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PREVENTION OF PRIMARY NONFUNCTION OF CANINE ISLET AUTOGRAFTS BY TREATMENT WITH PRAVASTATIN1

Autor: Yoko Mullen, M Ochiai, Yoshimasa Sakamoto, L Shevlin, Tetsu Nagai, Craig Smith, Seiji Arita

Publikováno v: Transplantation. 73:7-12

Background. Nonspecific inflammation is the primary cause of early islet graft loss. We have shown in mice that pravastatin, a 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitor, prevents primary nonfunction of islet isografts by reducing infla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f25f84db8bbdca97507f4611bd22b152
https://doi.org/10.1097/00007890-200201150-00003

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Clinical islet transplantation experience of the University of California Islet Transplant Consortium

Autor: Watt Pc, Yoko Mullen, Robert Kleinman, Edward Passaro, Satoshi Une, Seiji Arita, Peter G. Stock, Pierre Y. Benhamou, Takashi Kenmochi, Yoshi Wantanabe, L Shevlin, Yasu Nomura, F. Charles Brunicardi, Thomas J. Rosenthal, S. Ohtsuka, A. Atiya, Ronald W. Busuttil, Masaaki Miyamato

Publikováno v: Surgery. 118:967-972

Background. The University of California Islet Transplant Consortium was formed to evaluate the feasibility of performing clinical islet transplantation at different transplant centers by using a single centralized islet isolation laboratory. Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f37147cf60e32ca3cf08a03c5d1dc45
https://doi.org/10.1016/s0039-6060(05)80101-1

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Essential Fatty Acid Deficiency Prevents Autoimmune Diabetes in Nonobese Diabetic Mice Through a Positive Impact on Antigen-Presenting Cells and Th2 Lymphocytes

Autor: Michael J. Clare-Salzler, Corinne Benhamou, Yoko Mullen, Pierre Y. Benhamou, Amarin Sangkharat, L Shevlin, Vay Liang W. Go

Publikováno v: Pancreas. 11:26-37

Protective effects of essential fatty acid deficiency (EFAD) on autoimmunity were shown in rodents. Our goal was to investigate the mechanisms of EFAD effects on autoimmune diabetes in nonobese diabetic (NOD) mice. Weanling female mice were randomize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4183b6d274c32bf0506d1e737f964859
https://doi.org/10.1097/00006676-199507000-00003

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Prevention of primary islet isograft nonfunction in mice with pravastatin

Autor: S, Arita, S, Une, S, Ohtsuka, A, Atiya, A, Kasraie, L, Shevlin, Y, Mullen

Publikováno v: Transplantation. 65(11)

Nonspecific inflammatory damage in the early stages of transplantation is the major cause of primary islet graft nonfunction. Using murine isografts, we attempted to prevent this islet graft damage by treating recipients with pravastatin (Pravacol),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b6674493462fac969042028f0f7766ef
https://pubmed.ncbi.nlm.nih.gov/9645797

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