Zobrazeno 1 - 10
of 290
pro vyhledávání: '"L Sinn"'
Autor:
Nur P. Damayanti, M. Reza Saadatzadeh, Erika Dobrota, Josue D. Ordaz, Barbara J. Bailey, Pankita H. Pandya, Khadijeh Bijangi-Vishehsaraei, Harlan E. Shannon, Anthony Alfonso, Kathy Coy, Melissa Trowbridge, Anthony L. Sinn, Zhong-Yin Zhang, Rosa I. Gallagher, Julia Wulfkuhle, Emanuel Petricoin, Angela M. Richardson, Mark S. Marshall, Alex Lion, Michael J. Ferguson, Karl E. Balsara, Karen E. Pollok
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Pleomorphic xanthoastrocytoma (PXA) is a rare subset of primary pediatric glioma with 70% 5-year disease free survival. However, up to 20% of cases present with local recurrence and malignant transformation into more aggressive type anaplast
Externí odkaz:
https://doaj.org/article/e5789262b3ec42119349962b8c13096b
Autor:
Ashley L. Cooney, Christian M. Brommel, Soumba Traore, Gregory A. Newby, David R. Liu, Paul B. McCray, Patrick L. Sinn
Publikováno v:
Frontiers in Genome Editing, Vol 5 (2023)
Considerable effort has been devoted to developing adeno-associated virus (AAV)-based vectors for gene therapy in cystic fibrosis (CF). As a result of directed evolution and capsid shuffling technology, AAV capsids are available with widespread tropi
Externí odkaz:
https://doaj.org/article/9022961518b6498c9920e9f7bf41f264
Autor:
Lei Lei, Soumba Traore, Guillermo S. Romano Ibarra, Philip H. Karp, Tayyab Rehman, David K. Meyerholz, Joseph Zabner, David A. Stoltz, Patrick L. Sinn, Michael J. Welsh, Paul B. McCray Jr., Ian M. Thornell
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
The volume and composition of a thin layer of liquid covering the airway surface defend the lung from inhaled pathogens and debris. Airway epithelia secrete Cl– into the airway surface liquid through cystic fibrosis transmembrane conductance regula
Externí odkaz:
https://doaj.org/article/2cd2777105f44a3382766c3e36dc6f28
Autor:
Lorellin A. Durnell, Camilla E. Hippee, Roberto Cattaneo, Jennifer A. Bartlett, Brajesh K. Singh, Patrick L. Sinn
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT Amplification of measles virus (MeV) in human airway epithelia may contribute to its extremely high contagious nature. We use well-differentiated primary cultures of human airway epithelial cells (HAE) to model ex vivo how MeV spreads in hum
Externí odkaz:
https://doaj.org/article/4b662682a9b7474390e2f8c7b025bd94
Autor:
Ashley L. Cooney, Andrew L. Thurman, Paul B. McCray, Jr., Alejandro A. Pezzulo, Patrick L. Sinn
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 293-301 (2021)
Life-long expression of a gene therapy agent likely requires targeting stem cells. Here we ask the question: does viral vector transduction or ectopic expression of a therapeutic transgene preclude airway stem cell function? We used a lentiviral vect
Externí odkaz:
https://doaj.org/article/81f681dea87b44bdb14b49d961933705
Autor:
Laura I. Marquez Loza, Ashley L. Cooney, Qian Dong, Christoph O. Randak, Stefano Rivella, Patrick L. Sinn, Paul B. McCray, Jr.
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 94-106 (2021)
Despite significant advances in cystic fibrosis (CF) treatments, a one-time treatment for this life-shortening disease remains elusive. Stable complementation of the disease-causing mutation with a normal copy of the CF transmembrane conductance regu
Externí odkaz:
https://doaj.org/article/d0519b4aa458485db73ff7f204fe6471
Autor:
Ashley L Cooney, Patrick L Sinn
Publikováno v:
BioTechniques, Vol 68, Iss 5, Pp 235-239 (2020)
Gene therapy for airway diseases requires efficient delivery of nucleic acids to the airways. In small animal models, gene delivery reagents are commonly delivered as a bolus dose. However, large animal models are often more relevant for the transiti
Externí odkaz:
https://doaj.org/article/fd6d866fef0e478eaa364a67cf87af9a
Publikováno v:
Frontiers in Genome Editing, Vol 3 (2022)
Pulmonary surfactant is critically important to prevent atelectasis by lowering the surface tension of the alveolar lining liquid. While respiratory distress syndrome (RDS) is common in premature infants, severe RDS in term and late preterm infants s
Externí odkaz:
https://doaj.org/article/fcdff47321004f249cd2be27366c32cb
Measles virus exits human airway epithelia within dislodged metabolically active infectious centers.
Autor:
Camilla E Hippee, Brajesh K Singh, Andrew L Thurman, Ashley L Cooney, Alejandro A Pezzulo, Roberto Cattaneo, Patrick L Sinn
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009458 (2021)
Measles virus (MeV) is the most contagious human virus. Unlike most respiratory viruses, MeV does not directly infect epithelial cells upon entry in a new host. MeV traverses the epithelium within immune cells that carry it to lymphatic organs where
Externí odkaz:
https://doaj.org/article/14e02861722249fbadcfe8765f2c24eb
Autor:
Chandrali S. Bhattacharya, Andrea R. Masters, Christine Bach, Anthony L. Sinn, Melissa A. Trowbridge, Robert E. Stratford
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 48:171-187
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c97ff52ce0a76da6765004c3132de41b
https://doi.org/10.1007/s13318-023-00817-9
https://doi.org/10.1007/s13318-023-00817-9