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Spontaneous apoptosis in lymphocytes from patients with Wiskott-Aldrich syndrome: correlation of accelerated cell death and attenuated bcl-2 expression

Autor: S L, Rawlings, G M, Crooks, D, Bockstoce, L W, Barsky, R, Parkman, K I, Weinberg

Publikováno v: Blood. 94(11)

Wiskott-Aldrich syndrome (WAS) is an X-linked recessive disorder characterized by thrombocytopenia, eczema, and a progressive deterioration of immune function. WAS is caused by mutations in an intracellular protein, WASP, that is involved in signal t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f8c0d2bec28b719e2a59c057dc0d6ad7
https://pubmed.ncbi.nlm.nih.gov/10572103

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In vitro identification of single CD34+CD38- cells with both lymphoid and myeloid potential

Autor: Q L, Hao, E M, Smogorzewska, L W, Barsky, G M, Crooks

Publikováno v: Blood. 91(11)

Human hematopoietic stem cells are pluripotent, ie, capable of producing both lymphoid and myeloid progeny, and are therefore used for transplantation and gene therapy. An in vitro culture system was developed to study the multi-lineage developmental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::943aeb0c5f278ac1433218cf6497b8f0
https://pubmed.ncbi.nlm.nih.gov/9596660

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