Zobrazeno 1 - 9 of 9 pro vyhledávání: '"L T da Costa"'
1
Converting cancer genes into killer genes
Autor: Kenneth W. Kinzler, L T Da Costa, Jin Jen, Timothy A. Chan, Tong-Chuan He, Bert Vogelstein
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 93(9)
Over the past decade, it has become clear that tumorigenesis is driven by alterations in genes that control cell growth or cell death. Theoretically, the proteins encoded by these genes provide excellent targets for new therapeutic agents. Here, we d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3fad8f3b5568ae41943d92dc17af3a4
https://pubmed.ncbi.nlm.nih.gov/8633039
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2
Homozygous deletion map at 18q21.1 in pancreatic cancer
Autor: S A, Hahn, A T, Hoque, C A, Moskaluk, L T, da Costa, M, Schutte, E, Rozenblum, A B, Seymour, C L, Weinstein, C J, Yeo, R H, Hruban, S E, Kern
Publikováno v: Cancer research. 56(3)
Absolute genetic differences between neoplastic and nonneoplastic cells can be discerned at sites of homozygous deletions. These deletions are of critical interest because they might be useful in the identification of defective biochemical pathways i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5ea254300dc688dbe1171dbac786bcbd
https://pubmed.ncbi.nlm.nih.gov/8564959
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3
Identification by representational difference analysis of a homozygous deletion in pancreatic carcinoma that lies within the BRCA2 region
Autor: Mieke Schutte, J.M. Trent, Ester Rozenblum, Hoque At, L T da Costa, M. Bittner, C. L. Weinstein, Christopher A. Moskaluk, Stephan A. Hahn, Paul S. Meltzer
Homozygous deletions have been central to the discovery of several tumor-suppressor genes, but their finding has often been either serendipitous or the result of a directed search. A recently described technique [Lisitsyn, N., Lisitsyn, N. & Wigler,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64224a3af0aa0e600f884283739ce91
https://europepmc.org/articles/PMC41619/
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4
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
Autor: Charles J. Yeo, Ralph H. Hruban, Scott E. Kern, A. B. Seymour, Mieke Schutte, Stephan A. Hahn, Carlos Caldas, Mark Redston, L T da Costa, C. L. Weinstein
Publikováno v: Nature genetics. 8(1)
The MTS1 gene on chromosome 9p21 encodes the p16 inhibitor of cyclinD/Cdk-4 complexes, and is deleted or mutated in a variety of tumour types. We found allelic deletions of 9p21-p22 in 85% of pancreatic adenocarcinomas. Analysis of MTS1 in pancreatic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7b69496b09ace69471b158b935bb2f
https://pubmed.ncbi.nlm.nih.gov/7726912
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8
[Poliomyelitis]
Autor: H G, Schatzmayr, L T, da Costa
Publikováno v: Boletim do Instituto de Puericultura e Pediatria Martagao Gesteira. 23(1)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2ecdd98adf1fcfdfe6e0b17cddc98912
https://pubmed.ncbi.nlm.nih.gov/4287725
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