Výsledky vyhledávání - "L V, Favreau"

Mechanism-based inactivation of CYP2D6 by 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine

Autor: J R, Palamanda, C N, Casciano, L A, Norton, R P, Clement, L V, Favreau, C, Lin, A A, Nomeir

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(6)

SCH 66712 [5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine] caused a time- and NADPH-dependent loss of CYP2D6 activity. The inactivation of human liver (HL) microsomal dextromethorphan O-demethylase activity, a prototype ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ac2f0d04fc0485be3ad4394d62a415a0
https://pubmed.ncbi.nlm.nih.gov/11353755

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Inhibition of CYP3A4 in a rapid microtiter plate assay using recombinant enzyme and in human liver microsomes using conventional substrates

Autor: A A, Nomeir, C, Ruegg, M, Shoemaker, L V, Favreau, J R, Palamanda, P, Silber, C C, Lin

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(5)

Cytochrome P450 inhibition studies are performed in the pharmaceutical industry in the discovery stage to screen candidates that may have the potential for clinical drug-drug interactions. A 96-well microtiter plate assay using recombinant cytochrome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9033c517bafc5b2fe975acc299619303
https://pubmed.ncbi.nlm.nih.gov/11302943

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Improved reliability of the rapid microtiter plate assay using recombinant enzyme in predicting CYP2D6 inhibition in human liver microsomes

Autor: L V, Favreau, J R, Palamanda, C C, Lin, A A, Nomeir

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 27(4)

A higher throughput method of screening for the inhibition of recombinant CYP2D6 using a microtiter plate (MTP) assay was evaluated using 62 new chemical entities and compared to data from the dextromethorphan O-demethylase assay in human liver micro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bcc01bede7dbb874d2c75308388ef7a5
https://pubmed.ncbi.nlm.nih.gov/10101136

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The rat quinone reductase antioxidant response element. Identification of the nucleotide sequence required for basal and inducible activity and detection of antioxidant response element-binding proteins in hepatoma and non-hepatoma cell lines

Autor: L V, Favreau, C B, Pickett

Publikováno v: The Journal of biological chemistry. 270(41)

The antioxidant response element (ARE) found in the 5'-flanking region of the rat quinone reductase gene has been further characterized by mutational and deletion analysis. The results indicate that the 31-base pair ARE, which contains a 13-base pair

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eb3a902843a6ec16a9708719ee7bac24
https://pubmed.ncbi.nlm.nih.gov/7592662

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Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Characterization of a DNA-protein interaction at the antioxidant responsive element and induction by 12-O-tetradecanoylphorbol 13-acetate

Autor: L V, Favreau, C B, Pickett

Publikováno v: The Journal of biological chemistry. 268(26)

We have previously identified a novel xenobiotic responsive element, which has been termed the antioxidant responsive element (ARE), in the 5'-flanking region of the rat quinone reductase gene (Favreau, L. V., and Pickett, C. B. (1991) J. Biol. Chem.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2645f590ea5303f3095af73304c3524e
https://pubmed.ncbi.nlm.nih.gov/8396148

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Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Identification of regulatory elements controlling basal level expression and inducible expression by planar aromatic compounds and phenolic antioxidants

Autor: L V, Favreau, C B, Pickett

Publikováno v: The Journal of biological chemistry. 266(7)

We have identified two regions in the 5'-flanking sequence of the rat quinone reductase gene that contain xenobiotic responsive elements. The DNA sequence of the first region spans nucleotides -393 to -352 of the 5'-flanking region and shares sequenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bdef4d8e0753ae200e75b79200c62d7c
https://pubmed.ncbi.nlm.nih.gov/1900296

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Purification and properties of human platelet heparitinase

Autor: G M Oosta, L V Favreau, David L. Beeler, Robert D. Rosenberg

Publikováno v: Journal of Biological Chemistry. 257:11249-11255

An endoglycosidase which cleaves heparin and heparan sulfate was isolated from outdated human platelets by freeze-thaw solubilization, heparin-Sepharose chromatography, DEAE-cellulose chromatography, hydroxylapatite chromatography, octyl-agarose chro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::331107b431c8598e641d515e8eb9bdf2
https://doi.org/10.1016/s0021-9258(18)33749-9

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Inhibition of vascular smooth muscle cell growth by endothelial cell-derived heparin. Possible role of a platelet endoglycosidase

Autor: L V Favreau, Morris J. Karnovsky, John J. Castellot, Robert D. Rosenberg

Publikováno v: Journal of Biological Chemistry. 257:11256-11260

Bovine aortic endothelial cells release a heparin-like substance in the presence of 0.4% fetal calf serum. This substance inhibited the growth of smooth muscle cells in vitro by about 70%. Substitution of platelet-poor plasma for serum resulted in mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aad363a1e06c5c2468758ead01a70ab4
https://doi.org/10.1016/s0021-9258(18)33750-5

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