Zobrazeno 1 - 10 of 632 pro vyhledávání: '"L Schweitzer"'
1
Akademický článek
Translation of the 27-gene immuno-oncology test (IO score) to predict outcomes in immune checkpoint inhibitor treated metastatic urothelial cancer patients
Autor: Robert S. Seitz, Michael E. Hurwitz, Tyler J. Nielsen, Daniel B. Bailey, Matthew G. Varga, Brian Z. Ring, Carrie F. Metts, Brock L. Schweitzer, Kimberly McGregor, Douglas T. Ross
Publikováno v: Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-11 (2022)
Abstract Background The IO Score is a 27-gene immuno-oncology (IO) classifier that has previously predicted benefit to immune checkpoint inhibitor (ICI) therapy in triple negative breast cancer (TNBC) and non-small cell lung cancer (NSCLC). It genera
Externí odkaz: https://doaj.org/article/559b3f8416ed47f4ba8dbc1a517b7989
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2
Akademický článek
Association of a novel 27-gene immuno-oncology assay with efficacy of immune checkpoint inhibitors in advanced non-small cell lung cancer
Autor: Harsha Ranganath, Amit L. Jain, Justin R. Smith, Julie Ryder, Amina Chaudry, Emily Miller, Felicia Hare, Poojitha Valasareddy, Robert S. Seitz, David R. Hout, Matthew G. Varga, Brock L. Schweitzer, Tyler J. Nielsen, Janice Mullins, Douglas T. Ross, David R. Gandara, Gregory A. Vidal
Publikováno v: BMC Cancer, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background Immune checkpoint inhibitor (ICI) therapies represent a major advance in treating a variety of advanced-stage malignancies. Nevertheless, only a subset of patients benefit, even when selected based on approved biomarkers such as P
Externí odkaz: https://doaj.org/article/ca410bdf72ce41f5b615b14aab591ed1
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4
Akademický článek
Characterization of the tumor immune-microenvironment of adenocarcinoma of lung with a metastatic lesion in the pancreas treated successfully with first-line, single-agent pembrolizumab
Autor: David L. Saltman, Tyler J. Nielsen, Davide Salina, David R. Hout, Frank B. McMahon, Boris R. Valev, Michael Huk, Pranil K. Chandra, Jeremy Spille, Robert S. Seitz, Brock L. Schweitzer
Publikováno v: Therapeutic Advances in Medical Oncology, Vol 13 (2021)
Single-agent immune checkpoint inhibitor therapy in advanced non-small cell lung cancer can significantly prolong progression-free and overall survival when compared with cytotoxic chemotherapy. Here, we report a case of newly diagnosed adenocarcinom
Externí odkaz: https://doaj.org/article/7b2d91b2251644438a237f9b577cb0d2
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5
Akademický článek
A novel immuno-oncology algorithm measuring tumor microenvironment to predict response to immunotherapies
Autor: Tyler J. Nielsen, Brian Z. Ring, Robert S. Seitz, David R. Hout, Brock L. Schweitzer
Publikováno v: Heliyon, Vol 7, Iss 3, Pp e06438- (2021)
Immune checkpoint inhibitor (ICI) therapies can improve clinical outcomes for patients with solid tumors, but relatively few patients respond. Because ICI therapies support an adaptive immune response, patients with an active tumor microenvironment (
Externí odkaz: https://doaj.org/article/58ad701311c34bcc966073d484c3d0d5
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6
Akademický článek
Identification of triple-negative breast cancer cell lines classified under the same molecular subtype using different molecular characterization techniques: Implications for translational research.
Autor: Jose Rodrigo Espinosa Fernandez, Bedrich L Eckhardt, Jangsoon Lee, Bora Lim, Troy Pearson, Rob S Seitz, David R Hout, Brock L Schweitzer, Tyler J Nielsen, O Rayne Lawrence, Ying Wang, Arvind Rao, Naoto T Ueno
Publikováno v: PLoS ONE, Vol 15, Iss 4, p e0231953 (2020)
The original algorithm that classified triple-negative breast cancer (TNBC) into six subtypes has recently been revised. The revised algorithm (TNBCtype-IM) classifies TNBC into five subtypes and a modifier based on immunological (IM) signatures. The
Externí odkaz: https://doaj.org/article/5e4d94c8b7bd4f518fc97cd1ff769a6f
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7
Akademický článek
Comparison of triple-negative breast cancer molecular subtyping using RNA from matched fresh-frozen versus formalin-fixed paraffin-embedded tissue
Autor: Bojana Jovanović, Quanhu Sheng, Robert S. Seitz, Kasey D. Lawrence, Stephan W. Morris, Lance R. Thomas, David R. Hout, Brock L. Schweitzer, Yan Guo, Jennifer A. Pietenpol, Brian D. Lehmann
Publikováno v: BMC Cancer, Vol 17, Iss 1, Pp 1-14 (2017)
Abstract Background Triple negative breast cancer (TNBC) is a heterogeneous disease that lacks unifying molecular alterations that can guide therapy decisions. We previously identified distinct molecular subtypes of TNBC (TNBCtype) using gene express
Externí odkaz: https://doaj.org/article/0dd8174f05f648f7b930cfdb70942ede
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