Zobrazeno 1 - 5
of 5
pro vyhledávání: '"L S Ulsh"'
Publikováno v:
Molecular and Cellular Biology. 5:1449-1455
The v-rasH oncogene of Harvey murine sarcoma virus encodes a 21,000-dalton p21 protein which has been expressed at a high level as a fusion protein in Escherichia coli. We have purified the p21 to over 90% in purity without the use of any detergent o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33402c9980e4a20e83ddf4eaa0a14742
https://doi.org/10.1128/mcb.5.6.1449
https://doi.org/10.1128/mcb.5.6.1449
Publikováno v:
Molecular and Cellular Biology. 4:1647-1652
The EJ bladder carcinoma oncogene is activated by a point mutation in the c-rasH proto-oncogene at the 12th amino acid codon. In an attempt to understand the mechanism of oncogenic activation, a comparative study was undertaken to examine the metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6dd2e777bb374cda88848720e9c03d
https://doi.org/10.1128/mcb.4.8.1647
https://doi.org/10.1128/mcb.4.8.1647
The p21 proteins of ras oncogenes are synthesized as precursors in the cytosol. After processing, which involves acylation, the products are associated with the plasma membrane in eucaryotic cells. The p21 overproduced in Escherichia coli, however, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81396d060b51f815c8bec978dba2e610
https://europepmc.org/articles/PMC252618/
https://europepmc.org/articles/PMC252618/
Publikováno v:
Gene amplification and analysis. 4
Cancer is a malfunction of cellular growth control. The discovery of oncogenes, first in transforming retroviruses, and later in human and animal tumors, may have uncovered the key to understanding one of the most elusive subjects of basic cell biolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::07eba33728f9e20f68469c7e81d04e27
https://pubmed.ncbi.nlm.nih.gov/3333361
https://pubmed.ncbi.nlm.nih.gov/3333361
Publikováno v:
Oncogene research. 3(3)
Novel p21 phosphorylation was found in cells expressing high levels of this product of c-H- and c-K-ras genes. Phorbol 12,13-dibutyrate, a protein kinase C (PKC) activator, and permeable c-AMP derivatives, which activate protein kinase A (PKA), stimu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b78c59f4b1fd1e694dc7c4a1488eaf5f
https://pubmed.ncbi.nlm.nih.gov/2849744
https://pubmed.ncbi.nlm.nih.gov/2849744