Zobrazeno 1 - 10
of 21
pro vyhledávání: '"L W, Hertel"'
Autor:
W B, Parker, S C, Shaddix, L M, Rose, D S, Shewach, L W, Hertel, J A, Secrist, J A, Montgomery, L L, Bennett
Publikováno v:
Molecular pharmacology. 55(3)
In an effort to understand biochemical features that are important to the selective antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine [Cl-F( upward arrow)-dAdo], we evaluated the biochemical pharmacology of three stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b4d7445517df705c9b947bfadebfc66
https://pubmed.ncbi.nlm.nih.gov/10051535
https://pubmed.ncbi.nlm.nih.gov/10051535
Publikováno v:
Cancer research. 56(19)
The activity of gemcitabine (dFdC), an effective agent against solid tumors, depends on the incorporation of its triphosphate into DNA. In vitro investigations demonstrated that, depending on the sequence of template DNA, polymerases may pause after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16a1b031449bb3bbd098b2dec6f4101b
https://pubmed.ncbi.nlm.nih.gov/8813140
https://pubmed.ncbi.nlm.nih.gov/8813140
Autor:
L. W. Hertel, J. S. Kroin, C. S. Grossman, Gerald B. Grindey, A. F. Dorr, A. M. V. Storniolo, W. Plunkett, V. Gandhi, P. Huang
Publikováno v:
ACS Symposium Series ISBN: 9780841234420
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe7ca1bf8193ffbcbb54450fc1c52255
https://doi.org/10.1021/bk-1996-0639.ch019
https://doi.org/10.1021/bk-1996-0639.ch019
Autor:
S L, Andis, J R, Bewley, G B, Boder, T, Burke, D E, Dudley, L E, Eichelberger, C S, Grossman, G B, Grindey, L W, Hertel, C L, Jordan
Publikováno v:
Seminars in oncology. 22(4 Suppl 11)
A series of over 70 difluoropurine analogs was synthesized by varying the C-2, 6 and 8 substituents about the purine ring system. After initial in vitro and in vivo screening, testing concentrated on the 2,6-diaminopurine analog (dFdAP) and the guano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2afcddb617274380eb5508515bd9fef3
https://pubmed.ncbi.nlm.nih.gov/7481846
https://pubmed.ncbi.nlm.nih.gov/7481846
Autor:
V, Gandhi, S, Mineishi, P, Huang, Y, Yang, S, Chubb, A J, Chapman, B J, Nowak, L W, Hertel, W, Plunkett
Publikováno v:
Seminars in oncology. 22(4 Suppl 11)
The success of gemcitabine (2',2'-difluorodeoxycytidine; dFdC) resulted in new interest in its purine congeners. Based on the structure-activity relationship studies of catabolism and anabolism, 2',2'-difluorodeoxyguanosine (dFdG) emerged as a lead c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::395824e9164f0037b7bd8038b26c44ec
https://pubmed.ncbi.nlm.nih.gov/7481847
https://pubmed.ncbi.nlm.nih.gov/7481847
Autor:
V, Gandhi, S, Mineishi, P, Huang, A J, Chapman, Y, Yang, F, Chen, B, Nowak, S, Chubb, L W, Hertel, W, Plunkett
Publikováno v:
Cancer research. 55(7)
The emerging clinical success of gemcitabine (2',2'-difluorodeoxycytidine) stimulated interest in the synthesis and evaluation of purine congeners. The cytotoxicity, metabolism, and mechanisms of action of the lead candidate, 2',2'-difluorodeoxyguano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::60abdde7dd076f8654f5c471c4b11533
https://pubmed.ncbi.nlm.nih.gov/7533664
https://pubmed.ncbi.nlm.nih.gov/7533664
Publikováno v:
Cancer research. 54(12)
Difluorodeoxycytidine (dFdCyd) is a new antimetabolite with clinical activity in patients with solid tumors but not leukemias. We have studied the metabolism, cytotoxicity, and radiosensitizing properties of dFdCyd in HT-29 human colon carcinoma cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dda5962e6a8c9c9f9891f6e447d5e116
https://pubmed.ncbi.nlm.nih.gov/8205542
https://pubmed.ncbi.nlm.nih.gov/8205542
Publikováno v:
Cancer research. 53(19)
Gemcitabine [2',2'-difluorodeoxycytidine (dFdCyd)], a potent antitumor agent, inhibits DNA synthesis and is incorporated internally into DNA. The effect of a template-incorporated dFdCyd molecule (dFdCyd-) on DNA polymerase function was examined. Two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b7da9d6afc166bc3f22d20f74c0aad41
https://pubmed.ncbi.nlm.nih.gov/8402631
https://pubmed.ncbi.nlm.nih.gov/8402631
Publikováno v:
Oncology research. 5(2)
2',2'-Difluorodeoxycytidine (Gemcitabine, dFdCyd) is a cytotoxic agent which is active toward a variety of tumor cells. It has been shown that there are multiple intracellular sites of action which include ribonucleotide reductase and DNA polymerase.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::94f986ea0526c092e95b0ec35a308197
https://pubmed.ncbi.nlm.nih.gov/8364254
https://pubmed.ncbi.nlm.nih.gov/8364254
Autor:
R M, Schultz, R L, Merriman, J E, Toth, J E, Zimmermann, L W, Hertel, S L, Andis, D E, Dudley, P G, Rutherford, L R, Tanzer, G B, Grindey
Publikováno v:
Oncology research. 5(6-7)
Human pancreatic carcinoma xenograft models were developed from established MIA PaCa-2 and PANC-1 cell lines (ATCC, Rockville, MD). Tumors were maintained by serial trocar implantation in CD1 nu/nu mice, and attempts were made to test all drugs under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::72ceb2e3fe11a65b4f7874300b0e01df
https://pubmed.ncbi.nlm.nih.gov/8123942
https://pubmed.ncbi.nlm.nih.gov/8123942