 266035, China., Wang K; Department of Hepatology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China. wangdoc2010@163.com.; Institute of Hepatology, Shandong University, Jinan, 250012, China. wangdoc2010@163.com.; Hepatology Institute of Shandong University, Wenhuaxi Road 107#, 250012, Jinan, Shandong, China. wangdoc2010@163.com.

Publikováno v: Inflammation [Inflammation] 2022 Jun; Vol. 45 (3), pp. 1362-1373. Date of Electronic Publication: 2022 Jan 31.